[English Name] | False-yellowflower Milkwort Root | |
[Chinese Name] | 黄花倒水莲 | |
[Pinying Name] | Huanghuadaoshuilian | |
[Latin Name] | Polygalae Fallacis Radix | |
[Genera] | Polygalaceae | |
[Efficacy] | buyao | |
[Pictures] | Plant picture | Drug picture |
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[Alias] | ||
[Source] | ||
[Plant morphology] | ||
[Distribution] | ||
[Gathering and processing] | ||
[Characteristics] | ||
[Ecology] | It grows in valley、dankness beside water at the altitude between 360 to 1650 metres. | |
[Chemical composition] | This plant contains palmitic acid, 1,3-dihydroxy-2- methyl ketone, 2、4 ethyl- stigmast -7,(E)-22- diene -3-ol, p-hydroxybenzaldehyde, 1,3-dihydroxyacetone, 1,3-dihydroxy-2-methoxy ketone, 1- methoxy-2,3-methylenedioxy ketone、1,7- dihydroxy -2,3- methylenedioxy ketone、p-hydroxybenzoic acid, methyl protocatechuate[1]. | |
[Pharmacological activities] |
1. Promoting blood circulation: Polygala Fallax Hemsl(PFH) administrated by gavage of 3g/kg can significantly reduce the femoral vein injection of l0% dextran of high molecular mass 5ml/kg due to acute blood stagnation model rats in 80-20s-1 between different shear rate whole blood viscosity and restore specific viscosity, plasma viscosity must reduce, by inhibiting erythrocyte aggregation, improving erythrocyte deformability, thus improving blood stasis state. PFH could significantly dilate the micro-artery and micro-vein, increase the opening number of capillaries in mice, suggesting that the PFH there is obvious improvement of microcirculation [1]. Polygala Total Saponin (PTS)can obviouly prolong the rabbit plasma recalcification time in vitro, significantly extend the thrombin-induced fiber protein clotting time and partial thromboplastin time,and in vivo administration can significantly prolong the clotting time, no significant effect on prothrombin time.PTS administrated by gavage of 50mg/kg significantly inhibit the carrageenan-induced mice in vivo thrombosis model thrombus length, but also has significant anti-inflammatory effects [2].. 2. Lipid Modulation: Polygala Fallax Hemsl oral solution (PAD) in certain doses can reduce the normal animal serum total cholesterol (TC),triglyceride (TG) and low-density lipoprotein cholesterol (LDL-C),improve high-density lipoprotein cholesterol (HDL-C). PAD can reduce primary hyperlipidemia in the TC, TG, apolipoprotein B (ApoB), lipoprotein (a), LDL-C, atherosclerosis index (TC-HDL-C/HDL-C),and increase HDL-C, apolipoprotein A1 (ApoAl) and ApoAl / ApoB, and obtain obvious effect of Lipid Modulation [3].. PFH of 3g/kg can significantly reduce the blood of mice with TC, TG and HDL-C, LDL-C levels, with lower lipids in mice [4]. The Polygala Total Saponin of 50mg/kg significantly prevent the rise of the polymer dextran acute blood stasis model rats and rabbits fed with high fat diet in whole blood viscosity, fibrinogen content, improve blood circulation [5]..Giving the total saponin of 50mg/kg to Bait Diet hyperlipidemia model quail for 35 days can reduce serum TC, TG andLDL-C and malondialdehyde (MDA),TG and TC in liver tissue , elevate serum HDL-C and NO content and enhance SOD activity [6]. 3. Inhibition Hepatitis B virus in vitro: different concentrations of PFH can inhibit the HsAg of hepatitis B surface antigen, the HbeAgin of hepatitis B e antigen in vitro,which the longer the contact time, the stronger the inhibition, but low concentration will weaken the effects of inhibition[7]. PFH of 3g/kg can significantly reduce serum alanine aminotransferase (ALT) ,aspartate aminotransferase (AST) activity of acute liver injury model of mice induced by the carbon tetrachloride, thioacetamide, paracetamol,and has a protective effect on liver injury [8]. 10 days of Polygala Total Saponin administration can reduce serum GOT and GPT levels of the carbon tetrachloride and galactosamine model mice, MDAcontent in liver tissue; administration 15 days to reduce GOT in mice of alcohol model of liver injury, TC and TG levels in serum and liver tissue.MDA and LDL levels in serum were significantly lower. SOD values were significantly increased, and hepatic pathology will improve [9]. 4. The impact on the symptoms of Meniere's disease (MD) model and the pathological model: the experiment of Vertigo model nystagmus induced the sine wave rotation administrated PFH (ig 3g/kg) in rabbits, indicating that the PFH on the slow phase velocity have a very significant impact,and eye shock duration significantly inhibited ,but the mean nystagmus frequency had no significant effect, suggesting that PFH increase vestibular excitation threshold,and improve vertigo. The guinea pig membranous labyrinth plot water caused by endolymphatic sac of surgery destruction, the hearing damage is significant after 50 days. Guinea pig auditory nerve compound potential (CAP) threshold was elevated, and latency are significantly inhibited by PFH (5g/kg) treatment for 20 days, and a certain increase CAP amplitude, suggesting the PFH can significantly improve hearing impairment of the guinea pig endolymphatic hydrops model. Therefore,PFH can alleviate the main symptoms of vertigo in MD, and can also improve hearing loss induced by the main pathological changes of endolymphatic [10].. 5. The influence on immune function: PTS of 50mg/kg can significantly increase the number of Th cell subsets of T cells in mice of low DTH responses induced by cyclophosphamide, increased the ratio of Th / Ts cell subsets, increase IL-2 production level ,and enhance the cellular immune function in mice [11].. Polygala fallax hemsl polysaccharide (PADTP) can enhance mononuclear phagocyte phagocytosis and promote antibody production, increase the lymphocyte transformation rate and enhance the immune function of normal mice [12]. PFH of 3g/kg can significantly increase in body weight of mice, thymus weight and thymus index [13]. 6. Anti-inflammatory: PFH of 4g/kg significantly inhibited ear edema of mice xylene-induced; PFH in 4,8g/kg dose could significantly inhibit the increase of skin permeability of the phosphate histamine-induced mouse;PFH of 4g/kg can remarkablly (PC) inhibit induced group of induced mice delayed type hypersensitivit. PFH in 4, 8g/kg dose inhibited significantly, very significantly attack group of trinitrochlorobenzene induced mouse delayed type hypersensitivity.PFH can inhibit the increase of vascular permeability caused by the inflammatory mediators or inflammatory response, but also suppress the immune inflammatory process, with obvious immune anti-inflammatory effects [1]. 7. The effect on myocardial function: the low concentration of PAD (10, 30%) have a certain improvement on pituitrin-induced rabbit acute myocardial ischemia , especially when given pituitary vasopressin 20 minutes was obvious, and reduce coronary resistance of isolated guinea pig heart, increase coronary flow, and high concentrations of PAD (60, 90%) make the barium chloride-induced ventricular arrhythmias in rats recovered to normal sinus rhythm, which 90% PAD show inhibition of the heart, and its role in myocardial cells rather than coronary artery [17].. 8. Anti-aging: Polygala fallax hemsl can increase SOD activity of mouse red blood cells, extending the swimming time of normal mice in the water and the weight of the spleen, adrenal and immune organs, with anti-aging effects [14].. 9. Anti-stress: Polygala fallax hemsl of 3g/kg can significantly extend the survival time of mice under the conditions of hypoxia tolerance ,the breathing space of decapitation mice, the survival time of subcutaneous injection of isoproterenol the mice at a regular pressure under hypoxic conditions, with significant hypoxia tolerance. PADTP can improve the body's adaptability to the stressor of hypoxia, low temperature ,high temperature,and improve the body's anti-stress ability [16].. 10: Others: Polygala fallax hemsl of 3g/kg have very significant inhibition to gastric membrane damage induced by ethanol, aspirin, flooding stress and reserpine, playing a protective role [18] . Polygala fallax hemsl saponin C preprocessed oxidized low density lipoprotein for four hours can inhibit the increases of cell adhesion rate of oxidized LDL-induced monocyte - endothelial, the increase of releasing asymmetric dimethyl arginine and tumor necrosis factor(TNF) and inhibition of human umbilical vein endothelial cells induced by oxidized low-density lipoprotein in endothelial cells hemagglutinin-like oxidized low-density lipoprotein receptor mRNA and protein expression, and showed a concentration-dependent [19, 20]. |
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[Clinical trial] | Late malignant tumor: In symptomatic,support based on conventional treatment, with HuangHuaDaoShuiLian to treat latemalignant tumor in 20 cases, oral, 1agent per day, 3 times per day, every three days or so take wuji tang. According to the specific condition, treat for 3 ~ 6 months.Results: the complete response was 2cases (10%), and some ease was 9 (45%), stable was 7 patients (35%), theeffective rate was 55%[1]. |
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[Properties] | ||
[Medical and other Uses] | ||
[Dosage] | ||
[Cautions] | ||
[Traditional usage] |
1.Insomnia 2.Chronic bronchitis 3.Pulmonary tuberculosis 4.Edema 5.Liver abscess 6.Malnutrition, edema 7.Wound 8.Agalactosis |
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[Toxicological studies] | ||
[Pharmaceutical preparations] | ||
[References] |
Chemical Composition: [1] Li Yaolan, Dai Jie, Huang Weihuan, Et Al. Fallax Chemical Composition And Its Antiviral Activity Of Chinese Herbal Medicine,2009,40(3):345-348. Pharmacological Effect: [1] Kou Junping, Ma Renqiang, Zhu Danni, Et Al. Fallax Water Extract, And Studies On The Anti Inflammatory Effect Of. Chinese Herbal Medicine,2003,26(4):268 [2] Kou Junping, Li Jingfeng, Yan Jin, Etc. Polygala Fallax Hemsl Total Saponins On Blood Coagulation And Thrombosis. Journal Of China Medicine University,2003,34(3):257 [3] Chen Xinyu, Huang Ultrasound Diagnosis, Yang Chunhua Fallax On Hyperlipidemia Patients, Low Density Lipoprotein And So On. Journal Of Hunan University Of Chinese Medicine,1999,19(3):33 [4] Li Liangdong, Li Hongliang, Fan Xiaona, Et Al. Polygala Fallax Hemsl On Lipids. Lishizhen Medicine And Materia Medica Research,2008,19(3):650 [5] Li Hao, Wang Qiujuan, Zhu Danni. Polygala Fallax Hemsl Total Glycosides In Blood Stasis Rats And Rabbits With Hyperlipidemia Blood Rheology. Chinese Journal Of Laboratory Medicine,2007,13(11):21 [6] Li Hao, Wang Qiujuan, Yuan Lin, Etc. Polygala Fallax Hemsl Total Saponins On Hyperlipidemia Model Lipid Metabolism. Chinese Journal Of Natural Medicine,2007,5(4):289 [7] Li Liping, Wang Weihua Fallax On Hepatitis B Virus E Antigen In Vitro Observation. Hunan Journal Of Traditional Chinese Medicine,1998,4(10):32 [8] Wang Xiaoli, Huang, Jiang Lixia, Et Al. Polygala Fallax Hemsl On Experimental Liver Injury Of Mice Protection. Lishizhen Medicine And Materia Medica Research,2007,18(6):1320 [9] Guo Jiyuan, Wang Qiujuan, Wu Jinhui, Et Al. Fallax Saponins On Experimental Liver Injury Of Animal Protection. Chinese Journal Of Natural Medicine,2006,4(4):303 [10] Kou Junping, Ma Renqiang, Zhu Danni, Et Al. Polygala Fallax Hemsl On Meniere's Disease Symptoms And Pathological Model Model . The Influence Of Chinese Folk Medicine Journal,2003(4):218 [11] Li Weizhen Fallax Saponins On Murine T Cell Subsets And IL-2. Journal Of Traditional Chinese Medicine,2002,27(3):219 [12] Qin Huazhen, Xia Xinhua Polygala Fallax Hemsl Polysaccharide On Immune Function Of Normal Mice. Chinese Herbal Medicine,1998,21(9):467 [13] He Yong, Li Hongliang, Yu And Accounted For, And So On. Polygala Fallax Hemsl On Mouse Immune Organs Of Rats. Journal Of Gannan School Of Medicine,2006,26(6):828 [14] Li Ping, Zhong Ming, Qiu Cuie. Huanghua Anti-Aging Effects . Yunnan Journal Of TCM,1996,16(4):13 [15] Zhu Qiuping, Li Hongliang, Fan Xiaona. Fallax Water Extract Of Hypoxia Tolerance Function Research. Journal Of Gannan School Of Medicine,2007,27(4):510 [16] Qin Huazhen, Xia Xinhua, Li Zhongwen. Polygala Fallax Hemsl Polysaccharide Anti Stress Effect Of Traditional Chinese Medicine In Guangxi,1996,19(3):52 [17] Guo Jiansheng, Li Zhongwen Fallax On Experimental Animal Myocardial Function Of Rats. Journal Of Hunan University Of Chinese Medicine,1992,12(3):40 [18] Fan Xiaona, Li Hongliang, Xiao Hai, And So On. Two Kinds Of Herbal Medicine On Experimental Gastric Mucosal Injury In Rats . Liaoning Journal Of TCM,2007,34(11):1648 [19] Bai Yongping, Zhang Guogang, Ishi Ruizhen, Et Al. Fallax Saponin C Inhibition Of Monocyte Adhesion To Endothelial Cells And Its Mechanism Of Action Research,2007,26(5):360 [20] Bai Yongping, Zhang Guogang, Ishi Ruizhen, Et Al. Fallax Saponin C Inhibited OX-LDL Induced LOX-1expression. Journal Of Central South University: Medical Sciences,2006,31(5):659 Clinical Trials: [1] Lei Guiqian, Meng Weiguang. Fallax Decoction In Treatment Of20 Cases Of Advanced Malignant Tumor. Journal Of Guangxi Traditional Chinese Medical University,2007,10(3):13 Toxicology: [1] Qin Huazhen, Xia Xinhua Polygala Fallax Hemsl Polysaccharide Extraction And Toxicology Research. Basic Med,1998,12(2):51 |