1. Antibacterial, anti-virus: the bulbifera flooding agent (1:3) in 20% to 40% of its concentration within the yellow Trichophyton, concentric Trichophyton rubrum, Xu Lan Huang, Audubon Ang Bacillus dermatophytes. Small spore ringworm of the rust-colored, wool-like Bacillus dermatophytes, plaster-like Bacillus dermatophytes, groin epidermis dermatophytes, red epidermis dermatophytes, star slave card Jundeng skin fungi have different degrees of inhibition [1] . Isolated alkaloids dihydro yam base in the 0.1% concentration can inhibit the growth of a variety of plant pathogenic fungi [2]. Bulbifera alcohol extract at 0. 017 ~ 0. 034 mg / ml can not only destroy the DNA viruses, can inhibit the transcription of RNA viruses, inactivated virus or drug control cells are still able to continue to divide ,the passage shows bulbifera is non-toxic and effective, the bulbifera flooding agent for all types of virus have no inhibitory effect [7]. Decoction of Dioscorea bulbifera have a better inhibitory effect on the golden grape coccus, E. coli, Candida albicans, the inhibition, the inhibitory effect of the bulbifera organic solvent extract is better than a decoction of Dioscorea.

2. Anti-goiter: Huangyaozi, 2% to 5% of the amount of mixed servers compound feed wait then wait materials of iodine deficiency induced goiter in rats have a therapeutic effect, potassium thiocyanate (0.1% aqueous solution of drinks) mild goiter caused. Bulbifera anti-goiter effect may be more likely due to its iodine is excessive,per one kilogram bulbifera iodine content of 14.3mg [3].

3. Weakened the role of the heart: 20% bulbifera water decoction or alcohol dip matter liquid water to 1:500 concentration of 0.1 ml enable the isolated frog heart contraction reduced, heart rate dropped, ventricular and atrial dilatation in relaxation; 1:50 concentration of 0.1mL, enable the isolated frog heart was immediately suppressed ventricular arrest, the atrium and sinus are still beating, but within 15 minutes to stop activities in the diastolic state. 20% bulbifera water decoction or alcohol soaked material liquid water was weakened by the subcutaneous or intravenous injection, allows the reign of frog cardiac contractility weakened, heart rate dropped, ventricular and atrial dilatation in relaxation and contraction of the incomplete state. When the vein of alcohol Baptist liquid water up to 1 ml, the ventricular contraction is immediately reduced, and stopped beating within 27 minutes. The bulbifera direct inhibition of myocardial effects of alcohol dip matter of liquid water is better than the water decoction of strong inhibition of [4].

4. Role of smooth muscle: 20% bulbifera water decoction or alcohol soaked material water solution 2 ml, inhibited the rabbit intestinal smooth muscle; excitatory effects on the rabbit and guinea pig isolated pregnant uterus, the emergence of rhythm contraction and tonic contraction [4].

5. Anti-tumor: the bulbifera alcohol (extract) 50 mg/kg and 100 mg/kg dose on the inhibition rate of the mouse hepatoma H22 were respectively 19.5%and 36.3%. Murine sarcoma S180 tumor inhibition rate were respectively 24.3% and 31.6%; bulbifera ethanol extract treatment of mice with ascites tumor(EAC), can significantly prolong the survival of the number of days, when the dose of 100 mg / kg, allows mice extend the life of the rate of 74.1% [14]. Bulbifera factors A, B, C and diosgenin will have great anti-tumor effect, especially on the thyroid tumors have a unique effect.The bulbifera oil on cervical cancer in mice (U14), murine leukemia 615 have a certain degree of inhibition [7]. Bulbifera petroleum ether, ether extract, ethanol extract, water extract inhibited the tumor-bearing mice, tumor growth, prolong survival, compared to petroleum ether and the ether extract with the control group were significantly different (P<0.01 ); in vitro tumor inhibition experiments, the ether extract of liver cancer six tumor inhibition rate compared with the other three components have significant differences (P <0.01), ethanol extract, water extract on bladder hazy cancer giant-cell lung cancer tumor inhibition rate compared with the other three components were significantly different (P<0.01) prompted the antitumor effect of different extracts of Dioscorea bulbifera is different, so choose a different extraction methods [10] when clinical bulbifera treat various tumors. when the bulbifera alcohol extract certain degree of inhibition of S180 (sarcoma) of 50 mg/kg, the mice tumor weight was significantly lower than the control group and the high-dose group, significant differences (P<0.05)[11]. Bulbifera compatibility Angelica by lower expression of P-gp and increase tumor resistance to role of xanthate child's [14], its petroleum ether extract material has a significant anti-tumor activity, and antitumor effect relevant to direct cell role [15].

6. Anti-inflammatory: the mouse ear inflammation caused by the bulbifera methanol extract of para-xylene, egg white and carrageenan-induced rat paw edema and granuloma in rats significantly inhibited and anti-inflammatory effect of the existence of a certain dose-effect relationship[12]. Bulbifera B prime one of the active ingredient of the anti-inflammatory [13].

7. Others: a Polysaccharide isolated from Dioscorea bulbifera and other Dioscoreaceae plant polysaccharides reduce the role of blood glucose [5].

8. Toxicity: mice fed with 200% bulbifera water decoction of the median lethal dose (LD 50) is 79.98g (crude drug) per kilogram. Sub-acute toxicity tests showed that mice fed with water decoction of Dioscorea bulbifera 19.9 grams per day (crude drugs) per kg for 14 consecutive days or 21 days, visible pathological observation of liver tissue was significantly impaired [6], the mechanism may be induced by P 450enzymes CYP1A2 and CYP2E1mRNA expression, inhibition of mRNA expression of the antagonistic toxic to the liver [16] after Angelica compatible bulbifera. Renal tissue in 21 days of the high-dose group appeared a certain degree of damage [6].

Malignant tumor:Huangdu extract as treatment group for malignant tumor,results: the treatment group total effective rate was 56.7%, 16.1% in controlgroup, with significant difference (P < 0.05); Treatment group of adversereaction was 1.7%, and 32.2% in control group, has the extremely significantdifference (P < 0.01) ^[1]. 

1.Smallpox in eyes

2.Prevention for relapse of carbuncle on the back which had been with pus out

3.Sprain

4.Venomous snake bite

5.Unstopped epistaxis 

6.Unstopped bleeding on tongue

7.Swollen tongue

8.Hemoptysis

9.Cough and asthma

10.Sore and swollen throat induced by toxic heat

11.Acute laryngeal infection with sore throat, swollen chin, phlegm in chest, and dysphagia

12.Rectal cancer, cardiac cancer, lovwer esophageal cancer

13.Diarrhea

14.Hyperthyroidism

15.Scrofula

16.Orchitis

17.Infantile sore and swollen throat

18.Infantile hernia

1. Jinpu Capsule: artificialcow-bezoare, honeysuckle flower, dandelion herb, barbated skullcup herb,hedyotis, flavescent sophora root, all-grass of black nightshade, pangolinscales(roasting), zedoary, rhubarb, frankincense(prepared), myrrh(prepared),corydalis tuber(prepared), safflower, centipede, appendiculate cremastrapseudobulb, pearl, air potato, ginger processed pinellia, toad venom, dangshen,scutellaria root, root and vine of manyprickle acanthopanax, amomum fruit.

Chemical Composition:

[1] Gao Huiyuan, Sui Anli, Chen Yihong, Et Al. Chemical Constituents Of Dioscorea Bulbifera L.. Journal Of Shenyang Pharmaceutical University,2003,20(3):178

[2] Yellow Kaiyi Dongsong, Zhang, Gao Huiyuan, Et Al. The Chemical Constituents Of Dioscorea Bulbifera L. Journal Of Shenyang Pharmaceutical University,2007,24(3):145

[3] Gao Huiyuan, Wu Lijun, Yin Kai, Et Al. Studies On The Chemical Constituents Of Dioscorea Bulbifera L. Journal Of Shenyang Pharmaceutical University,2001,18(6):414

[4] Li Shisheng, Deng Jingzhen, Zhao Shouxun . The Dioscorea Bulbifera Tuber Steroidal Components Of Plant Resources And Environment,1999,8(2):61

[5]Zhengs, Guozhen, ST, Et A1.Three Newapianen Lactones Fromdioscoreabulbiferal.Indian Journal Of Chemistry, Section B:Organic Chemistryincluding Medicinalchemistry,2003,42B (4):946

[6] Fu Hongzheng, Lin Wen Han, Gao Zhi Word, Such As.2DNMR Research New FS Two Terpenoids Structure. Journal Of Electronics,2002,19(1):49

[7] State Administration Of Traditional Chinese Materia Medica Editorial Board."" Chinese Materia Medica. Shanghai: Shanghai Science And Technology Press,1999,22:224( Total7278).

[8]Huiyg, Lijw.Masanori K Seven Glycosides Fromdioscorebulbifera L.Naturalmedicines,2003,57(5):200

[9] Tan Xingqi, Ruan Jinlan, Chen Haisheng, Et Al. Anti-Inflammatory Constituents Of Dioscorea Bulbifera L. Research. Journal Of Second Military Medical University,2003,24(6):677

Pharmacological Effect:

[1]Cao Renlie .Journal Of Department Of Dermatology,1957, (4):286

[2]Addeyea, Etal..CA.1990112:33221g.

[3] Physiology Research Group Of Endocrine Research Group, The Shandong Medical Journal,1961, (1):11

[4] Pharmacological Research Group, The Shandong Medical Journal,1959, (3):87

[5]Hiroehi H, Etal, CA,1986105:120732y.

[6]Song Chongshun.Chinese Medicine Bulletin,1983.8(4):34

[7] Lin Houwen, Zhang Gang, Zhao Hongbin, Et Al. Research Progress Of Dioscorea Bulbifera L. Chinese Herbal Medicine,2002,33(2):175

[8] Hu Junfeng, Ma Yongde, Song Yue. Decoction Of Dioscorea Bulbifera L Anti Bacterial Effect Of Heilongjiang Medicine,2007,20(1):13

[9] State Chinese Medicine Administration Bureau" Chinese Materia Medica" Editorial Board . Chinese Materia Medica, Eighth Books. Shanghai: Shanghai Science And Technology Press,1999:224.

[10] Li Jianheng,Zhang Xinghong, Chi Honghua. Dioscorea Bulbifera By Different Extraction Method Research On Anti-Tumor Effect. Hebei Medical Journal,17,2000, (2):5

[11] Chen Xiaoli, Wu Shaohua, Zhao Jianbin . The Dioscorea Bulbifera Alcohol Extract On Mice Transplanted Tumor Suppressive Effect. Journal Of The Fourth Military Medical University,1998;19(3):354

[12] Li Wan, Ruan Jinlan, Huang Yubin. Experimental Study On The Anti-Inflammatory Effect Of Dioscorea Bulbifera L. Practical Journal Of Medicine,,1996,9(4):20

[13] Tan Xingqi, Ruan Jinlan, Chen Haisheng, Et Al. Anti-Inflammatory Constituents Of Dioscorea Bulbifera L. Research. Journal Of Second Military Medical University,2003,677,24(6)

[14] Qing Suo, Liran, Cui, Liu Shumin, Et Al. Of Dioscorea Bulbifera L And Compatibility Of Angelica After Anti Tumor Action Of The Medicated Serum Of Chinese Medicine Science And Technology,2008,15(2):113

[15],Yu Zelan Liu Xinrong, Michael, Mcculloch, Etc. Of Dioscorea Bulbifera L Antineoplastic Active Component Selection And Effect Analysis. Chinese Journal Of Medicine,2004,29(6):563

[16] Liu Shumin, Zhang Lin, Li Ying, Et Al. Of Dioscorea Bulbifera L And Angelica Sinensis Compatibility On Rat Liver CYP1A2, CYP2E1gene Mrna Expression Of Pharmacology And Clinic Of Chinese Traditional Medicine,2006,22(3):97

Clinical Trials:

[1] Li Jianheng, Pan Ying, In Bingqi. Elimination Of Different Solvent Extracts In Treatment Of Malignant Tumors To Compare And Research The Clinical Effect. Based Medicine,2002,19(4):1

Toxicology:

[1] Song Chongshun, And So On . Chinese Bulletin,1983,8(4):34

[2] Hu Zhenying, Shi Yanbin, Luo Yonghong, Et Al. Of Dioscorea Bulbifera L In Vitro Bacteriostatic And Toxicity Test Animal Medical Journal,2005,26(10):86-88

[3] Song Chongshun, Liu Xianfang, Du Yu Tang, Etc. Of Dioscorea Bulbifera L On Hepatic And Renal Toxicity Of Preliminary Experiments . Medicine Bulletin,1983,8(4):34-36

[4] Su Li, Jianhua Zhu, Chen Li Po, And So On. Subacute Intoxication By Dioscorea Experimental Pathological Study On Forensic Medicine,2003,19(2):81-83