1 Antiviral agents,Bacteriostasisand Antipyreticeffect: Cayratia japonica gagnep herb had obvious anti-bacteria effects onStaphylocossus aureus, Staphylococcus epidermidis, Colibacillus, Bacilluspyocganeus, Bacillus proteus, Typhoid bacillus and Dysentery bacillus [1]. Theoil showed pronounced antiviral activities against influenza virus A, in vivoand herpes simplex virus 1 (HSV-1) in vitro. The inhibitory effect of the oilon replication of HSV-1 in Hela cells was comparable to that of acyclovir(ACV). Cayratia japonica gagnep herb has obvious effect on purulent infection[2-4].

2 Anti-inflammatory effects:Cayratia japonica gagnep herb had significant anti-inflammatory effects [5]. Cayratiajaponica gagnep herb has obvious effect on purulent infection [6].

3 Coagulantfunction: Rats fed Cayratia japonica gagnep herbdecoction alcohol extract liquid 25g/kg and Cayratia japonica gagnepherb alcohol extract 25g/kg for 14 days, Cayratiajaponica gagnep herb alcohol extracts can thrombuslength and thrombosis dry weight decreased significantly, significantly reduce adhesionrate of platelet [7]. Cayratia japonica gagnep herb can significantly inhibit adenosine diphosphate,collagen-induced platelet aggregation, Moreover, it also significantlyinhibited the kaolin partial thromboplastin time and thrombin time [8].

4 Immunological function: Cayratia japonica gagnep herb could decrease the weight of thymus and spleen inim-munosuppresive mice, and strengthen phagocytosis of reticuloendothelialsystem in normal and im-munosuppresive mice. At the same time, Cayratiajaponica gagnep herb could improve lymphocytetransformation and had noobvious effects on IL-2 activity in immunosuppresive mice and increased cellularimmunity function [7,9].

5 Toxicity: Cayratia japonica gagnep herb decoction alcohol liquidis intraperitoneal injected to mice, resulting in the median lethal dose (LD50)51.12g/kg, that of Cayratia japonica gagnep herb alcohol extract is the LD50 for 102.8g/kg[7].

1. Herpes zoster: 80 cases of patients were treated with Wulianmei and borneol. Results showed that all patients were cure. The treatment was proceeding as follow: the affect area was cleaned by tea water fist, then the medicine was applied on it, four times a day^[1].

2. Acute mastitis: 101 cases of patients were treated with Neixiao powder, one prescription for each day, taken decoction twice a day, 2~5 prescription as one course of treatment. During the treatment, Wulianmei cream were external applied on the affect area. Results: 43 cases with symptoms of high fever, shivering and white blood cell count increase were cure; 21 cases with symptoms of nipple fissre and mild discharged were cure after one course of treatment, 18 cases were cure after two course of treatments; three cases with symptoms of breast masses were cure after one course of treatment, ten cases were cure after two course of treatments. The overall cure rate was 99%^[2].

3. Acute sprain and dampen: Fresh herbs were mash up with salt and applied on the affect area. If symptoms were not disappeared and no allergic effect was occurred after 7h, herbs were reapplied till symptoms were disappeared. 103 cases of patients were treated with this method, results showed that 75 cases' symptoms were disappeared within 7h, ten cases needed the external application twice, 12 cases need three times and six cases occurred the allergic effect^[3].

4. the 4^th term pressure sore: Three cases of patients were treated with Wulianmei and Saimeian powder. Results showed that patient's purulent exudate of wound were reduced after one day treatment, granulation tissue appeared on the wound after three days, granulation tissue were filled with the surface of wound after 7~10 days . All cases were cured after 2~4 month^[4].

5. Acute parotitis: 69 cases of patients were treated with Wulianmei decoction. Results showed that all cases were cured. twenty cases were cured after given on prescription, and ten cases cured after two prescription, 39 cases cured after 6 prescription^[5].

1. All kinds of pyogenic infections, ulcer and carbuncles, effusion of the back, mammary abscess, excessive heat in intestines, malignant sores at the beginning period

2. Heat and swelling of the nape, also called toad head plague

3. Mammitis

4. Ecthyma

5. Herpes zoster

6. Adenolymphitis

7. Pharyngitis

8. Rheumatoid arthritis pain

9. Hemoptysis due to pulmonary overstrain

Pharmacology  Actions:
[1] Fu-yu Yao, Experimental Observation of the Anti-bacteria Effects of Cayratia japonica Gagnep, Lishizhen Medicine and Materia Medica research, 2000,11 (1): 53．

[2] You-yuan Tang, Bing-wen Liang, Pharmacological studies of Chinese herbal medicine Cayratia japonica (Preliminary Report) black grabbing berries injection inhibition of influenza virus, Chinese medicine informed, 1982, 7 (2): 37．

[3] Li Luo, Shi-xuan Liao, Hua-qing Liang et al., Constituents and Anti-virus Activity of Essential Oil from Cayratia japonica, Acad J Sec Mil Med Univ., 1992, 13 (2): 169． 

[4] You-yuan Tang, Antibacterial antipyretic effects of the pharmacological studies of herbal medicine black pentaphyllum II Cayratia japonica injection, Chinese medicine informed, 1985, 10 (8):3 78．

[5] Yue-fang Gu, Hai-gui Zhang, Dao-xiu Shen, Cayratia japonica anti-inflammatory effects of the study (presentation), Chinese medicine informed, 1988, 13 (9): 558.

[6] Cui-e Deng, Jian-rong Lin, Jie-wen Zhu et al., Effect of Cayratia japonica Gagnep on Purulent Infection, Lishizhen Medicine and Materia Medica research, 2007, 18 (4): 865.

[7] Yue-fang Gu, Hai-gui Zhang, Cayratia japonica on blood coagulation and immune function, National Medical Journal of China, 1991,13(4):26．

[8] Yue-fang Gu, Hai-gui Zhang, Dao-xiu Shen, the pentaphyllum clotting effect, Pharmacology and Clinics of Chinese Materia Medica, 1989, 5 (1): 46．

[9] Dao-xiu Shen, Chinese Pharmacologist, 1989, 6 (2): 8．

Clinical trial:

[1]Hu Fayu. Japanese Cayratia Herb and borneol Treat herpes zoster in 80 cases. Hubei Journal of Traditional Chinese Medicine.1981,(3):39

[2]Yu Suijuan . Combining Neixiao powder and External Application Japanese Cayratia Herb paste in treatment of acute mastitis in 101 cases. Journal of Nanjing University of Traditional Chinese Medicine.1995,11(5):60

[3]Gong Min,Xia Lili. Japanese Cayratia Herb in treatment of Acute Torsional Contusion. Zhejiang Journal of Traditional Chinese Medicine.1997,(9):423

[4]Zhou Xiaorong. Japanese Cayratia Herb and Saimeian powder in domestic treatment of 用于 Pressure ulcer of the forth stage. Nursing and Rehabilitation Journal.2006,5(2):150

[5]Chen Longyao. The Solution of Japanese Cayratia Herb in treatment of Acute mumps. New Journal of Traditional Chinese Medicine.1978,(1):16