Orbicular Snailseed Root - China and Thailand medicinal plants professional database

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[English Name]	Orbicular Snailseed Root
[Chinese Name]	木防己
[Pinying Name]	Mufangji
[Latin Name]	Cocculi Orbiculati Radix
[Genera]	Menispermaceae
[Efficacy]	qufengshiyao
[Pictures]	Plant picture	Drug picture

[Alias]
[Source]
[Plant morphology]
[Distribution]
[Gathering and processing]
[Characteristics]
[Ecology]	It grows beside road of hillside or in open forest.
[Chemical composition]
[Pharmacological activities]	1. Antiarrythmic: Mufangchine show antagonism arrhythmia activity induced by chloroform, barium chloride and so on through adjust central and direct effect on cardiac muscle[1]. Dimethyltrilobine iodide(DTI) show similar action through prolong muscle action potential plateau phase and atrium muscles refractory period[2]. 2. Flaccidity: DTI show flaccidity activity on rat, rabbit and cat through compete N₂acceptor acetylcholine[3-5]. 3. Lowering Blood Pressure: Mufangchine show dose-dependent lowering blood pressure activity on cat[6]. DTI has dose-dependent lowering blood pressure activity through ganglionic blocking action and inhibit renin angiotensin systems[3,5,7,8]. 4.Other Effect: Methanolic extract show antibiosis effect on crops pathogenic bacteri[9]. Mufangchine still has anesthesia action[10]. Polysaccharides show scavenging free radicals activity[11]. 5. Physiological Disposition: Mufangchine fitted to a two compartment open model after single intravenous dosing, t_1/2β was 0.95~1.54 h[12].
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[Medical and other Uses]
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[Traditional usage]
[Toxicological studies]
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[References]	Pharmacologic Actions: [1] Zhou Junjie, Zhao Gengsheng. Chinese Journal of Pharmacology and Toxicology, 1988,2(2):89. [2] Ming Zhen, Zhao Gengsheng. Acta Pharmaceutica Sinica, 1984,19(1):12. [3] Liang Yingbin, Wang Lifang, Zhang Liying. Shaanxi Medical Journal, 1984,2(5):55. [4] Cao Yongxiao, Che Xiping, Yuang Bingxiang. Acta Pharmaceutica Sinica, 1986,21(10):781. [5] Yongxiao, Che Xiping. Acta Pharmaceutica Sinica, 1987,22(6):462. [6] Tan Jianquan, Chu Zhengxu, Qiu Chengzhi, et al. Academic Journal of Second Military Medical University, 1983,4(3):171. [7] Liu Junbao, Che Xiping. Acta Pharmaceutica Sinica, 1984,19(5):338. [8] Liu Junbao, Che Xiping. Acta Pharmaceutica Sinica, 1984,19(10):790. [9] Yang Cheng. Southern Hornticulture, 2009,20(1):5. [10] 1976:173. The Compilation of Chinese Herbal Medicine Drafting Group. The Compilation of Chinese Herbal Medicine(Vol 1). Beijing: People’s Medical Publishing House, 1976: 173. [11] Yang Haidong, Chen Yanmei, Liu Shufang, et al. Acta Neuropharmacologica, 2005,22(2):5. [12] Xu Keyi, Tan Jianquan, Ye Xiaowei, et al. Acta Pharmaceutica Sinica, 1987,22(9):704.