1. Immunoloregulation：Achyranthes bidentata blume polysaccharide(ABPS) show a elevate mononuclear macrophage phagocytize activity on mice model[1]. It show immune enhancement on cancer mice model induced by S180 or H22[2,3]. In addition, It show immune enhancement on aged rats model also[4].

2. Effect on Uterus and Antifertility: Achyranthes bidentata saponins A(ABSA) show an excited activity on uterus smooth muscle through inhibit 5-HT and prostaglandin synthesis and release[5,6]. In addition, the ABSA, benzene and chloroform extract show obviously antifertility and antiearly pregnancy activity on animal model[7,8].

3. Stay Caducity: Achyranthes bidentata show a Stay Caducity activity on bombyx mori Linnaeus, chicken or old mice or cell model[9-12]. The water extract can obviously improve mice memory disorders induced by napental[13].

4. Anticancer: ABPS show significant elevate LAK cell cytoactive and cell membrane sialic acid level, cut down membrane phospholipids content activity on S180 model[1,14]. Its total saponin(APS) show a inhibit ehrlich ascite tumor cell, hepatoma and S180 activity on mice model or in vitro[15].

5. Analgesia and Antiinflammatory: Different place or processed product of twotoothed achyranthes root and APS show certain degree analgesia[16-18]. The prepared Radix Achyranthis Bidentatae with yellow rice wine and root extract show anti-inflammatory on animal model[19].

6. Effect on Hematological System: achyranthes bidentata possess improve blood rheology and activating blood circulation to dissipate blood stasis activity[20-22].

7.Anti Viruses: The sulfate id ABPS can inhibit herpes simplex virus, hepatitis b virus and hepatitis b e antigens[23,24].

8. Effect on Cardiovascular System: Achyranthes bidentata can temporary expand blood vessels. The water extract can expand lower extremity blood vessels.[25,26]. In addition, Achyranthes bidentata show antiatherosclerotic activity on atherosclerotic quail model induced by high lipoid food[27].

9. Effect on Nervous System: There is a nerve growth factor(NGF) competitive inhibitor contains in achyranthes bidentata. It can inhibit the combination of NGF and

its acceptor[28].

10. Hypoglycemic: Water extract can down regulation the mRNA expression of P75 gene on Type 2 diabetes mellitus rat brain tissue[29].

11.Other Activity: Achyranthes bidentata can strengthen respiratory intensity and frequency[23].

1. Sciatica: 86 cases in treatment group received “Danggui Sini Decoction” and Achyranthis Bidentatae Radix (Angelicae Sinensis Radix, Cmnamomi Ramulus, Radix Paeoniae Rubra, Asari Radix Et Rhizoma, Glycyrrhizae Radix Et Rhizoma, Tetrapanacis Medulla and Achyranthis Bidentatae Radix etc.), which was decocted with water, one prescription for 2 doses a day, 6 prescriptions made up one course. Results: The total effective rate was 95.35%, 54 cases cured , 28 cases improved, 4 cases invalided; The treatment time ranged from one course to five courses with an average of three courses. After 6 months to 4 years follow up, 29 cases relapsed, accounting for 33.72 percent, and all cases recovered after^[1]。

2.Primary Dysmenorrhea: The patients in the treatment group received “NiuXi Powders” (Radix Achyranthis Bidentatae, Guixin, Radix Paeoniae Rubra, Semen Juglandis, Rhizoma Corydalis, Angelicae Sinensis Radix, Radix Aucklandiae and Moutan Cortex etc.), 9g each time, taken it with warm wine or water, plus locally fomentation. The patients in the control group received acupuncture at “Hegu” and “San yin jiao” acupoints for treatment. 36 cases in the treatment group, 17 cases in the control group, 5 days for 1 course. Results: In the treatment group, 17 cases cured(47.13%), 15 cases improved(41.13%), and 4 cases invalided(11.14%), the total effective rate was 88.16%. In the control group, 3 cases cured(17.11%), 8 cases improved(47.11%) and 6 cases invalided(34.18%), the total efficiency rate was 65.12%. The treatment group was better than control group(P<0.05)^[2]

3.Arthritis: 25 cases with Arthritis taken the water decoction of Achyranthis Bidentatae Radix orally in the morning and evening daily, plus hot compress with the water decoction of Cyathulae Radix. Results: The total effective rate was 96%, 20 cases cured(80%), 4 cases improved(16%), 4 cases invalided(4%)^[3].

4.Urinary Calculi: 56 cases with Urinary Calculi in treatment group received “NiuXi Decoction” (Achyranthis Bidentatae Radix, Qlibanum, Myrrha, Lysimachiae Herba, Galli Gigerii Endothelium, Lygodii Spora), which was decocted with water, one prescription for 1 doses at 1 hour after supper. Second day 56 cases drank much water, and done some jump in order to discharge the calculus. 28 cases with Urinary Calculi in the control group received “Fufang Shilin Tong Tablet”, 3 times a day, 4 tablets each time. 10 days for 1 courses, the treatment time ranged from 1 to 3 courses. Results: In the treatment group, 43 cases cured, 10 cases improved, and 3 cases invalided, the total effective rate was 94.6%. the time of discharging calculus ranged from 2 days to 30 days after taking the “NiuXi Decoction”, with an average of 15 days;

In the control group, 13 cases cured, 12 cases improved, and 3 cases invalided, the total effective rate was 89.3%. the time of discharging calculus ranged from 7 days to 30 days after taking the “NiuXi Decoction”, with an average of 18 days^[4].

5.Acute Cerebral Infarction: The cases in the treatment group receivd “Niuxi Xiaoshuan Decoction”(Achyranthis Bidentatae Radix, Astmgali Radix, Angelicae Sinensis Radix, Radix Paeoniae Rubra, Paeoniae Radix Alba, Ramulus Uncariae Cum Uncis, Gardeniae Fructus, Acori Tatarinowii Rhizoma, Glycyrrhizae Radix Et Rhizoma etc.), which was decocted with water, one prescription for 2 doses a day, combined with intravenous drip with “Zheng Kang Nao Ming Injection” for 2 times a day. Results: The treatment group was significantly better than the control group (P<0.05)^[5].

Chemical Composition:

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[2]ZHAO Wan-Ting,MENG Da-Li,LI Xian,LI Wei Chemical Constituents Of Achyranthes Bidentata Bl．Journal Of Shenyang Pharmaceutical University，2007,24(4):207．

[3]LIN Da-Zhuan, WANG Guang-Shu,YANG Xiao-Hong, Studies On Steroid Constituents Of Achyranthes Bientata Bl．Chinese Pharmaceutical Journal，2006,41(17):1295．

[4]MENG Da-Li,HOU Bai-Ling,WANG Yi．Phytosterone Constituents From Achyranthese Bidentata Bl. Journal Of Shenyang Pharmaceutical University，2006,23(9):562．

[5]WANG Guang-Shu,CONG Deng-Li,YANG Jin-Zhu. The Triterpenoid Saponins In Achyranthes Bientata Bl．Chinese Journal Of Medicinal Chemistry，2005,15(4):224．

[6]WANG Guang-Shu, ZHOU Xiao-Ping, YANG Xiao-Hong．Study On The Acidic Triterpenoid Saponins Of Achyranthes Bientata Bl.Chinese Journal Of Medicinal Chemistry,2004,14(1):40．

[7]MENG Da Li,LI Xian,XIONG Yin Hua,Et Al. Study On The Chemical Constituents Of Achyranthes Bidentata Bl. Journal Of Shenyang Pharmaceutical University, 2002,19(1):27．

[8]State Administration Of Traditional Chinese Medicine Material Medical Editorial Board .Chinese Material Medical .Shanghai: Shanghai Scientific And Technical Publishers，1999,4:830(Total 1482)．