1. Lower blood sugar: Mulberry leaves and ecdysterone had hypoglycemic effect on alloxan induced diabetic in rats or hyperglycemia in mice caused by Epinephrine, pancreatic glucagon and insulin resistance serum [1, 2]. Ecdysterone promoted glucose into glycogen [2]. Some people think that mulberry leaves contain certain amino acids to stimulate insulin secretion, which was the insulin secretion and release adjustment factor [3].

2. Antibacterial: 1g/mL fresh mulberry leaf decoction had a strong antibacterial effect on Staphylococcus aureus, beta-hemolytic streptococcus, diphtheria bacillus and Bacillus anthracis and also had a certain antibacterial effect on E. coli, Salmonella typhi, Shigella and Pseudomonas aeruginosa [4]. High concentrations of mulberry leaves water decoction solution in vitro can canfront Leptospira [5].

3. Others: Ecdysone can promote cell growth, stimulate the dermal cell division, resulting in the newborn epidermis and to promote insect molting. For humans, ecdysone can promote protein synthesis, to rid the body of cholesterol, lower blood lipids [6]. Phytoestrogens of mulberry leaf ethanol extract fed mice can lower the growth speed [7].

4. Toxicity: Injection of 10% mulberry leaves injection to rabbit quadriceps or dropped in eye onjunctiva, no local stimulation effect detected. Guinea pig allergic reaction test was negative and in vitro tests on sheep red blood cells found no hemolytic reaction [8]. Safe injection dosage, equivalent to 250 times of the human, was given to mice once. In the subacute toxicity tests, intraperitoneal injection of mulberry leaves injection of 60 times of the human dosage for 21 days had no damage to internal organs. If given a larger dose, it can cause degeneration and hemorrhagic damage to liver, kidney and lung [8].

Chemical composition:

[1] state Chinese medicine administration bureau " Chinese Materia Medica " editorial board. Chinese materia medica. Shanghai: Shanghai science and Technology Press, 1999,5:520 ( total 1095).

[2] Zhou Yonghong, Li Weiguang, Wang Lisheng, etc.. Chemical constituents of volatile oil from leaves of GC-MS analysis. Guangxi science, 2005,12 ( 1): 50

[3] state Chinese medicine administration bureau " Chinese Materia Medica " editorial board. Chinese materia medica. Shanghai: Shanghai science and Technology Press, 1999,5:528 ( total 1100).

[4]Asano N. Sugars with Nitrogen in the RingIsolated in the Leaves of Morns Bombycis. Carbohydr Res, 1994:235.

Pharmacological effect:

[1]Sharaf AA, etal.C A, 1963,60:4650g.

[2]Yoshida T, et al.Biochem Pharmacol, 1971,20 ( 12): 3263

[3]Liu Yaguang . From the perspective of molecular biology of medicine effect principle. New Chinese medicine, 1979, ( 01): 50

[4] Hunan Lingling area health and epidemic prevention station. 561 kinds of antibacterial effect of screening report. Hunan medical journal, 1974, ( 4): 50

[5] Xuzhou Medical College. The new medical information, 1971, ( 1): 27

[6] Beijing medical school, etc.. Chemical composition of Chinese herb. First edition . Beijing: People's Medical Publishing House, 1980:420.

[7]Saxena S K.C A, 1979,91:69467d.

[8] Shandong province Linyi County Health Bureau, health and epidemic prevention station, and so on. Newsletter of Chinese herbal medicine, 1972, ( 6): 334

Clinical trials:

[1] Luo Chunmiao, Luo Miao, Yang Xining, etc.. Hibiscus leaves Daolan topical treatment of postpartum breast distending pain clinical observation. Guangxi Journal of traditional Chinese medicine, 2007,30 ( 6): 17

[2] Cui Ping, Hou Qiang, Liu Guangfeng, etc.. Compound of mulberry leaf on pneumoconiosis disease curative effect observation. Chinese Journal of industrial medicine, 2007,20 ( 4): 225

Toxicology:

[1] Shandong province Linyi County Health Bureau, health and epidemic prevention station, and so on. Newsletter of Chinese herbal medicine, 1972, ( 6): 334