This plants contains flavonoid: kaempferol, kaempferol-3-O-β-D-glucopyranoside, kaempferol -3-O-(6′′-D-rhamanopyranosyl)-β-D-glucopyranoside, kaempferol-3-O-β-D-glucopyranoside, quercetin-3-O-(2-O-glucopyranoside)-β-D-glucopyranoside^[1], quercetin^[2，11], quercetin-3-O-12-O-(6-O-E-sinapoyl)-β-D-glucopyranosyl-β-D-glucopyranoside, kaempferol-3-O-[2-O-(6-O-E-feruloy1)]-β-D-glucopyranosyl-β-D-galactopyranoside, quercetin-3-O-[2-O-(6-O-E-feruloy1)-β-glucopyranosyl]-β-D-glucopyranoside, quercetin-3-O-sambubioside^[2].

volatile oil: hexadecanoic acid, linoleic acid, 9-octadecenoic acid, borneol)，6,10,14- trimethyl -2-pentadecanonitrile，4- vinyl -2-methoxyphenol^[3];

anthraquinones: 2-methyl-3-hydroxyanthraquinone, 2-methyl-3-methoxyanthraquinone, 2-methyl-3-hydroxy-4-methoxyanthraquinone)，2,3-dimethoxy-6- methylanthraquinone ^[4,6];

terpenoids: E-6-O-p-coumaroyl scandoside methyl ester，Z-6-O-p-coumaroyl scandoside methyl ester，scandoside methyl ester，Z-6-O-feruloyl scandoside methyl ester，E-6-O-feruloyl scandoside methyl ester，Z-6-O-p-methoxycinnamoyl scandoside methyl ester，E-6-O-p-methoxycinnamoyl scandoside methyl ester, scandoside, asperulosidic acid, deacetylasperulosidic acid, geniposidic
acid^[4], asperuloside^[4，8], ursolic acid, oleanolic acid^[4,5], scandoside, scandoside methyl ester, 6-O-p-hydroxycinnamoyl scandoside methyl ester, 6-O-p-methoxycinnamoyl scandoside methyl ester, 6-O-feruloyl scandoside methyl ester^[8];

organic acid: 4,4′-dihydroxy-α-truxillic acid^[4,5], p-coumaric acid^[4];

sterol: stigmasterol, β-sitosterol, β-sitosterol-β-D-glucoside^[6], stigmasta-5,22-diene-3β,7α-diol, stigmasta-5,22-diene-3β,7β-diol^[7], daucosterol^[11];

sugar: glucose, galactose, arabinose^[9，10].

Other: scopoletin^[11], alkaloid, coumarins ^[4];

Baihuashesecao (Oldenlandia diffusa)

1 infectious diseases: baihuashesecao injection which producted byyujiang pharmaceutical factory to treat 304 cases of infectious diseases , withthe baihuashesecao injection 4ml,twice a day,intramuscular，1 week as a course oftreatment. Result：128 cases were cured after take the medicine 1 week,90 cases wereexcellent,64 cases were improved, 22 cases were invalid, the total effectiverate was 92.76% ^[1].

2. Middle-advanced stageesophageal: 24-60ml Oldenlandia diffusa injection(including crude 24-60g ) to join 5% glucose(hydrothorax or ascites with 10% glucose)250ml(with 24ml)-500ml(above 26ml) intravenousdrip. the drug dose: first day 24ml, second day 36ml, third day 48ml, forth day60ml, later maintain in 60ml/day, 40 to 60 drops every min, A serious heart patientswith caution, fivedays for a general treatment, Eachcourse withdrawal between 2 days, Every four treatment discontinuation between 2weeks, After four timesin four treatment after a course evaluation results. 106 cases were treated. Result: The complete remission 19 cases(17.9%), 43 patientsease (40.6%), Stable27 ease (25.5%), Progress of17 cases (16%) ^[2].

3 Primary liver cancer: baihuashesecao injection (Guizhou qi-kaipharmaceutical Co., LTD, approvedby the enterprise Z20025716) 4ml/time, three times per day, 4 weeks for a period of treatment, act 2 treatment. Results: after treatment,the effective rate (CR + PR) is 17.5%, stable rate (CR + PR + NC) is 62.5%,half year survival rate was 60.0%, 1 year survival rate was 27.5% ^[3].

4. Acute appendicitis: fresh baihuashesecao(all the grass) 30-120 g (dried by half), water decoction. In order to quicklycontrol the symptoms, the first dose is larger than the next and the first dayneed 4 agents. The heavier such as acute appendicitis with peritonitis, thefirst dose is 120g.Then half of the first dose next, from the second day take 2-3 agents every day. The lighter, such as unsophisticated appendicitis, thefirst dose is 60-90g, and half of the first dose next, first day take 4 agents,the second day take 2-3 agents a day. Every agent decoction 1 time. Results:The symptoms disappear after 3-4 days. Temperature returned to normal first,then blood, and tenderness disappear latest. 187 cases cured in the 211patients, accounting for 88.6%, basic cure in 15 patients, accounting for 7.1%,invalid transit operation 9 cases, accounting for 4.3%. Interim surgerypatients were for poison dyke type, intraoperative found diffuse peritonitis byappendix gangrene or perforated, no death. Through the clinical practiceobservation, acute simple appendicitis, purulent appendicitis, acuteappendicitis and limitations and light symptoms appendix abscess, use baihuashesecao onlycan cure ^[4].

Taste: bitter, sweet; property: cold; belong to heart, lung, liver and large intestine channels.

Function: clearing away the heat-evil and removing toxic agents, eliminating wetness

 Syndromes to be treated: cough due to lung fever, swelling and sore throat, jaundice, dysentery, enteritis, appendicitis, stranguria caused by heat-evil, edema, swollen boils, snake bites, cancer

Oral administration: decoction, 15～30g, large doses can be used to 60g;

Topical application: in right amount, smashed and smear on the skin.

Forbid to be used in pregnant.

1.       Sore throat, conjunctivitis

2.       Pulmonary abscess, pneumonia

3.       Gastroduodenal ulcer, chronic gastritis

4.       Gastric cancer, Esophageal cancer, rectal cancer

5.       The acute and chronic cholecystitis, cholelithiasis

6.       Rectum reaction of radiotherapy after intestinal cancer, cervical carcinoma and other abdominal cancer

7.       Appendicitis

8.       Urinary system infection

9.       Traumatic injury

10.   carbuncle and furuncle

11.   Venomous snake bite

12.   The acute and chronic pelvic inflammation

13.   Cervical erosion

14.   Acute infantile convulsions

[1]YanGuiLan. Baihuashesecao injection treatment of infectious diseases 304 cases.Practical TCM internal medicine journal, 1998, 12(2):19

[2]TangLiMing, WangJinHua, ZhouHongJin. The clinical observe of intravenous dripbaihuashesecao injection treat middle-late esophageal cancer in 106 cases.Hainan medicine, 2003, 14(2):75.

[3]LiuJunBao, YaoZhiWei. The clinical effective of baihuashesecao injection on primaryliver cancer. Medical forum magazine, 2004 (15):37.

[4] yaoyuxiu.Thetreatment of 211 cases acute appendicitis with baihuashesecao. Chinese journalof integrated traditional Chinese and western medicine, 1983 (5) : 284.
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