1. Sedation. Korean scholars Ha [1] in the radioligand binding assay, using rat cerebral cortex membranes to test the effect of five compounds isolated from Cyperus rotundus rhizome ethyl acetate on γ - aminobutyric acid A receptor (GABAA ), benzo benzodiazepine receptor. Among these 5 compounds, only the different curcumol (a newly discovered the sesquiterpene compounds) can inhibit the combination of [3H] Ro15-1788 and enhance the combination of [3H] clonazepam and GABA. The results show that the different curcumol can be benzodiazepine receptor agonists, by enhancing the endogenous receptor ligand combination to allosteric regulate GABA neurotransmission.

2. Protective effect on the gastric mucosal. Zhu [2] modeling with ethanol-induced rat gastric ulcer, firstly the Cyperus rotundus rhizome decoction (1.25, 2.5, 4.0g of the original drug / kg) to rat oral. The result shows that the decoction has a protective effect on the ulcer.Followed by purification of Cyperus rotundus rhizome decoction on rats after subcutaneous injection (0.3 0.6g/kg) is equally effective. The study find that gastric motility speed is the main reason for ulcers, Cyperus rotundus rhizome decoction could delay gastric emptying time to reduce the incidence of ulcers.

3. To reduce blood lipid. Nagulendran, etc. [3]. The divid rats into young mice group and the comparison group, the old mice group and the comparison group, and give them Cyperus ethanol extract 30 days respectively. The results show that the growth of glucose, total cholesterol, triglycerides, LDL and VLDL in serum of old mice with aging significantly reduced. This revealed that Cyperus can prevent cardiovascular diseases by aging. Christina, etc. [4] giving mice who is in ethanol-induced liver injury Cyperus rotundus alcohol extract 28 days later, find that mice’s triacylglycerol in blood decreased significantly, so does to the treatment of hypertriglyceridemia.

4. Lower blood sugar. Nishikant etc [5] to test the effect of Cyperus rotundus rhizome extract treatment on diabetes with alloxan-induced hyperglycemia mice. After mice taking continuous oral administration of 500mg 7 days, its blood glucose significantly reduced. This is due to the strong scavenging capacity, antioxidant activity in vitro 1, 1diphenyl a bitter base hydrazine (DPPH), and has led to the antihyperglycemic activity. Oxygen free radicals and alloxan induced diabetic activity, antioxidants are very effective for diabetes. Yazdanparast etc. in vitro studies [6] also find the inhibition of Cyperus ethanol extract on DPPH and superoxide in rat liver homogenate, the scavenging effect on free radical, and the strong antioxidant effect.

5. Anti-bacterial and anti-inflammatory effect. Uddin et al. [7] find that the methanol extract of Cyperus rotundus rhizome significantly against to dysentery which caused by the rat oral castor oil. In separated parts, petroleum ether and residual methanol existing this kind of activity, and the later one existing even stronger activity than the control group. The ethyl acetate part wih no activity of anti-dysentery. Yu et al [8] find that Cyperus rotundus extract with concentration 4mg/ml can effectively inhibit the adhesion of Streptococcus in painted saliva hydroxyapatite, indicating that the Cyperus rotundus extract have a preventive effect on dental caries caused by Streptococcus variant. Duarte et al [9] find that the Cyperus water extract has peritonitis treatment for rosary nature peritonitis, while no effect for ethanol extract. The antibacterial of properties of cyperus rotundus rhizome extract with five kinds of comparison bacteria to assess. The total flavonoids and extracted with ethyl acetate portion have significant inhibition to Salmonella enteritidis, Staphylococcus aureus and Enterococcus faecalis [10].

6. Anti-mutagenic activity: determination of the Salmonella typhimurium, study the anti-mutagenic activity of Cyperus water extract, the total oligomeric flavonoid extract, ethyl acetate and methanol extracts. The results show that all of the extracts on aflatoxin Bl (AFBI) and azides of sodium (sodium azide) have strong anti-mutagenic activity, 50% inhibitory concentration values (IC 50) are 15, 14 and 20g/ml [11].

1. Migraine, headache

2. Scalp swelling and pain, pain at both temples, vertigo and dizziness

3. Diseases due to disorder of qi: distention and fullness of heart and abdomen, dysphagia of chest and diaphragm, belching, acid regurgitation, vomiting phlegm from the stomach, hangover, and loss of appetite

4. Depression and obstruction of chest and diaphragm due to rising of wind-qi and retention of phlegm and fluid

5. Epistaxis

6. Hematemesis

7. Hematuria

8. Anti0aboryion measuccessful gestation

9. Leukorrhea due to deficiency cold of the lower abdomen

化学成分：

[1] Lin Xiaoshan, Wu Huiqin, Huang Fang, et al. Cyperus rotundus volatile oil extraction and GC/MS analysis. Journal of mass spectrometry, 2006,27 ( 1): 40

[2] State Administration of traditional Chinese materia medica editorial board. " " Chinese materia medica. Shanghai: Shanghai science and Technology Press, 1999,24:561 ( total 7702).

药理作用：

[1]Ha JH, Lee KY, Choi HC, et al. Modulation of Radioligand Binging to the GABAA-benzodiazepine Receptor Complex by a New Component from Cyprus Rotundus[J].Biol Pharm Bull, 2002,25(1):128-130

[2]Zhu M,Luk HH,Fung HS,et al.Cytoprotective Effects of Cyperus rotundus against Ethanol Induced Gastric Ulceration in Rats[J].Phytotherapy Research,1997,11:392-394

[3]Nagulendran KR, Mahesh R, Hazeena BV. Preventive role of cyperus rotundus rhizomes extract on age associated changes in glucose and lipids [J].Pharmacologyonline,2007,2:318-325

[4]Christina AJM,Pillai PG,Chidambaranthan N,et al. Modulating effect of Cyperus rotundus Linn.on ethanol induced damage[EB/OL].http://www.cabi.org,2006-04-01/2009-04-08

[5]Nishikant AR, Naresh JG. Antidiabetic activity of hydroethanol extract of Cyperus rotundus in alloxan induced diabetes in rats [J].Fitoterapia,2006,77:585-588

[6]YazdanParast R,Ardestani A.In vitro antioxidant and free ranical scavenging activity of Cyperus rotundus[J].Medfood,2007,10(4):667-674

[7]Uddin SJ,Mondal K, ShilPi JA,et al. Antidiarrhoeal activity of Cyperus rotudens[J].Fitoterapia,2006,77:134-136

[8]Yu HH,Lee DH,Seo SJ,et al.Anticariogenic properties of the extract of Cyperus rotundus[J].Am J Chin Med,2007,35(3):497-505

[9]Duarte MC, Fiqueira GM, Sartoratto A,et al.Anti-Candida activity of Brazillian medicinal plants [J]. Ethnopharnacol, 2005, 97(2):305-311

[10]Soumaya K, Mohamed BS, llef L,et al. In vitro evaluation of antibacterial, antioxidant, cytotoxic and apoptotic activities of the tubers infusion and extracts of Cyperus rotuduns[J].Bioresource Technology,2008,99:9004-9008

[11]Soumaya K,Ribai B,Ines B,et al.Investigation of extracts from(Tunisian)Cyperus rotundus as antimutagens and radical scavengers[J].Environmental Toxicology and Pharmaclogy,2005,20:478-484

临床试验：

[1] Song Guohua wood Decoction and washing treatment flat wart 50 example. Shaanxi doctor of traditional Chinese medicine, 1986; 7 ( 9): 412

[2] Zhong Desen vinegar to wart solution in the treatment of verruca vulgaris in 50 cases. Chinese Journal of Dermatology, 1993; 7 ( 4): 252

[3] Shen Peng flat verruca tincture in Treating 45 cases of verruca plana. Chinese Journal of integrated traditional and Western medicine, 1993; 13 ( 7): 416

[4] Deng Fenxia, Zhang Huiju. The treatment of flat wart prescription. Chinese herbal medicine, 1993; 16 ( 4): 41

[5] Liu Yaochi washing therapy a clinical observation of 50 cases of verruca vulgaris. Hebei doctor of traditional Chinese medicine, 1985; ( 6): 15

[6] Wei Wenyang. Treatment of 49 cases of unexplained head bulging. Hubei Journal of traditional Chinese medicine, 1992; 14 ( 4): 46

毒理学：

[1]Singh N, et al. Indian J MedRes, 1970,58(1):103

[2] Liu Guoqing, et al. Journal of China Medicine University, 1989,20 ( 1): 48

[3]Wu J Y P,et al .Atn JPharm,1952,124:48