Location:Home > Kelp > [Chinese]
[English Name] Kelp
[Chinese Name] 昆布  
[Pinying Name] Kunbu  
[Latin Name] Laminariae Japonicae Thallus  
[Genera] haidaike
[Efficacy] huatanyao
[Pictures] Plant picture Drug picture
Plant picture
 
Drug picture
 
[Alias]  
[Source]  
[Plant morphology]  
[Distribution]  
[Gathering and processing]  
[Characteristics]  
[Ecology]     Kelp originally is cold-water tolerance alga.It’s growth temperature is between 0 to 13,and the optimum is between 2 to 7.  
[Chemical composition]  
[Pharmacological activities]

1. Effect on Cardiovascular System: oleic acid, myristic acid, palmitic acid and dihydrogen iodate histamine show periaqueductal gray stimulation on isolate heart[1]. Laminine show decreased the blood pressure effect[2-6].

2.Reducing Blood Lipid: Water extract show reducing blood lipid action on Hyperlipoproteinemia rabbit and rat model[7,8]. Diethyl ether and alcohol extract, Alginate sodium and lamarin, laminarin sulfate show similarity effect also[3,8-11].

3. Anticoagulated blood: :Lamarin and laminarin sulfate show thrombosis activity in vivo and vitro through inhibit thrombin and Plasmin inhibitor activity[7, 10, 12-17].

4.Effect on Immune Function: laminarin and its’ sulfate can enhance macrophage phagocytize and lymphocyte transformation[13]. Angustate Laminaria water extract can enhance macrophage phagocytize erythrocytolysin and white cell level[18]. Alginate sodium and fucose in polysaccharide can enhance immune function[9,19].

5. Anticancer: Kelp show anticancer effect on mice breast cancer[20], fleshy tumor S180[21] and leukemia L1210[3]in vivo and lung cancer cell in vitro[11]. Alginate sodium and lamarin show anticancer activity on mice fleshy tumor S180[9-10]. Viva-natural extract can inhibit AKRT leukemia cell line[22].

6.Hypoglycemic: laminarin show hypoglycemic activity on normal and alloxan induced hyperglycemia mice[23].

7.Effect on Intestines Smooth Muscle: Laminine show papaverine like effect on mice isolated small intestine[4].

8. Radioprotective: alginate sodium and laminarin show a radioprotective on γradiation exposure mice[17,12,24].

9.Other Action: Laminarin can enhance hematopoietic activity[24]. alginate sodium can used as dextran for plasma substitutes[11]. Its extract show anti-mutagenesis[25], antioxidant[26,27] and induced labor[28].

 
[Clinical trial]

1. Infusion phlebitisdry Haidai(Kelp ) for treatment of infusion phlebitis. Results: treatment group for 3days that 25 cases were cured, 12 cases were markedly improved, effective in 7patients, 1 case ineffective.

2. Chronic tracheitis: Haidai(Kelp ) root water pill for  treatmentof chronic bronchitis in 92 cases, 1 agent per day, 10 days as  1  course of treatment,  for two courses. Results: a course oftreatment, 26 cases were nearly controled (28.2%), 17 cases were powerfully(19.6%), 31 patients wer improved (33.7%), 18 cases were invalid (19.5%), theeffective rate was 80.5%, significant efficiency was 47.8%; for two courses, 33patients were nearly controled (37.5%), 21 cases were powerfully (23.9%), 18cases were improved (20.4%), 16 cases were invalid (18.2%). 

 
[Properties]  
[Medical and other Uses]  
[Dosage]  
[Cautions]  
[Traditional usage]  
[Toxicological studies]  
[Pharmaceutical preparations]  
[References]

Pharmacologic Actions:

[1] Takuo Kosuge. Journal of Pharmacy(Japan), 1983,103(6):683.

[2] Shandong Institute of marine pharmaceutical group. Chinese Traditional and Herbal Drugs, 1972,(6):313.

[3]  Li Qinghua. World Phytomedicines, 1982,(4):9.

[4] Gomi Paul Southern. Japana Centra Revuo Medicina, 1967,224:462.

[5] Liu Changfa. Chinese Journal of Marine Drugs, 1993,12(1):47.

[6] Guo Jian. World Phytomedicines, 1989,4(2):87.

[7] Tang Shaoli, Shen Shiqin. Modern Journal of Integrated Traditional Chinese and Western Medicine, 1989,9(4):223.

[8] Zhang Rongrui, Hua Yili, Feng Qunguang. Journal of Nanjing University of Traditional Chinese Medicine, 1988,(4):57.

[9] Fan Manfang, Chen Qionghua. Journal of China Pharmaceutical University, 1988,19(4):279.

[10] Deng Huaichun. Chinese Traditional and Herbal Drugs, 1987,18(2):15.

[11] Chinese people's Liberation Army Logistics Department of Health.  Chinese Medicinal Marine Organisms. Shanghai: Shanghai people's Publishing House, 1977:12,14,16.

[12] Fan Manhua, Chen Qionghua. Journal of China Pharmaceutical University,1988,19(1):30.

[13]Mori H.C A,1983,98:137414f.

[14]Nishino T, et al. C A,1989,110:189407s.

[15]Fukuyama Y,et al.Chem Pharm Bull,1989,37(9):2438;1990,38(1):133.

[16]Mishimo T. C A,1991,114:118564n.

[17] Pei Yuanying. Chinese Traditional and Herbal Drugs, 1981,12(4):185.

[18] Zhang Shumei. World Phytomedicines, 1981,2(1):43.

[19] Yang Xiaolin. Chinese Pharmacologist, 1992,9(3):67.

[20] Zhang Jingbo. International Journal of Traditional Chinese Medicine, 1984,6(2):18.

[21]Yamamoto I. Japan J Exp Med,1974, 44(6):543.

[22]Furusawa E. C A, 1988,109,47934s.

[23] Xue Huaijian, Yang Wen, Chen Qionghua. Journal of China Pharmaceutical University, 1989,20(6):378.

[24] Deng Huaichun. Chinese Journal of Radiological Medicine and Protection, 1987,7(1):49.

[25] Liu Zhongze. Chinese Journal of Marine Drugs, 1987,6(2):88.

[26]Fujimoto K . C A,1980. 93:201041h.

[27]Nishibori S. C A, 1986, 104:147414n.

[28] Ye Bilv, J.E.Tyson. Journal of Wenzhou Medical College, 1982,(1):23.

Clinical trials:

[1] HE Yufen. The observation on Haidai for treatment of infusionphlebitis. Inner Mongolia Medical Journal, 2007,39(7): 893-894.

[2] Fujian YiDa affiliated first hospital chronic bronchitis control group .Fufanghaidaigendiwan for treatment of Chronic tracheitis in 92 cases. Journal of Fujian Medical University,1975,(3):48-50