| [English Name] | Belvedere Fruit | |
| [Chinese Name] | 地肤子 | |
| [Pinying Name] | Difuzi | |
| [Latin Name] | Kochiae Scopariae Fructus | |
| [Genera] | Chenopodiaceae | |
| [Efficacy] | Damp-clearing drug | |
| [Pictures] | Plant picture | Drug picture |
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| [Ecology] | It grows in moutains waste land、field、road side,is cultivated in garden,the loam exposed to the sun,with rich humus and good drainage is optimum. | |
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| [Pharmacological activities] | 1 Anti-pathogenic microorganism: Fructus Kochiae Scopariae have various degrees of inhibitory effect on different dermatophytes [1-2]. Lin xiuxian et al [3] Fructus Kochiae Scopariae extracted by sub-supercritical CO2 extract implement anti-Trichomonas experimental, the results show that the different conditions of the supercritical extract have a strong inhibition of Trichomonas vaginalis effect, the minimum drug concentration of 320-1280 μg / mL. Lin xiuxian et al [4] investigated the Fructus Kochiae Scopariae oil antibacterial activity, the results show that supercritical extracts from Fructus Kochiae Scopariae have good antibacterial activity. 2 Anti-inflammatory and anti-allergy: Fructus Kochiae Scopariae inhibit the mononuclear phagocyte system and DTH, and the effect of FKS on DTH may be related to its suppression to the function of mononuclear phagocyte system [5]. FKS inhibited immediate hypersensitivity and the early phase of DTH mainly due to its stabilization of mast cell membrane and reduction of release of histamine, 5 HT and other anaphylactic mediators, and inhibited the late phase of DTH may be due to its anti inflammatory activity. Saponin was the active component of FKS responsible for its inhibition on DTH [6-10].3 Hypoglycemic function: NBFK 50mg/kg markedly inhibited gastric emptying in normal mice, and it more potently inhibited gastric emptying in hyperglycemic and hypoglycemic mice induced by oral administration of glucose, intravenous injection of alloxan and subcutaneous injection of insulin, respectively. NBFK concentration-dependently decreased the activities of sucrase, maltase and lactase in rat intestinal mucosa, and inhibited glucose absorption in rat small intestines. The hypoglycemic mechanism of NBFK is probably contributed by inhibition of transport and transformation of sugar in the digestive tract and absorption of glucose via the membranes of the small intestine [11-13].4 Anti-gastric Mucosal Injury function: NBFK 50mg/kg more potently accelerated PFSM in mice pretreated with fenfluramine, dopamine, acetic acid and Nω nitro L arginine than in normal mice. However, in atropine pretreated mice, the accelerative effect of NBFK on PFSM disappeared. NBFK improves the propulsive function of small intestine, and the mechanism of action probably involves cholinergic nerve and nitric oxide [14,15]. | |
| [Clinical trial] | 1. Urticaria: Belvedere Fruit were boiled with water and patients drink the decoction twice each day. Residue were wrap by cotton gauze and embrocated at the spot area of urticaria. Results: most patients were cure within seven course of treatment. 44 cases of patients were treated with Belvedere Fruit, 31 cases were showed significant effect(70.4%) and nine cases were improved (20.4%), four cases were invalid(9.2%)[1]. 2. Hepatitis B: Chinese paten drug--Difuzi Pill--were used to treat the disease of chronic Hepatitis B. results showed that 20 cases were cure (23.3%), 46 cases had significant effects, 15 cases had effects and five cases were invalid, the effective rate were 94.2%[2]. |
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1. Eczema of scrotum 2. Headache with tinnitus 3. Nephritic edema 4. Dysuria caused by qi and yin deficiency 5. Chronic hematodiarrhea 6. Erysipelas 7. Sore 8. Eczema, prurigo 9. Acute mastitis 10. Stranguriaduring pregnancy, frequent but short urine with sudden pain and sore, pain onhands and feet |
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| [References] |
Pharmacological Actions: [1] [2] Ren-lie Cao, Zai-yuan Sun, Zhong-de Wang et al., Effects of flooding agent in the observation of the in vitro anti-fungal skin, Chinese Journal of Dermatology, 1957, (4): 286. [3] Xiu-xian Lin, Jing Li, Shu-hua Zhang, Kochia scoparia supercritical CO2 extract of anti-Trichomonas vaginalis pharmacodynamic, Journal of Chinese Medicinal Materials, 2005, 1 (28): 44-45. [4] Xiu-xian Lin, Jing Li, Antibacterial Activity of Kochia scoparia oil supercritical extraction, Journal of Chinese Medicinal Materials, 2004, 27 (8): 603-604. [5] Yue Dai, Luo-sheng Huang, Guo-xiong Feng et al., Kochia scoparia inhibition of monocyte-macrophage system and delayed type hypersensitivity, Journal of China Pharmaceutical University, 1994, 25(1): 44-48. [6] JIubaodaode, Songtianxiuqie, Daiyue et al., Journal of Medicine, 1997, 117 (4) : 193-201. [7] Matsuda H，Dai Y，Ido Y，et al． Studies on Kochiae Fructus Ⅲ: Antinocicep tive and anti inflammatory effects of 70% ethanol extract and its component，momordin Ic from dried fruits of Kochia scoparia L． Biol Pharm Bull，1997，20 (10): 1086-1091． [8] Matsuda H，Dai Y，Ido Y，et al． Studies on Kochiae Fructus Ⅳ: Anti-allergic effects of 70% ethanol extract and its component，mo-mordin Ic from dried fruits of Kochia scoparia L． Biol Pharm Bull，1997, 20 (11): 1165-1170． [9] Yue Dai, Yu-feng Xia, Hai-biao Chen et al., Kochia scoparia 70% ethanol extract inhibits the rapid onset and delayed type hypersensitivity, China's modern pharmaceutical journal of application, 2001, 18 (1): 8-10. Clinical trials: [1]Liu ChaoZhong. Summary of Kochiae Scopariae Fructus for Urticaria in 44 Cases. Jilin Medical Journal, 1980,（4）:42. [2]Zhu QinHou. Kochiae Scopariae Fructus for Hepatitis B in 86 Cases. Shaanxi Journal of Traditional Chinese Medicine,1999,20（9）：400. |
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