1. The extracts from Fructus Mume and the main triterpenoid component ursolic acid showe the  inhibitive effect on proliferation of HLMeg and HL-60 cells^[1].

2. The water extract of Prunus mume (fruit) exhibits the wormicidal effect on Clonorchis sinensis^[2].

3. Prunus mume (fruit) exhibits the antibacteria effect such as shigella dysenteriae, escherichia coli, typhoid bacillus, Bordetella pertussis, diplococcus meningitides, tubercle bacillus, fungus and so on^[3,4].

4. Dark plum dose dependently increased the resting tension and the contractile frequency of isolated bladder detrusor muscle strips of guinea pigs^[5]. The decoction of Fructus Mume could enlarge the average amplitude of slow wave of uterine smooth muscle myoelectricity as well as increase the incidence and the maximal amplitude of the outbreak plexiform myoelectric wave^[6].

5. The kernel shuck and seed Fructus Mume could prevent cough, the pulp of Fructus Mume is effective on bowel astringent, and the pulp and kernel shuck of Fructus Mume are effective on antidiarrh

ea^[7].

6. The water extract of Fructus Mume could weaken the effects of attacking factors on the gastric mucus^[8].

1.Resistant itching：Wumei(Fructus Mume) was made into powder ,take it after mixing with water.7 days as one course of treatment. Results showed in 100 cases of patients, 43 cases patients were cured after a course, 38 cases patients were cured after two courses,19 cases patients were cured after three courses,The overall effective rate was 100% ^[1]。

2. Heel pain：heel was soaked with Wumei(Fructus Mume) decoction Added vinegar quantity. Results showed in 286 cases of patients, The overall effective rate was over 90% ^[2]。

3.corns：①37 cases were treated with Wumei(Fructus Mume) meat for external use. Results showed that all patients were cured and last 7 days~14days,34 cases was 10 days,2 cases was 14 days,1case recurred after curing^[3]。②30 cases were treated with Wumei(Fructus Mume) meat added vinegar for external use. Change daily once. Results showed that all patients were effective in 3 ~ 5 days ^[4].

③198 cases were treated with Wumei(Fructus Mume) meat added vinegar for external use. Change daily once. 7 days as one course of treatment. patients were treat with 1～3 course of treatment. Results showed that 178 cases were cured, accounting for 90%；20 cases were invalid , accounting for 10%^[5]。

4. Verruca plana：67 cases were treated with Wumei(Fructus Mume) and Gusuibu(Fortune's Drynaria Rhizome ),both added vinegar for external use. 3 ~ 4 times daily. 10 days as one course of treatment. Results showed that 46 cases were cured, 19 cases had effect； 3 cases were invalid because of Not adhering to treatment.The overall effective rate was 95.5% ^[6]。

5. Resistant scabies：30 cases were treated with Wumei(Fructus Mume) added vinegar for external use.4 days as one course of treatment. Results showed that the rash and itching disappeared and the course of the treatment group was 12～25 days.The curative rate was 100% .There was no recurrence during the followup 2 years ^[7].

6. Vitiligo：28 cases were treated with Wumei(Fructus Mume) wine for external use Combining with Xiaobai decoction (Baizhi(Radix Angelicae dahuricae),Fangfeng(radix sileris) , Baijili (tribulus terrestris)，Buguzhi(Malaytea Scurfpea Fruit)，Danggui(angelica sinensis)，Huangqi(radix astragali)，Shengdi(Radix Rehmanniae)，Danshen(Salvia Miltiorrhiza Bge)，Nuzhenzi（Glossy Privet Fruit），etc).3 ~ 4 times daily. 3 months as one course of treatment. Patients were treated with two course of treatment continually. Results showed that 8 cases were cured, accounting for 28.57%；7 cases had significant effect, accounting for 25%；8 had effect, accounting for 28.57%.5 cases were invalid, accounting for 17.14%. The overall effective rate was 82.14% ^[8]。

7. Vertigo：28 cases were treated with a prescription based on Wumei(Fructus Mume) pill,added wuweizi, guiyuanrou(longan), jingjie(Schizonepeta tenuifolia), Huangqi(radix astragali),Danggui(angelica sinensis),etc.Results showed that 180 cases were cured, 45 had effect, 3 cases were invalid. The overall effective rate was 98.7％^[9]。

8.Migraines：48 cases were treated with a prescription (Wumei(Fructus Mume), xixin (Asarum), gangjiang(Rhizoma Zingiberis), huanglian(Coptidis Rhizoma), Danggui(angelica sinensis), fuzi(Radix Aconite Lateralis Preparata), shujiao(pepper),guizhi(Cassia Twig),etc).Results showed that 25 cases were cured, accounting for 52.1%；12 cases had significant effect, accounting for 25%；7 cases improved, accounting for 14.6%. 4 cases were invalid, accounting for 8.3%. The overall effective rate was 91.7%^[10]。

9．Child Anorexia：66 cases were treated with a prescription (Wumei(Fructus Mume), nanshashen(adenophora tetraphylla), mugua(Chinese Floweringquice Fruit), Lianzi(Lotus Thalamous Seed), shanyao(Rhizoma Dioscoreae), baibiandou (Dolichos Lablab),gancao(radix glycyrrhizae),etc). 7 days as one course of treatment. Results showed that 54 cases had significant effect, accounting for 82%；12 had effect, accounting for 18%. The overall effective rate was 100%^[10]。

10．Child functional recurrent abdominal pain：117 cases were treated with a prescription (Wumei (Mumeplant Blossom or Fruit), xixin(Asarum), fuzi(Radix Aconite Lateralis Preparata), huanglian(Coptidis Rhizoma), Danggui(angelica sinensis), guizhi(Cassia Twig) ,gangjiang(Rhizoma Zingiberis), etc). 4 weeks as one course of treatment. Results showed that 78 cases were cured, accounting for 66.67%； 32 had effect, accounting for 27.35%%. 7 cases were invalid, accounting for 6.0%. The overall effective rate was 94.02%^[12]。

11. Child H. pylori infection gastritis：94 cases were treated with a prescription (Wumei (Mumeplant Blossom or Fruit), huangqin (radix scutellariae), muxiang (Radix aucklandiae), jinling (Melia toosendan), chuangmutong (Caulis Clematidis Armandii), sugeng (Cultivated Purple Perilla Herb), binglan (Semen Arecae), yanhusuo (Corydalis), etc). 4 weeks as one course of treatment. Results showed that 85 cases were cured, accounting for 90.42% ^[13]。

12. Infant chronic diarrhea：50 cases were treated with a prescription (Wumei(Fructus Mume), gangjiang(Rhizoma Zingiberis), huanglian(Coptidis Rhizoma), shujiao(pepper), guizhi(Cassia Twig), dangshen(radix codonopsis), baizhu(Atractylodes macrocephala koidz), wuweizi(Schisandra), etc). After 3 days treatment,results showed that 32 cases had significant effect,14 had effect, 4 cases were invalid.The overall effective rate was 92％^[14]。

13. Type-2 diabetes mellitus：500 cases were treated with meihuaxiaotanglin (Wumei (Mumeplant Blossom or Fruit), tianhuafen(Radix trichosanthis), Huangqi(radix astragali), maidong(Dwarf Lilyturf Root Tuber), taizishen( radix pseudostellariae), shuizhi(Hirudo), jiangchan(Bombyx batryticatus), baizhu(Atractylodes macrocephala koidz), etc). 3 months as one course of treatment. Results showed that 275 cases had significant effect,190 had effect, 35 cases were invalid.The overall effective rate was93％^[15]。

14. IGT： 20 cases were treated with a prescription (Wumei(Fructus Mume), shaoyao(Herba Peony), jinyingzi(Cherokee Rose Fruit), shanzhuyu(Cornus officinalis), dangshen(radix codonopsis), baizhu(Atractylodes macrocephala koidz), shanyao(Rhizoma Dioscoreae),etc). 2 weeks as one course of treatment. Results showed that 14 cases had significant effect, 4 cases improved, 2 cases were invalid. The overall effective rate was 90％^[16]。

15. Gastroptosis：①35 cases were treated with a prescription (Wumei(Fructus Mume), mopancao(Chingma Abutilon Seed), huangjing(King Solomonseal Rhizome), Shengdi(Radix Rehmanniae), baishao( white Herba Peony), zhike(Fructus Aurantii),chishao( red Herba Peony),Shudi(Radix Rehmannia ) ,shashen (adenophora stricta),gancao(radix glycyrrhizae),etc). 10 days as one course of treatment. Results showed that 35 cases were cured, 12 cases had significant effect,5 had effect ^[17]。

②20 cases were treated with a prescription (Wumei(Fructus Mume), Shudi(Radix Rehmanniae), Danggui (angelica sinensis), baishao( white Herba Peony), chuanxiong(Rhizoma Chuanxiong),etc). 13 days as one course of treatment. Results showed that 15 cases patients were cured after l～2 courses,2 cases patients were cured after 3 courses,2 cases patients were cured after 4 courses, 1 cases patients were cured after over 5 courses .15 cases were cured, accounting for 25%；4 cases improved,accounting for 20%；1 cases were invalid，accounting for 5%，The overall effective rate was 95% ^[18]。

③58 cases were treated with a prescription (Wumei(Fructus Mume), baishao( white Herba Peony), sanqi(Panax notoginseng), Shengdi(Radix Rehmanniae), zhike(Fructus Aurantii), foshou(finger citron), baizhu(Atractylodes macrocephala koidz) ,etc). 20 days as one course of treatment. Results showed that 39 cases were cured, accounting for 67.2%；17 cases had effect，accounting for 29.3%；2 cases were invalid，accounting for 3.4%，The overall effective rate was 96.5% There was no recurrence during the followup 2 years ^[19]。

16. Taenia solium：7 cases were treated with a prescription (Wumei(Fructus Mume), binglan (Semen Arecae),shiliupi ( granatum),leiwan (stone-like omphalia),shijunzi(Rangooncreeper Fruit),etc). Results showed that head body tail of tapeworm were complete in 6 cases due to good Clinical coordination after anthelmintic by microscope observation;tapeworm head were not observated due to younger age^[20]。

17. Gallstones： 40 cases were treated with a prescription (Wumei(Fructus Mume), Huangqi (radix astragali), baizhu(Atractylodes macrocephala koidz), dangshen(radix codonopsis), baishao( white Herba Peony), mugua(Chinese Floweringquice Fruit), zizi(Cape Jasmine Fruit), etc) made into pills. Results showed that 9 cases were cured,15 cases had significant effect,  11cases had effect，5 cases were invalid.The overall effective rate was 87.5％^[21]。

18. Chronic cholecystitis： 69 cases were treated with a prescription (Wumei(Fructus Mume), xixin (Asarum), gangjiang(Rhizoma Zingiberis), guizhi(Cassia Twig), fuzi(Radix Aconite Lateralis Preparata), huajiao(pepper), huanglian(Coptidis Rhizoma) , huangbo(cortex phellodendri), dangshen(radix codonopsis), Danggui(angelica sinensis),etc).10 days as one course of treatment. Results showed that 51 cases were cured, 13 cases had significant effect,5 cases were invalid. The overall effective rate was 92.8％^[22]。

19. Biliary ascariasis：47 cases were treated with a prescription (Wumei(Fructus Mume), yinchen(Capillary Wormwood Herb), shijunzi(Rangooncreeper Fruit), etc). 3 days as one course of treatment. Results showed that 45 cases were cured, 2 cases had significant effect. The overall effective rate was 100％^[23]。

20. Chronic ulcerative colitis： 47 cases were treated with a prescription (wumei, huanglian(Coptidis Rhizoma), huangbo(cortex phellodendri), rougui(Cinnamon), fuzi(Radix Aconite Lateralis Preparata) , chuanjiao(pepper),xixin(Asarum),etc).Results showed that 15 cases were cured, 28 cases improved ,4 cases were invalid. The overall effective rate was 93.6％^[24]。

21. Chronic atrophic gastritis：78 cases were treated with a prescription (Wumei(Fructus Mume), dangshen (radix codonopsis), Danggui(angelica sinensis), guizhi(Cassia Twig), gangjiang(Rhizoma zingiberis), chuanjiao (pepper),etc). 3 months as one course of treatment. (no other treatment for stomach during treatment ).Results showed that 32 cases had significant effect. 38 cases had effect, 8cases were invalid. The overall effective rate was 89.7％^[25]。

22. Constipation type bowel autism syndrome：31 cases were treated with a prescription (wumei (Fructus Mume), gangjiang(Rhizoma Zingiberis), xixin(Asarum), guizhi(Cassia Twig), fuzi(Radix Aconite Lateralis Preparata), huajiao(pepper), huanglian(Coptidis Rhizoma) ,etc). 30 days as one course of treatment. Results showed that 17 cases were cured, accounting for 54.8%；10 cases had effect，accounting for 32.3%；4 cases were invalid，accounting for 12.9%，The overall effective rate was 87.1%^[26]。

22. Crohn Disease：21 cases were treated with a prescription (Wumei(Fructus Mume), xixin(Asarum) , gangjiang (Rhizoma Zingiberis), huanglian(Coptidis Rhizoma), huangbo(cortex phellodendri), fuzi(Radix Aconite Lateralis Preparata),etc). 15 days as one course of treatment. 3 courses of treatment continually. Results showed that 16 cases were cured, accounting for 76.2%；4 cases improved，accounting for19%；1 cases were invalid. The overall effective rate was 95.2%^[27]。

24. Predawn diarrhea：48 cases were treated with Wumei granule (wumei(Fructus Mume), gangjiang(Rhizoma Zingiberis), xixin(Asarum), guizhi(Cassia Twig), fuzi((Radix Aconite Lateralis Preparata), huajiao(pepper),etc). 30 days as one course of treatment. Follow-ups lasted 1 month, combining with applying Shenque plaster on acupoint Shenque. Results showed that 33 cases were cured, 13cases improved，2 cases were invalid. The overall effective rate was95.9%^[28]。

25. Chronic bacterium dysentery：38 cases were treated with a prescription (Wumei (Fructus Mume), xixin(Asarum),gangjiang(Rhizoma Zingiberis), huanglian(Coptidis Rhizoma), Danggui(angelica sinensis), fuzi((Radix Aconite Lateralis Preparata), chuanjiao(pepper), guizhi (Cassia Twig),etc). 15 days as one course of treatment. Then it made into pills, 3 months of treatment continually. Results showed that 19 cases were cured, 17cases had effect2 cases were invalid. The overall effective rate was94.7％. During treatment, No injury of liver and renal function or others happened^[29]。.

26. Irregular menstruation： ①60 cases were treated with a prescription (Wumei(Fructus Mume), xixin(Asarum),gangjiang(Rhizoma Zingiberis), huanglian(Coptidis Rhizoma), Danggui(angelica sinensis), fuzi(Radix Aconite Lateralis Preparata), shujiao(pepper), guizhi(Cassia Twig),etc). Results showed that 47 cases were cured, accounting for 70%；12 cases had significant effect，accounting for 20%；4 cases had effect ，accounting for 6.7%；2 cases were invalid，accounting for 3.3%.The overall effective rate was 97%^[30]。②47 cases were treated with a prescription (Wumei(Fructus Mume), sangpiaoxiao(mantis egg- case) , jinyingzi(Cherokee Rose Fruit), chuangjiao(pepper), gangjiang(Rhizoma Zingiberis), fuzi(Radix Aconite Lateralis Preparata),guizhi(Cassia Twig),huanglian(Coptidis Rhizoma), etc). 10 days as one course of treatment. Results showed that 21 cases were cured, accounting for 44.7%；24 cases had effect，accounting for 51.1%；2 cases were invalid，accounting for 4.3%.The overall effective rate was 95.7%^[31]。

27. Postpartum body pain： 35 cases were treated with a prescription (Wumei(Fructus Mume), luxiancao (pyrola), baishao( white Herba Peony), Huangqi(radix astragali),lujiao(antler), Danggui(angelica sinensis) ,gancao (radix glycyrrhizae), etc). Results showed that after 5～15 days treatment,33 cases were cured, 2 cases improved ^[32] .

28.chronic pelvic inflammation：①46 cases were treated with a prescription for enema (Wumei(Fructus Mume), Danggui(angelica sinensis), huangbo(cortex phellodendri), dangshen(radix codonopsis), fuzi (Radix Aconite Lateralis Preparata), gangjiang(Rhizoma Zingiberis), guizhi(Cassia Twig), etc). 10 days as one course of treatment. 2～6 courses of treatment continually. Results showed that 27 cases were cured, 10 cases had significant effect , 7 cases improved,2 cases were invalid^[33]。②98 cases were treated with a prescription for enema (Wumei(Fructus Mume), xixin(Asarum), chuanduan(radix dipsaci), huanglian (Coptidis Rhizoma), Danggui(angelica sinensis), fuzi((Radix Aconite Lateralis Preparata), guizhi(Cassia Twig), zhixiangfu (Nutgrass Galingale Rhizome),etc). 7 days as one course of treatment. 3 courses of treatment continually. Results showed that 66 cases were cured,accounting for67.3%；29 cases had effect , accounting for30%；3 cases were invalid, accounting for 2.7% . The overall effective rate was 97.3%.^[34]。

29. Metrorrhagia and metrostaxis：15 cases were treated with a prescription (Wumei (Mumeplant Blossom or Fruit), xixin(Asarum), gangjiang(Rhizoma Zingiberis), huanglian(Coptidis Rhizoma), huangbo(cortex phellodendri),guizhi(Cassia Twig) ,chuanjiao(pepper),fuzi(Radix Aconite Lateralis Preparata) , etc). Results showed that 10 cases were cured, 4 cases had effect , 1 cases were invalid. The time taking drugs last from 5 days to 20 days^[35]。

30. Threatened abortion： 104 cases were treated with a prescription (wumeitan, tusizi(Chinese Dodder Seed), baishao( white Herba Peony), Shengdi(Radix Rehmanniae), Shudi(Radix Rehmanniae), huangbo (cortex phellodendri),gancao(radix glycyrrhizae), etc). Results showed that 91 cases were cured, 4 cases improved, 2 cases were invalid. The overall effective rate was 98.08%，The curative rate was 88.64%^[36]。

31. Chronic heart failure：43 cases were treated with a prescription (hongshen(red ginseng ), danggui (angelica sinensis), gangjiang(Rhizoma Zingiberis), fuzi(Radix Aconite Lateralis Preparata), chuanjiao (pepper),chuanlian(Coptidis Rhizoma),huangbo(cortex phellodendri),etc),combining with western medicine routine treatment. 3 weeks as one course of treatment. Results showed that 21 cases had significant effect, 20 cases had effect, 2 cases were invalid. The overall effective rate was 95.35%^[37]。

32. Cardiovascular neurosis：50 cases were treated with a prescription (Wumei(Fructus Mume), guizhi (Cassia Twig), huangbo(cortex phellodendri), chuanjiao(pepper), xixin(Asarum) , gangjiang (Rhizoma Zingiberis) ,Danggui(angelica sinensis),dangshen(radix codonopsis), fuzi(Radix Aconite Lateralis Preparata)). 14 days as one course of treatment. Results showed that 32 cases had significant effect, 14 cases had effect, and 4 cases were invalid. The overall effective rate was 92%^[38]。

33.Chronic prostatitis：28 cases were treated with a prescription for enema (Wumei(Fructus Mume), huanglian(Coptidis Rhizoma), huangbo(cortex phellodendri), guizhi(Cassia Twig), gangjiang(Rhizoma Zingiberis),shujiao(pepper),dibiechong(Eupolyphaga Steleophaga),etc). 7 days as one course of treatment. Results showed that 7 cases were cured, 12 cases had significant effect, 5 cases improved, 4 cases were invalid. The overall effective rate was 85.71％^[39]。

34. Chronic renal failure：71 cases were treated with a prescription (dangshen(radix codonopsis), danggui (angelica sinensis), Wumei(Fructus Mume), gangjiang(Rhizoma Zingiberis) , huangbo(cortex phellodendri) dahuang (rhubarb) , zhike(Fructus Aurantii)). 1 months as one course of treatment. Results showed that 39 cases had significant effect, accounting for 54.9%；22 cases had effect, accounting for31%；10 cases were invalid, accounting for14.1%.The overall effective rate was 85.9％^[40]。

35 Urinary lithiasis：36 cases were treated with a prescription (Wumei(Fructus Mume), huangbo(cortex phellodendri), huanglian(Coptidis Rhizoma), dangshen(radix codonopsis), fuzi(Radix Aconite Lateralis Preparata), chuanjiao(pepper),Danggui(angelica sinensis),guizhi(Cassia Twig),etc). 10 days as one course of treatment. Results showed that 26 cases were cured, accounting for72.2%；7 cases had effect, accounting for19.4%；3 cases were invalid, accounting for8.3%. The curative rate was 72%,the overall effective rate was 91％^[41]。

36. Dental pulp perisplenitis root：168 cases were treated with compound Wumei(Fructus Mume) powder (Wumei(Fructus Mume), pengsha(borax),bingpian(ornel)). Placed it in root canal for a week. Results showed that the overall effective rate was 80.95%^[42]。

37. Recurrent aphthae：36 cases were treated with a prescription (Wumei(Fructus Mume), fuzi(Radix Aconite Lateralis Preparata), guizhi(Cassia Twig), gangjiang(Rhizoma Zingiberis), huangbo(cortex phellodendri), dangshen(radix codonopsis), huajiao(pepper), Danggui(angelica sinensis), etc). 3 days as one course of treatment. Results showed that 30 cases were cured, 5 cases had effect, 1 cases were invalid .The overall effective rate was 97.12％^[43]。

38. Vocal nodules： ①60 cases were treated with Jisheng Wumei(Fructus Mume) pill. Results showed that 32 cases were cured, accounting for53.3%；23 cases improved, accounting for38.4%； 3cases were invalid, accounting for 8.3%.The overall effective rate was 91.7％^[44]。②105 cases were treated with a prescription (Wumei(Fructus Mume), xuanshen(Radix Scrophulariae), maidong(Dwarf Lilyturf Root Tuber), jiegeng (Platycodon Root), niubangzi(Fructus Arctii), zangqingguo(myrobalan), huangqin (radix scutellariae), yuhudie(Oroxylum indicum), etc). 10 days as one course of treatment. 2 courses of treatment continually. Results showed that 29 cases were cured, accounting for27.6% ；67 cases improved, accounting for 63.8％；9 cases were invalid, accounting for 8.6％.The overall effective rate was 91.4％^[45]。

39. Steroid-dependant asthma：20 cases were treated with a prescription (Wumei(Fructus Mume), fuzi (Radix Aconite Lateralis Preparata), dangshen(radix codonopsis),Danggui(angelica sinensis),guizhi(Cassia Twig), baishao( white Herba Peony),xixin(Asarum),huangqin(radix scutellariae),etc). Results showed that 2 cases were cured, 6 cases had significant effect, 2 cases were invalid .The overall effective rate was 90％, without any toxic and side effect ^[46]。

1. Sores, water toxin and swelling with pain

2. Infantile head boils, lingering and intractable for mang years

3. Helosis

4. Swelling and pain in throat

5. Chronic cough

6. Thirst and scanty fluid due to lung heat in upper energizer

7. Intestinal wind and bloody dysentery

8. Pain of umbilical abdomen and bloody dysentery due to heat-accumulation in intestines and stomach, or toxin-accumulation blood dysentery due to over-dose of medicine with hot property

9. Metrorrhagia and metrostaxis

10. Repeated malaria with more slight symptom and profuse phlegm

[1] Shen Hong-mei, Cheng Tao, Qiao Chuan-zhuo, et al. Antitumor Effect in Vitro and Immuno-Response in Vivo of Fructus Mume. China Journal Of Chinese Materia Medica, 1995,20(6):365-368.

[2] Rhee JK, Woo KJ, Baek BK, et al. Screening of the wormicidal Chinese raw drugs on Clonorchis sinensis. Am J Chin Med. 1981,9(4):277-284.

[3] Ma TS, Roper R. Microchemical investigation of medicinal plants. I. The antitubercular principle in Prunus mume and Schizandra chinensis. Mikrochim Acta,1968,(1):167-181.

[4] Microbiology staff room of Shandong medical college. Effects of 110 chinese herbs on antibacterial. Journal of Shangdong medical college, 1959,8(2):171-173.

[5] Zhang Ying-fu, Qiu Xiao-qing, Tian Zhi-feng, et al. Study of Dark Plum on Contractile Activity of Isolated Bladder Detrusor Muscle of Guinea Pigs. SHANXI JOFTCM, 2000,16(02):43-45.

[6] YANG Dong-yan, MA Yong-ming, TIAN Zhi-feng, et al. Study on Effects of Fructus Mume on Myoelectric Activity of Uterine Smooth Muscle of Unpregnancy and Early pregnancy Rats and Its Action Mechanism. Chinese Traditional Patent Medicine, 2000,22(12):34-36.