| [English Name] | Malaytea Scurfpea Fruit | |
| [Chinese Name] | 补骨脂 | |
| [Pinying Name] | Buguzhi | |
| [Latin Name] | Psoraleae Fructus | |
| [Genera] | Leguminosae | |
| [Efficacy] | buyao | |
| [Pictures] | Plant picture | Drug picture |
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| [Plant morphology] | ||
| [Distribution] | ||
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| [Characteristics] | ||
| [Ecology] | It prefers warm and moist climate,is suitable for the envoroment flat ,exposed to the sun and with enough sunshine.There is no strict damand of soil,can be planted in ordinary soil,but sandy soil with rich humus is best,the worse is clayed soil.Seed emerges about seven to ten days in the temperature |
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| [Chemical composition] | This plant contains psoralen, isopsorasen (angelicin), xanthotoxin (8-methoxypsoralen), psoralidin, isopsoralidin, bakuchicin, psoralidin 2′,3′-oxide, corylidin, bavacoumestan A, bavacoumestan B, sophoracoumestanA[1], astragalin, bavachin (corylifolin, isobavachin, bavachinin, furan(2′′,3′′,7,6)-4′hydroxy flavanone, corylifolinin (isobavachalcone, bavachalcone, bavachromene, neobavachalcone, isoneobavachalcone, bakuchalcone, bavachromanol)[1], corylin, neobavaisoflavone, corylinal, psoralenol)[1,2,5], bakuchiol, corylifonol, isocorylifonol, p-hydroxy-benzoic acid, bavachromene, pinitol, daidzin, uracil, stigmasterol, β-sitosterol-D-glucoside, triacontane, triglyceride, diglyceride, monoglyceride, wax ester, hydrocarbon. It also contains trypsininhibitor; elements: K, Mn, Ca, Fe, Cu, Zn, As, Sb, Rb, Sr[1,3,4], palmitic acid, oleic acid, linoleic acid, stearic acid, linolenic acid)和二十四酸(lignoceric acid)[1], trans-2-caryophyllene, caryophyllene oxide [6]. | |
| [Pharmacological activities] |
1.the role of the cardiovascular system: effects of corylifolinin can significantly expand coronary arteries, increase coronary blood flow and can counteract pituitrin on the contraction of the coronary arteries, but is unlikely to impact on the total peripheral vascular resistance [1]. 2.anti-tumor: effects of corylifolinin can inhibit murine Sarcoma S180 [1]. 3.photosensitivity: the rough preparation of corylifolinin can promote photosensitization. After oral or topical, it can make the skin be sensitive to ultraviolet light, prone to pigmentation. If severe, redness and blisters can occur [2]. 4.anti-early pregnancy and estrogen-like effects: effects of corylifolinin and bakuchiol have a significant role in anti-implantation of mouse. The dry powder of Malaytea Scurfpea Fruit, cut into the ovary of a normal female adult rats, can increase the angle of the vaginal hornification [3]. The study on the non-saponin constituents of corylifolinin seeds shows that its contraceptive capacity depends on its estrogenic activity [4]. 5.resistance to pathogens: extracts of corylifolinin has inhibition resistant on Staphylococcus and antistaphylococcal penicillins [5]. |
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| [Clinical trial] | 1.Treatment of Senile Osteoporosis: 81patients of senile osteoporosis were treatment throug BuGuZhiTang. Results:after treatment, the value of bone mineral density increased significantly, itwas significant difference on compared with before treatment (P < 0.05). 59patients were powerfully in Pain relief (72.84%), 13 cases were effective(16.05%), 9 cases were failed (11.11%), the total effective rate 88.89%[1].
2. Treatment of femoral Head Necrosis: Effect of BuGuZhiTangJi on Treatmentof femoral Head Necrosis in 30 cases. Results: after treatment, 7 cases wereaffected markedly effective comprehensive, 16 cases were effective , 7 caseswere invalid, the total effective rate was 76.7%. Imaging effect of 10 caseswere markedly improved, 15 cases were effective , 5 patients were invalid, andthe total effective rate were 83.3%[2].
3.Treatment of Warts:(1) Treatment of Viral Warts: BuGuZhi30 g, JiDanZi 30 g, HongHua 15 g, were broken and extracted for a week by 200mL75%alcohol , warts surface was besmear by Drug extract after filtering, 3 times per day, 1 treatmentcourse per 15 days. Results: treatment contagious soft wart were 43 cases, 36cases were cure, accounting for 83.7%,7 patients of improved were 16.3%,32 cases of 39 cases of flatwarts were recovery, accounting for82.1%,7 patients of improved were 17.9%; Acuteness wet warts were 15 cases, 12cases were cure ,accounting for 80%, 3 cases were improve, accounting for 20%;Unusual warts were 51 cases, 43 cases were cure, accounting for 84.3%, 8 cases were improve, accounting for 15.7%; plantarwarts were 16 cases, and 12 cases were cured,accounting for 75%, 4 cases were improved, accounting for 25%[3].(2)Treatment of Common warts, plantar warts: 32 cases of common warts were treated by BuGuZhi ethanol extract, 31 cases were recovery, accountingfor 98.88%, 1 case was improved, accounting for 3.12%; 10 cases were plantarwarts, 8 cases were recovery ,accounting for 80%, 2 cases were improved , accounting for 20%; The totaleffective rate was 100%[4]. 4 Treatmentof psoriasis: BuGuZhi injection, muscle deep injection ,1 time per day , 4 mlper time.one treatment course per 10 times. Results: 800 cases were cure ,125cases were recovery, accounting for 15.6%; 238 cases were positive effect,accounted for 29.8%; 381 cases were improved, accounting for 47.6%, 56 caseswere invalid, accounting for 7%. The total effective rate was 93%[5]. 5.Treatment of alopecia areata:(1) 20cases of alopecia areata were treated by BuGuZhitincture for external use, 15 cases were recovery, 3 cases werepositive effect,one was effective ,one case was invalid [6].(2) 34 cases of alopecia areata weretreated by BuGuZhi tincture forexternal use and combinedwith internal medicine and line MeiHuaZhen, cultivate psychological treatment,22 patients were cure accounting for64.7%; 10 patients were improve accounting for 29.4%; Satisfactory in 2 caseswere invalid, accounting for 5.9%. The total effective rate was 94.1%. it wasnot found to side effects[7].
6. Treatmentof Bronchial Asthma in AcuteAttack: 30 cases of acute attack of bronchial asthma were treated on BuGuZhi Preparations, 20 cases were positive effect (66.7%), 7cases wereeffective (23.3%), 3 cases were invalid (10.0%), the total effective rate was 90.0% |
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| [Traditional usage] |
1. Chronic toothache due to kidney deficiency 2. Loss of appetite due to spleen and kidney deficiency 3. Loose stool or diarrhea in the early morning due to spleen and kidney deficiency 4. Yang deficiency of spleen and kidney, borborygmus and diarrhea, oppression in the chest, indigestion |
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| [References] |
Chemical Composition： [1]State Administration Of Traditional Chinese Medicine Material Medical Editorial Board .Chinese Material Medical .Shanghai: Shanghai Scientific And Technical Publishers，1999,11:603(总3348). [2]Ji Li, Xu Zhiling.Chemical Constituents Of Fructus Psoraleae.China Journal Of Chinese Materia Medica,1995,20(2):120. [3]Huang Jian, Zhao Luhua, Zou Qiaogen,Advances In Research Of Chemistry And Pharmacology Of Psoralea Corylifolia L..Progress In Pharmaceutical Sciences,2000,24(4):212. [4]Chen Yegao, Yu Lili.Studies On The Chemical Constituents Of Fructus Psoraleae.Yunnan Normal University Journal,2005,25(4):52. [5]Luo Yichen, Liu Juan, Zhu Zhaorong.The Research Progress Of Psoralen.Chinese Journal Of Veterinary Medicine,2007,(5):49. [6]Yang Tongtong, Qin MJ.Psoraleae New Isoflavone Composition Separation And Structural Identification.Journal Of Pharmaceutical Sciences,2006,41(1):76. Pharmacological Effects: [1]Nanjing College Of Pharmacy.Chinese Herbal Medicines（Zhongce）.The First Edition. Nanjing: Jiangsu People's Medical Publishing House,1976:487. [2]Kabhnob H M,Dpapmakon N Tokcnkon,1962,25(6):733. [3]East J,J Endocrinology,1955,(12):261. [4]Zahirnddin K .Pakistan J Sci And Ind Res,1975,18(1～2):54. [5]Wu Huan.Chinese Herbal Medicines ,1978,(10):464. Clinical Trials: [1] Ye Zhixiong Qin Cunheng.Homemade Fructus Psoraleae Decoction And Calcitonin In Treating Senile Osteoporosis: A Clinical Comparative Study.China Medical Herald.,2005,12(7):834. [2] Cai Weiqing Wu Yaochi.Fructus Psoraleae Decoction For The Treatment Of Femoral Head Necrosis: Clinical Observation Of 30 Cases.Shanghai Journal Of Traditional Chinese Medicine,2007,41(8):51.[3] Qiao Lihua Chen Yaqing.Treatment Of Viral Defects With Compound Fructus Psoraleae Curative Effect Observation.Journal Of Dermatology And Venereology,1996,18(4):61. [4] Li Hui.The Treatment Of Common Warts, Plantar Warts At The Same 42 Cases.Jilin Journal Of Traditional Chinese Medicine,1999,(5):834. [5] Lu Yongtian.Psoralen Injection In The Treatment Of Psoriasis: Clinical Observation Of 800 Cases.Journal Of Traditional Chinese Medicine,1982, (9):31. [6] Peng Daoxian.Internal And External Treatment Of 20 Cases Of Alopecia Areata. Henan Doctor Of Traditional Chinese Medicine,2002,11(6):19. [7] Yuan Xinshun.Comprehensive Therapy Of Traditional Chinese Medicine In Treatment Of 34 Cases Of Alopecia Areata. Chinese Folk Remedies,2004,12(7):38. [8] Liu Weishun, Du Chunling, Tu Ming, Etc..Psoralen Preparations In The Treatment Of Acute Attack Of Bronchial Asthma. Clinical Curative Effect Observation Of Department Of Internal Medicine Magazine,2003,20(11):604. Toxicology: [1]Traditional Chinese Medicine Research Institute Of Traditional Chinese Medicine Research Center Of Family Planning Research Of Traditional Chinese Medicine Information [2]Zhang Yushun, Etc..Chinese Materia Medica,1981,6(3):30 [3]Li Xiaoyu, Etc.Chinese Society Of Physiological Science Conference Abstracts.1964:52 [4]Dunnick J K.Ct Al.Nad Cancer Instmonogr,1984,(66):91 |
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