Location:Home > Blackberrglily Rhizome > [Chinese]
[English Name] Blackberrglily Rhizome
[Chinese Name] 射干  
[Pinying Name] Shegan  
[Latin Name] Belamcandae Rhizoma  
[Genera] Iridaceae
[Efficacy] Antipyretic drug
[Pictures] Plant picture Drug picture
Plant picture
 
Drug picture
 
[Alias]  
[Source]  
[Plant morphology]  
[Distribution]  
[Gathering and processing]  
[Characteristics]  
[Ecology]      It prefers warm and sunshine,resistants to drought and cold,no strict damand of soil,can be planted both in hillside and dry land,but the fertileloosewell-drained sandy soil with higher terrain is good. Neutral or slightly alkaline soil is optimum.It avoids low land and salinity-alkalinity land as taboos.It grows in hillsidegrasslandopen field land or is cultivated.  
[Chemical composition]  
[Pharmacological activities]

1Anti-inflammatoryThe alcoholextract from belamcandae had the inhibition effects on the early and late stageof inflammation[1-3]  

2Anti-pathogenic microorganism: 5% waterextracts from belamcandae and the average MIC were19.3% [4]. Diethyl ether extractsfrom belamcandae had the antifungal effect on the antifungal susceptibility diethyl etherextracts from belamcandae can destroy the cell wall[5,6]. Tectorigenin couldobviously inhibit the antifungal susceptibility effects, and the MIC were3.12~6.25% [7]. 10% alcohol extracts also inhibit the jingfang 86-1 influenza viruseffects [8].

3Digestive system and thrombosis effect: Belamcandae had weak anti-ulcer effectlasting choleretic effect. The role of small bowel diarrhea with anti-castoroil-induced stimulation of colorectal and small bowel diarrhea in animal modelsare, and the lasting effect [9]. Belamcandae had the strong antithromboticeffect, could significantly prolong the thrombus formation time [10].

4Female hormonal effects:Iridinand tectorigenin extracted from belamcandae,tectorigenin can be used as Female hormonal drugs of organic selection, selectivetreatment and prevention of cardiovascular disease (such as:atherosclerosis),osteoporosis and menopausal syndrome; Belamcandae extracts intravenousinjection can inhibit intermittent release of gonadotropin-releasing hormonefor ovariectomized mice, and inhibit the secretion of L-hour [9].

5EliminatingFree Radicals effect: The extracts from belamcandaehad antioxidant activity [11]. Isoflavonoids from Belamcanda chinensis including3′-hydroxy tectroridin, tectoridin, iridin and 3’, 4’, 5,7-tetrahydroxy-8-methoxyisoflavone had eliminating free radicals effect, especially tectoridinis the best for eliminatingO+2OH and H2O2 oxygen free radicals [12].

6 Antipyretic: Thebelamcandae ethanol extract intragastric infusion 13g/kg had theantipyretic effect on rat fever [8].

7 Theothers: Tectorigenin, wild Tectorigenin and its glycoside has a strong role of aldosereductase mechanism. Tectorigenin had the prevention and treatment effects of diabetessyndrome [13]. Belamcandal had stimulation the laryngeal mucosa effects, but belamcandal is unstable and is easy to decomposeand lose to stimulate the laryngeal mucosa effects in the drying process. Tectorigenin of belamcandae made as the main ingredient ofgranules can inhibit the rat passive cutaneous anaphylaxis induced byovalbumin. The belamcandae phenol A and B and allyl diketone components can enhancethe survival and growth of the acetylcholine nerve cells, and can enhance theactivity of acetylcholinesterase. Testosterone 5 alpha-reductase extracted frombelamcandae can be used for the treatmentof acne. Cytokinins made by belamcandae extract prevents skin aging,improve skin condition and to promote wound healing [1].

 
[Clinical trial]

 

Shegan (Belamcanda chinensis)
1. Acute injection of the upperrespiratory tract: The treatment group use the anti-viralinjection of shegan (Belamcanda chinensis) to treat 48 cases of acute injection of the upperrespiratory tract, add 8-10ml into250ml glucose or saline and intravenous, once a day. The control groupgiven the ribavirin intravenous to trea the acute injectionof the upper respiratory tract 48 cases,add 0.5g into 250ml glucose or salineand intravenous, once a day. Results: The total effective rateof treatment group was 95.8%, the total effective rate ofcontrol group was 81.3%, the total effectiverate was significant difference (P<0.05) [1].

2. Bronchial asthma: The conventional treatment group take aminophylline tablets(Oral, 0.1g every time, 3 times a day) and Ketotifen (Oral, 2mg every time, once every night) treated 47 cases bronchial asthma. In addition to the conventional treatmentof theophylline plusketotifen, the shegan group was given the decoction ofshegan, oral, 30ml every time, 3 times a day. Both the 2 groupswere treated for 4 weeks. Results: The course of disease in the shegan groupwas obviously shorter than the conventional treatment group, the clinicalsymptoms remission quickly, the main index of pulmonary function (FEV and PEF)improved obviously, the improvement of ECP was notably superior to theconventional treatment group [2].

3. Acute jaundice hepatitis: The treatment group use the juice of shegan (Belamcanda) (Dry goods 50g add 300ml water, decocted 20min and take the juice) to treat 66 acute jaundicehepatitis, 1agent a day, 3 times a day. The control group usethe yinchenhao soup add or subtract to treat 50 acute jaundice hepatitis, 1 agent a day, 3 times a day. 7 days as a courseof treatment, evaluated the curative effect 3 courses later. Results: 50 caseswere cured in the treatment group, account for 75.76%, 8 cases were improved,account for 12.27%, 8 cases were invalid, account for 12.27%. The totaleffective rate was 87.88%. The control group cured 30 cases, account for 60%, 9cases were improved, account for 18%, 11 cases were invalid, account for 22%.The total effective rate was 78%. Statistically, the totaleffective rate has significant difference in the2 groups (P<0.01) [3].

 
[Properties]  
[Medical and other Uses]  
[Dosage]  
[Cautions]  
[Traditional usage]

1.       Scorching and red carbuncle

2.       Acute mastitis at the early stage

3.       Arthritis, traumatic injury

4.       Scrofula due to accumulation of hot qi

5.       Parotitis

6.       Diphtheria

7.       Coughing with reverse flow of the lung qi and water sound in the throat

8.       The stomach heat with phlegm retention, vomiting due to blood accumulation

9.       Wind phlegm and salvia spitting of infant, asthma and cough, abdominal distension, and poor appetite. It was called horse lung wind with the syndromes of the lung distension, dyspnea with fullness sensation, shortness of breath with the chest rising up, shakiness of bilateral hypochondriac areas with the abdomen turning hollow, open of the nasal orifices, stuffiness and thirst, hoarseness and wet obstructive phlegm.

 
[Toxicological studies]  
[Pharmaceutical preparations]  
[References]

Pharmacology Actions:

[1] Wen-liang Ji, Min-jian Qin, Chemical and pharmacological research progress of Chinese medicine Belamcanda chinensis, Foreign medicine-herbal Volume, 2000, 15 (2): 57.

[2] Zhe-fang Wu, Zhao-mei Xiong, Belamcanda chinensis with white seal dry, Comparative Study of the pharmacological effects of the Sichuan seal dry, Pharmacology and Clinics of Chinese Materia Medica, 1990, 6 (6): 28.

[3] Information Center of the State Administration of Traditional Chinese herbal medicine station. Manual of herbal active ingredients. 1st edition. Beijing: People's Health Publishing House, 1986: 612.

[4] Hao Wang, Feng-qin Yang, 10 kinds of traditional Chinese medicine inhibitory experimental study of superficial fungal pathogenicity, Journal of Traditional Chinese Medicine, 1997, 38 (7): 431.

[5] Chun-ping Liu, Feng-rong Wang, Guo-rong Nan et al., Dermatophytes inhibitory effect Chinese medicine Belamcanda chinensis extract, Chinese Journal of Dermatology, 1998, 31 (5): 310.

[6] Chun-ping Liu, Guo-rong Nan, Feng-rong Wang et al., S Belamcanda chinensis of tinea bacterium electron microscopic observation, Chinese Journal of Dermatology, 1999, 32 (5): 341

[7] OH KB, Kang H. Detection of antifungal activity in Belamcanda chinensis by a single-cell bioassay method and isolation of its active compound tectorigenin. Biosci Biotechnol Biochem, 2001, 65 (4): 939.

[8] Zhe-fang Wu, Zhao-mei Xiong, Shegan and pharmacological effects of the white Shegan, the Sichuan Shegan (Iris) of Comparative Study, Pharmacology and Clinics of Chinese Materia Medica, 1990, 6 (6): 28

[9] Hong-wu Wang, Ming-fa Zhang, Ya-qin Shen et al., Impact of Shegan digestive and experimental thrombus, Research of Traditional Chinese Medicine, 1997, 13 (5): 431

[10] Ning Li, Ri-xin Zheng, Belamcanda chinensis diarrheogenic dosage discussion, Journal of Chinese Traditional Chinese Medicine, 1991, 16 (4): 2491.

[11] Yu-peng Liu, Mei Liu, Jun-ying Liu et al., Study on Antioxidant Activity of 30 Chinese Medicines, Journal o f Yantai University ( Natural Science and Engineering Edition) 2000, 13 (1): 70.

[12] Min-jian Qin, Wen-liang Ji, Jun Liu et al., Scavenging effects on radicals of isoflavones from rhizome of Belamcandae chinensis, Chinese Traditional and Herbal Drugs, 2003, 34 (7): 640.

[13] JungSh, Lee YS, Lee S, et al. Shin Kh Isoflavonoids from the rhizomes of Belamcandachinensis and their effects on aldose reductase and sorbitol accumulation in streptozotocin induced diabetic rat tissues.Arh Ph arm Res, 2002, 25 (3): 3061.
Clinical experiment 

[1] Zhu Baozhen Belamcandachinensis anti-viral injection inthe treatment of respiratorytract infection Efficacyof the Chinese community physicians, 2006(15): 43.

[2] Kuang militaryBelamcanda chinensis on the therapy the bronchial asthma and degranulationof eosinophils. ChinesePharmaceutical Affairs, 2007, 21 (12): 1026.

[3] Chen Fenglian. Belamcanda chinensis the treatment of acutejaundice hepatitis clinicalobservation of China NationalJournal of Medicine, 1997, 12 (3)Supplement: 65.