It contains alkaloids, amino acids and aliphatichydrocarbon ^[1].

Alkaloids: broussopapyrineA, nitidine, liriodenine, isoterihanine, oxyavicine ^[2].

Amino acids: serine, glycine, alanine, lysine, histidine, aspartic acid, arginine, threonine, glutamic acid, proline, cystine, methionine, isoleucine, leucine, tyrosine, phenylalanine, valine ^[3].

Aliphatichydrocarbon: nonanoic acid, lauric acid, tetradecanoic acid, n-pentadecanoic acid, palmitoleic acid, hexadecanoic acid, 9,12-octadecadienoic acid, heptadecanoic acid, 8,11-octadecadienoic acid, n-octadecanoic acid, nonadecanoic acid, 11,13-eicosadienoic acid, 11-eicosenoic acid, eicosanoic acid, ethyl linoleate, docosanoic acid, tricosanoic acid, ethylpalmitate, 2-heptenal, undecane, methyl octanoate, trans-2- decenal, 10,13-octadecadienoic acid, 2,4-decadienal, 9-octadecadienoic acid, methyl 8-oxooctanoate, cycloisosativene, cyperene, trans- caryophyllene ^[3,4].

1.Anti-oxidant: Flavonoid compounds isolated fromthe root bark of Papermulberry has versatile capacity of free radicalscavenging^[1]; a strong lipid anti-oxidation function on cerebralhomogenate of mice caused by Fe^{2+ [2]}.

Total flavonoids of Papermulberry has cellprotection role^[3]; also have protective effects on cell oxidativedamaged by UVA ^[4].

2. Anti-platelet aggregation: Flavonoid compoundsisolated from the root bark of Papermulberry has significantly anti-plateletaggregation function ,which was induced by arachidonic acid ^[5].

3.anti-inflammation and anti-allergy: Flavanone derivative isolated from the root bark ofPapermulberry inhibit passive cutaneous anaphylaxis reaction and activity ofsecretory phospholipase A2 ^[6].

4.anti-aging: PapermulberryFruit has anti-Alzheimer's or delaying Alzheimer's role ^[7], andalso has effects on promoting learning and improve memory ^[8].

5. anti-microbial: Flavanone derivative separatedfrom the root bark of Papermulberry have antibacterial and cytotoxic activities^[9].

Taste: sweet; property: cold; belong to liver, kidney, spleen chnnels.

Oral administration: decoction, 6-10g, also can used in vinum, pill, or powder.

External application: spread on the skin with smashed powder.

Carefully use in mad patients who with the syndrome of deficiency-cold in spleen and stomach, diarrhea.

1. All involved syndromes obstructing the eye, dryness and pain. Photophobia, pterygium and cold or hot tearing.

2. Clouded vision

3. Yin deficiency of spleen, kidney and liver, hematemesis, hemoptysis, hectic fever and night sweating, bitter taste in mouth and

polydipsia, nocturnal emission; dry stools, dysuric stranguria; or clouded vision, lacrimation induced by wind

4. Tympanites, diuresis

5. Edema

1.Quanlv Pill：venison,psoralea fruit(stir-frying with salt water), songaria cynomorium herb(stir-fryingwith wine), eucommia bark(stir-frying with salt water), dodder seed,desertliving cistanche, papermulberry fruit, faenum graecum(stir-frying withwine), morinda root, dipsacus root(stir-frying with salt water), pricklyashpeel, common fennel fruit(stir-frying with wine), schisandra fruit(steaming),palmleaf raspberry fruit, gordon euryale seed, dangshen, milkvetchroot(stir-frying), poria, white atractylodes rhizome(stir-frying), chinese yam,stir-fried liquorice, prepared rehmannia root, chinese angelicaroot(stir-frying with wine), cochinchinese asparagus root, ophiopogon root,wolfberry fruit(stir-frying with salt water), dried rehmannia root, halite,tangerine peel, eagle wood, achyranthes root, chuanxiong rhizome(stir-fryingwith wine).

2.Xialing Granule：preparedfleece flower root, wolfberry fruit, black sesame(stir-frying), mulberry fruit,dodder seed, papermulberry fruit, siberian solomonseal rhizome(prepared),hawthorn fruit, notoginseng, chrysanthemum flower.

3. HuanshaoCapsule：preparedrehmannia root, chinese yam(stir-frying), wolfberry fruit, dogwood fruit,schisandra fruit, achyranthes root, papermulberry fruit, eucommiabark(processing with salt water), morinda root(stir-frying), common fennelfruit(processing with salt water), desertliving cistanche, polygala root（stir-fryingwith liquorice）,grassleaved sweetflag rhizome, poria, chinese date(stoned).

4.Beyuntuiyi Pill：cicadaslough, snake slough, common scouring rush herb, pale butterflybush flower,puncturevine caltrop  fruit(stir-fryingwith salt water), chrysanthemum flower, schizonepeta, shrub chastetree fruit,peppermint, coptis root, wolfberry bark, papermulberry fruit, trichosanthesroot, chinese angelica root, chuanxiong rhizome, pricklyash peel, liquorice.

Chemical composition:

[1] State Administration of Traditional Chinese Medicine "Chinese Materia Medica" Editorial Board. Chinese Materia Medica. Shanghai: shanghai scientific and technical publishers, 1999,5:470(total 1021).

[2]SQ Pang. Antiaging constituents and quality evaluation of Fructus Broussonetiae. Master Degree Thesis of The Second Military Medical University. 2006

[3]BK Huang, LP Qin, HC Zheng ets. Analysis of amino acid and fatty acid of fructus Broussonetiae. Journal of The Second Military Medical University. 2003,(2):213

[4]X Yuan, P Yuan. Analysis on chemical constituents and contents of oil from Broussonetia papyrifera fruits. Journal of Plant Resources and Environment, 2005,14(1):54．

[5]MATSUMOTO J, FUJMOTO T, TAKINO C, etal. Components of Broussonetia papyrifera (L.)Vent. I. structures of two new isoprenylated flavonols and two chalcone derivatives.Chem Pharm Bull, 1985, 33(8): 3250．

[6]FUKAIT, IKUTA J, NOMURA T. Constituents of the cultivated mulberry tree Part XXXII. Components of Broussonetia papyrifera (L.)Vent. III. structures of two new isoprenylated flavans, broussonflavonols C and D.Chem Pharm Bull, 1986, 34(5): 1987．

[7]FANG SC, SHIEH BJ, LIN CN. Phenolic constituents of Form osan Broussonetia papyrifera.Phytochemistry, 1994, 37(3):851．

[8]JANG DⅡ, LEE BG, JEON CO, et al. Melanogenesis inhibitor from Paper mulberry.Cosmet Toiletries, 1997, 122 (3):59．

[9]IKUTA J, HANO Y, NOMURA T. Constituents of the cultivated mulberry tree. Part XXXI Components of Broussonetia papyrifera(L. )Vent. 2 structures of two new isoprenylated flavans, kazinolsA and B.Heterocycles, 1985, 23(11): 2835．

Pharmacological Effect:

[1]Cheng Zj,Lin Cn,Hwang Tl,Et Al. Broussochalconea,Apotent Antioxidant And Effective   E Suppressor Of Inducible Nitric Ox-Ide Synthase In Lipopolysaccharide-Activated Macroph   Ages. Biochem Pharmacol, 2001,61(8):939.

[2] Ko Hh,Yu Sm,Ko Fn,Et Al. Bioactive Constituents Of Morusaustralis And Broussonetia Papyrifera. J Nat Prod, 1997,60(10):1008-1011. 12(23):3387.

[3] Yang Xueying, He Rui, Wang Ting, Et Al. Total Flavonoids Of Broussonetia Papyrifera In Immortalized Keratinocytes Protective Effect. China Public Health,2004,20(7):794

[4] Pavilion, Where Yang Xueying, Swiss, And So On. Protective Effects Of Total Flavonoids Of Broussonetia Papyrifera On Oxidative Injury Of Ultraviolet A To Human Keratinocytes. The Labor Health Occupation Disease Journal,2005,23(6):442

[5]Lin Cn,Lu Cm,Linhc,Et Al. Novel Antiplatelet Constituent From Formosan Moraceousplants. J Nat Prod,1996,(9):834.

[6]Kwakwj,Moon Tc,Liu Cx,Et Al. Papyriflavonola From Broussonetia Papyriferainhibits Th   E Passive Cutaneous Anaphylaxis Reaction And Has A Secretory Phospholipase A2-Inhibitory Activity. Biolpharm Bull,2003,26(3):299.

[7] Zhang Zunxiang, Dai Xinmin, Yang Ran, And So On. Paper Mulberry Fruit On Senile Dementia Of Blood Lpo, So And Influence Of Lipoproteins. Pharmaceutical Journal,1999,15(4):5

[8] Wearing Xinmin, Zhang Zunxiang, Fu Zhongxian, And So On. Paper Mulberry Fruit On The Learning And Memory Of Mice And Promote Action. Pharmacology And Clinic Of Chinese Traditional Medicine,1997,13(5):27

[9] Sohnhy, Sonkh,Kwon Cs,Et Al. Antimicrobial And Cyto-Toxic Activity Of 18 Prenylated Flavonoids Isolated From Medicinal Plants:Morusalbal,Morusmongolicaschneider,Broussonetia Papyrifera(L.)Vent,Sophora Flavescens Ait And Echinosophora Koreensis Nakai. Phytomedicine,2004,11(7/8):666.