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[English Name] Chinese Honeylocust Fruit
[Chinese Name] 皂荚  
[Pinying Name] Zaojia  
[Latin Name] Fructus Gleditsiae  
[Genera] Leguminosae
[Efficacy] huatanyao
[Pictures] Plant picture Drug picture
Plant picture
 
Drug picture
 
[Alias] Changzaojia, Zaojiao, Dazaojia, Dazaojiao  
[Source]

This crude drug is the fruit of Gleditsia sinensis Lam. (family: Leguminosae).

 
[Plant morphology]  
[Distribution]

This species is distributed in Sichuan, Hebei, Shanxi and other areas in China.

 
[Gathering and processing]

After collected, the fruits are dried in the sun.

 
[Characteristics]  
[Ecology]     The characteristics are preferring light and resistanting to shade,preferring warm moist climate and thick fertileproperly wet soil,no strict damand of soil,can grow in all  calcific and salinity-alkalinity,even clay soil or sandy soil.Growth rate of Chinese Honeylocust Fruit is slow but life is very long, up to six hundred and seven hundred years.It is deep root tree.It needs nutrition of six to eight years to flower and bear fruit.But it’s  productive phase can be hundreds years long. Florescence is from April to August;  fructescence is in October.  
[Chemical composition]  
[Pharmacological activities]

1. Anticancer: Gleditisae sinensis extract can inhibit cell multiplication and promote apoptosis on human hepatoma carcinoma cell bel-7402[1-2].

2. Resistance to Hypoxia / Reoxygenation Injury: Gleditschiasaponin has resistance to hypoxia / reoxygenation injury and prtect fountion on cardiac muscle cell[3].

3. Prevent the Myocardial Ischemia: Gleditschiasaponin has marked prevent the acute myocardial ischemia acrivity on rat model induced by ligating the left anterior descending coronary[4].

4. Anti HIV and Mycoplasma Urealytium: Gleditschiasaponin crude extract show inhibit acitivity on mycoplasma urealytium and HIV-1 in vitro[5].

5. Expectorant: This medicine belong to nauseants;nauseous expectorant through reflectingly cause respiratory mucosa excretion increasing[6].

6. Antibiosis: Water extract can inhibit trichophyta and N asteroids proliferation[7].

 
[Clinical trial]

1. Hiccups: Zaojia(Chinese Honeylocust Fruit) for treatment of Hiccups,results: 71 cases were cured, accounted for 97.3%; 1 case was effective(1.4%);1 cases was invalid, accounting for 1.4%[1].

2.Malnutrition product: take dry skin thick qualitative hard smooth color deepbrown no moth of Zaojia (Chinese Honeylocust Fruit), 3 years old the following for 1 g per day, 3 ~ 6 years old daily for 2g, 6 years old of above daily  for 3 ~ 5g. Results: 4 weeks treatment increased appetite was 36 cases, 6 weeks appetiteincrease was 66 cases, all cases weight gain, achieves healthy son normalweight standard, all kinds of clinical symptoms and and disease were disappear,hemoglobin had also improved, after treatment for 89 ~ 130 g/L, an average of116.7 g/L[2]

3. Bonehyperplasia disease: Zaojia (Chinese Honeylocust Fruit)  immersion in liquors in standby,when using will be hard shear pound such as mud, with flour, then put in thegauze on applied to the affected part, according to the bone hyperplasia partsof the range of shittim determines how many, such as lumbar degenerative changefor 3 ~ 5 vertebral person with hard 5 ~ 7. Use 3 days change 1, the generaluse 2 times local swelling and pain can be basic relieve, can continue to stickapply 1 time to consolidate curative effect. Results: for all the 188 patients,123 cases were recovery, 12 cases were improved[3].

4.Kaschin-beck disease: with big Zaojia (ChineseHoneylocust Fruit)  toskin a three stringed plucked instrument silk, grinding fine a gross, refininghoney for 3 g heavy pill, each 3 ~ 6 g, 3 times per day, 1 month as 1 course oftreatment. after take medicine 1 course, 172 patients pain disappeared, jointfunction improved, including 82 cases of joint flexion was improved, andseriously ill patients with weak joints bend difficult to recover, butmedication adherence two treatment above, can make the pain stop and recoverywork. Take medicine according to the patient's constitution, in 3 ~ 6 g betweenmaster dose (more with less), children's discretionary with 0.5 ~ 3 g, noadverse reaction [4]

5. Infantilefastidium: take dry skin thick, qualitative smooth Zaojia (Chinese Honeylocust Fruit), dark brown, no moth ofshittim, brush do marl, broken, into the iron pot. First high heat, after slowfire burnt deposit quality, peeling the pod mouth, no birth within heart fordegrees, porphyrization for end with bottled. 1 g per time, 2 times per day,and with sugar. Mix well swallow. Results: the treatment of 110 cases werehealed in 86 cases, accounting for 78.1%; 18 cases wer better, accounting for16.4%, 6 cases were invalid  (5.5%), thetotal effective rate was 94.5% [5].

6.Trichomonas vaginitis: Zaojia (Chinese Honeylocust Fruit)50 g (pounding), Kushen 50 g, into 1000 ml water, Fried 15 min, strikewhile first smoked, when temperature and washing privates, 1 time per night.The method for 3 months. Results the recent 39 cases were cured, long-term curein 12 cases, total cure rate was 75%[6] .

 
[Properties]  
[Medical and other Uses]  
[Dosage]  
[Cautions]  
[Traditional usage]  
[Toxicological studies]  
[Pharmaceutical preparations]  
[References]

Pharmacologic Actions:

[1] Zhang Zhenyu, Zhang Chizhi, Xu Hanlin. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases, 2008,18(2):93.

[2] Zaki Hirohide. Japana Centra Revuo Medicina, 1954,108:17.

[3] Chen Shengwu, Ding Yunlu, Song Yu, et al. Traditional Chinese Drug Research & Clinical Pharmacology, 2007,18(6):442.

[4] Ding Yunlu, Wang Yan, Hao Yufang, et al. Chinese Journal of New Drugs and Clinical Remedies, 2006, 25(2):110.

[5] Zhao Shenglan, Chen Chaoyin, Dong Qijiang, et al. Shaanxi Journal of Traditional Chinese Medicine, 2007,28(7):923.

[6] Gao Yingfeng. National Medical Journal of China, 1954,(5):331.

[7] Cao Renlie. Chinese Journal of Dermatology, 1957,(4):286.

[8] Zhang Hongli, Han Chongxuan, Yang Xuejun, et al. Acta Agriculturae Boreali-Occidentalis Sinica, 2005,14(4):117.

[9] Wen Jinacheng. Chinese Journal of Pathology, 1956,2(1):38.

[10] Guo Xiaozhuang. Dictionary of toxic Chinese herbal medicine. Tianjin Science and Technology Translation Publishing Corporation, 1992:512.

Clinical trials:

[1]LIU Xi-zhen,LIU Yinpu .The report on Zaojia for treatment of Hiccupsin 73 cases . Journal of Chinese Medicinal Materials.1994, 17(6):49.

 [2]WANG Shibiao,HE Jihong. Zaojia fortreatment of Malnutrition product. Journal of Traditional Chin Medicine,1995,367:390.

 [3]LU Wanren. Zaojia for treatmentof Bone hyperplasia disease in 188cases. Zhejiang Journal of TraditionalChinese Medicine,19955:229.

 [4]JI Keqin. Zaojia for treatment of  Beck disease and syndrome. Journal ofTraditional Chinese Medicine,

.1995, 366:326.

 [5]WAG Yikui. Zaojia for treatmentof Infantile fastidium in 110 cases.Hubei Journal of Traditional ChineseMedicine,1987,(!):25.

 [6]YI Xujun,YI Hao,ZHANG Dexiu.Zaojiakushenye for treatment of Trichomonas vaginitis in 68 cases.Gansu Journalof Traditional Chinese Medicine,1996,9(3):35.