[English Name] | Cholla Stem | |
[Chinese Name] | 仙人掌 | |
[Pinying Name] | Xianrenzhang | |
[Latin Name] | Caulis Opuntiae | |
[Genera] | Cactaceae | |
[Efficacy] | Qi-regulating drug | |
[Pictures] | Plant picture | Drug picture |
|
|
|
[Alias] | ||
[Source] | ||
[Plant morphology] | ||
[Distribution] | ||
[Gathering and processing] | ||
[Characteristics] | ||
[Ecology] | It originats in tropical、subtropical dry regions or desert.It survives with the help of moisture keeped in stem,in the conditions that soil and the air are very dry,doesn’t grow in the soil,is epiphytic in tree trunk and rock which in valley. | |
[Chemical composition] | ||
[Pharmacological activities] |
1. Anti-inflammatory and analgesic: with 100mg/kg fresh cactus water decoction by gavage or intraperitoneal injection for 6 to 8 days in a row, xylene induced mouse ear swelling, abdominal capillary permeability caused by acetic acid and granuloma in mice can be significantly inhibited; 25g crude drug/kg, 50g crude drug/kg orally, rat agar paw swelling, acute exudative inflammation of the egg white paw swelling and the mouse ear have significant inhibition effect, on the acute and chronic inflammation shows significant inhibition [1, 2]; cactus water extract 1g crude drug/ig for seven days in a row, can promote the phagocytosis of mouse peritoneal macrophages[3]. Cactus stems, fruits or stems and fruits of a mixture has analgesic and anti-inflammatory effects, flavonoids in the cactus plant has a significant analgesic effect on mice [4]. 2. Antibacterial and antiviral: ethanol and water extract of the cactus on Bacillus subtilis, Streptococcus, alpha hemolytic streptococcus, Streptococcus pneumoniae, Staphylococcus aureus and other Gram-positive bacteria was significantly inhibited role, the effect of E. coli and other gram-negative bacteria is relatively somewhat less, on Rhizopus nigricans, Aspergillus fungi effect is very small, the antibacterial activity of water extract them from the dry powder of the flowers is the best [5]. Cactus extract can inhibit the DNA and RNA [6] of herpes simplex virus typeI, the horse herpes virus, influenza virus and HIV (HIV-1) of the replication. 3. Down glucose: fresh actus 30g/kg orally, 7 hours later, can reduce blood glucose in normal mice. Dry cactus the decoction alcohol sediments 22.5g/kg gavage, 7 hours later, reducing blood glucose of normal mice [7]. Cactus 0.75% of acidic water extract are given intraperitoneal injection of 200mg/kg, 400mg/kg, six days in a row, can significantly reduce the blood glucose of normal mice alloxan-induced diabetic mice, the hypoglycemic effect follows a dose relationship [8]. Cactus polysaccharide 150mg/kg, 200mg/kg, 250mg/kg orally, can reduce the blood glucose [9] in diabetic mice, 4. Lowering blood pressure: the pectin extracted from cactus, 3% content added to the feed containing 0.25% cholesterol and feed guinea pigs, can reduce LDL levels in the blood, liver free and bound cholesterol are down 40 % and 85%. the mechanism to lower plasma cholesterol levels may be the same to bile acid binding resin, it could increase bile acid excretion, and block the enterohepatic circulation [10]. Cactus powder 3g /day, 6g /day, 9g / day administered orally for 21 days, can significantly reduce the serum cholesterol of experimental hyperlipidemia in, LDL cholesterol and atherogenic index, triglyceride esters, and its lipid-lowering effects follows dose-relationship [11]. 5. Anti-gastric ulcer: cactus alcohol extract of 32g/kg and 8g/kg gavage in rats has significant therapeutic effect on stomach gastric ulcer under stress type, indomethacin, pyloric ligation, and can certainly improve the E2 content [12] of gastric juice prostaglandin. The Cactus aqueous extract ethanol sediments 17.2g/kg, 8.6g/kg and 4.3g/kg administered orally, can inhibit gastric ulcer caused by reserpine in mice to inhibit gastric acid secretion, reduce gastric acidity, as well as reduce the activity of pepsin the same time, and keep the prostaglandin E2 secretion balance, promote healing of ulcers [13]. 6. Cancer: cactus fruit extract can inhibit cancer cell proliferation of cervical cancer, ovarian cancer and bladder cancer, the role equall to the ovarian cancer prevention drug 4-N hydroxy-dimensional methylamine, its inhibitory effect on tumor cell growth related with apoptosis in cancer cells and cancer cells extending residence time [14] in the G phase. Cactus5in flavonoids can increase the concentration of intracellular calcium, and interfere the interleukin-2 expression [1], of the conversion to S phase of human T-cell related. 7. Antioxidant, anti-aging: cactus decoction of 1.5g crude drug/mL and 0.75g of crude drug/mL in vitro can significantly inhibit the malondialdehyde ( MDA) generation in mouse and rat liver homogenate induced by CCl4 , 30g crude drug/kg, 60g crude drug / kg administered orally can significantly reduce the content of MDA caused by CCl 4 in the mouse liver tissue [16]. Cactus powder 1.25g / 2.5g /day and 5g / day administered orally, significantly reduce the MDA content in serum and serum superoxide dismutase (SOD) activity is certainly higher than the control one. The cactus can certainly prolong half the time of death of Drosophila, the average life expectancy and maximum life [17]. Cactus polysaccharide 200mg/kg, 400mg/kg ig can significantly reduce the activity of aspartate aminotransferase (AST), alanine aminotransferase (ALT) in hyperlipidemia rat liver, significantly reduce the heart MDA content, accelerate the anti-O2 - and SODactivity to strengthen the heart, its antioxidant effects may be related to clear the body of oxygen free radicals and lipid peroxidation [18]. 8. Immune Enhancement: cactus extract 1.25g/kg and 2.5g/kg orally for 10 consecutive days, significantly increase the spleen index, peritoneal macrophages of phagocytosis and peripheral blood WBC count, has a certain role to enhance immune function[19]. Cactus polysaccharide200mg/kg, 400mg/kg gavage, a significant increase in immune suppression by cyclophosphamide-induced of murine macrophage phagocytosis rate, white blood cells, slowing the immunosuppressed mice red blood cell count, increasing pathological, to reduce the number of platelets and improve immunity to inhibit the hemolytic activity of the activation pathway of mouse complement bypass, can enhance immune suppression of non-specific immune function in mice [20]. 9. The role of acute liver injury: cactus polysaccharide 200mg/kg, 400mg/kg orally administered for 30 days, can significantly inhibit the serum ALT AST and liver content of MDA increasing of CCl 4- induced mice liver injury, liver can reduce the activity of SOD, glutathione S-transferase, glutathione peroxidase and imrpove the glutathione content significantly. And reduce the pathological changes of liver tissue, it tells that cactus polysaccharide has a protective effect on CCl4 induced liver injury in mice. Antioxidant capacity of glutathione system [21, 22] may be related. |
|
[Clinical trial] | ||
[Properties] | ||
[Medical and other Uses] | ||
[Dosage] | ||
[Cautions] | ||
[Traditional usage] |
1. Burns 2. Eczema, impetigo 3. Infantile head tinea favosa 4. Lung-heat cough 5. Palpation, insomnia 6. Mumps 7. Tuberculosis of cervical lymph nodes 8. Stomachache 9. Acute gastritis, ulcer of stomach and duodenum, excessive gastric acid 10. Lumps 11. Acute bacillary dysentery 12. Hematochezia 13. Bleeding hemorrhoids |
|
[Toxicological studies] | ||
[Pharmaceutical preparations] | ||
[References] |
化学成分: [1] Jiang Jianqin, Xu to first. The cactus chemical composition of Chinese Pharmaceutical Journal, 2000,35 ( 12): 805 [2] State Administration of traditional Chinese materia medica editorial board. " " Chinese materia medica. Shanghai: Shanghai science and Technology Press, 1999,6:866 ( total 1523). 药理作用: [1]Chen Shubing, Tang Yuwen, Meng Hua-min, et al. Study on the anti-inflammatory effect of cactus. Pharmacology and clinic of Chinese traditional medicine, 1991,7 ( 6): 33 [2] Wang Guiqiu, strong Ling, Zhang Hongmei, et al. Experimental study on the anti-inflammatory effect of cactus. Harbin medical journal, 1991,11 ( 4): 45 [3] Zhang Wenzhi, Zhang Jiangyan, Yan Qinglian, et al. Cactus extract on mouse macrophage phagocytic function influence experimental study . Liaoning Journal of TCM, 1990,14 ( 2): 43 [4] Wei Guofeng, Li Zhenzhong, Huang Zuliang, et al. A cactus plant extracts and its experimental study on the analgesic effect. Lishizhen medicine and Materia Medica Research, 2006, 2133 ( 11 ): L7 [5] Yu Zhonghua, Zhao Chao, Jia De-feng, etc. The cactus extract different antibacterial effect. Chinese Journal of tropical crops, 2008,29 ( 02): 237 [6]Ahmad A. Antiviral Res,1996,30:75. [7] Chen Fujun pharmacology and clinic of Chinese traditional medicine, 1992,8 ( Supplement): 60 [8] Jiang Jianqin, Li Peizhen, Xiao Wendong, et al. Study on hypoglycemic effects of extract of cactus. Basic Med, 1996,10 ( 1): 40 [9] Tao Meihua, once Fu, Lu Xiang-Yang, etc. Of cactus polysaccharide hypoglycemic effect. Journal of Hunan Agricultural University ( NATURAL SCIENCE EDITION ), 2005, [10]Iuz Fernandez M.J Nutr, 1990, 120(11):1283. [11] Li Chunyan, Cui into Komatsu, beach, and so on. Cactus powder on blood lipid in rats and its mechanism. Chinese Journal of medicine, 2005,30 ( 9): 694 [12] Cui Jingzhao, Zhou Ruiling, Chen Yuxing. Experimental study on anti ulcer action of cactus. Lishizhen medicine and Materia Medica Research, 1998, ( 5): 406 [13] Li Ping, Li Yan. Cactus extract on gastric mucosal protective effect of experimental research. Journal of Guangxi Traditional Chinese Medical University, 2002,5 ( 04) :3. [14]Zou DM. Nutr J,2005,4(1):25. [15]Aires V. Mol Cellular Biochem,2004,260(1-2):103. [16] Chen Shubing, Meng Hua-min. Cactus anti lipid peroxidation of pharmacology and clinic of Chinese traditional medicine, 1997,13 ( 3): 36 [17] Cui Meizhi, Liu Hao, Li Chunyan. Cactus powder antioxidant anti-aging effect and the study of its mechanism. Chinese Journal of clinical rehabilitation, 2004, ( 24): 5052 [18] Yang Xiaozhou, Huang Wei, once Fu, etc. Of cactus polysaccharide on experimental hyperlipidemia rats antioxidant effects in vivo study. Lishizhen medicine and Materia Medica Research, 2009,20 ( 10): 2440 [19] Wang Guiqiu, Yao Yuemei, Xu Wei. Cactus extract on immune function in mice. Chinese medicine journal, 2001,29 ( 04): 38 [20] Zhang Songlian, Lan Qijie, once Fu, and so on. Cactus polysaccharide on mice non-specific immunity. Journal of Zhanjiang Normal University, 2007,28 ( 3): 95 [21] Yu Ninghua, Rao had Fu, group, etc. Of cactus polysaccharide on acute liver injury in mice. Journal of Zhanjiang Normal University, 2007,28 ( 6): 96 [22] Yu Ninghua, Rao had Fu, group, etc. Of cactus polysaccharide on acute liver injury in mice. Chinese Pharmaceutical Journal, 2009,30 ( 4): 255 临床试验: [1] Luo Dongsheng fresh cactus juice in Treating 50 cases of herpes zoster. Jiangxi Journal of traditional Chinese medicine, 2004,35 ( 6) :34. [2]Guan Yimin, easy Wande. Cactus Daolan topical therapy for 126 cases of parotitis. Journal of Practical Traditional Chinese medicine, 2006,22 ( 1) :31. [3] Lu Lijun cactus and alum in treating infantile parotitis : analysis of 32 cases. Chinese Journal, 2007,7 ( 22) :5378. [4] Zheng Jinhong, Liu Guangjun, Wu Xuefang . The external application of cactus to treat 32 cases of epidemic parotitis report. Clin stomatol, 2007,23 ( 6) :373. [5] Huang Min cactus multiple skin irritation test and treatment of sunlight dermatitis . Observation on curative effect of Sichuan Traditional Chinese medicine, 2006,24 ( 11) :79. [6] Li Yulan cactus in prevention and treatment of chemotherapy induced phlebitis in 178 cases of effect observation . Qilu Nursing Journal, 2008,14 ( 5) :112-113. [7] Zhao Xiang, Yang Junchao, Tong Zhong hang. Cactus tablets in the treatment of type 2 diabetes mellitus. Chinese Journal of integrated traditional and Western medicine, 2000,20 ( 6) :456-458. [8] Meng Xiulin, lake between cactus to treat 18 cases of the. . Chinese folk medicine, 2006,14 ( 1) :25-26. [9] Zhang Yuliang, Ren De, Wang Xiucai. A cactus in treating 61 cases of peptic ulcer clinical observation. Hainan medical journal, 1995,6 ( 2) :87-88. [10] Chen Yong. " The cactus Decoction in treating 76 cases of chronic hepatitis B. Journal of Guangxi Traditional Chinese Medical University, 2003,6 ( 2) :23-24. 毒理学: [1] Zhao Shenglan, Zhou Lingxian, Chen Zhaoyin, etc. The cactus powder on acute toxicity and mutagenicity test. Journal of toxicology, 2001,15 ( 03): 191 [2] Cheng Dong, Han Xiaoying, Feng Ning, et al. Study of toxicity of juice of cactus. Carcinogenesis. Distortion mutations, 2005,17 ( 1): 56 |