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[English Name] Indigowoad Root
[Chinese Name] 板蓝根  
[Pinying Name] Banlangen  
[Latin Name] Isatidis Radix  
[Genera] Cruciferae
[Efficacy] Antipyretic drug
[Pictures] Plant picture Drug picture
Plant picture
 
Drug picture
 
[Alias]  
[Source]  
[Plant morphology]  
[Distribution]  
[Gathering and processing]  
[Characteristics]  
[Ecology]     It gows in moist place in moutain forest.Wild or cultivation. Strong adaptability,no strict damand of nature enviroment.It prefers warm and miost climate,resistants to cold,avoids drought and waterlogging;is suitable for being planted in the soil with thick soil layergood drainageloose and  fertilization.  
[Chemical composition]

This plant contains alkaloid: isatin[22], indigotin[22], indoxyl-8-glucoside[1], 2,5-dihydroxy-indole, 2,3-dihydro-4-hydroxy-2-oxo-indole-3-acetonitrile[22], indole-3-acetonitrile-6-O-β-D-glucoside[2], hydroxylindirubin[3], (E)-3-(3,5-dimethoxy-4-hydroxy-benzylidene)-2-indolinone[5], isaindigodione[7], indirubin[10], tryptanthrin[2], isaindigotone[3], 3-(2′-hydroxyphenyl)-4(3H)-quinazolinone[7], 3-(2′-carboxyphenyl)-4(3H)-quinazolinone[10], 2,4(1H,3H)-quinazolinedione, 3-(2-benzoic acid)-4(3) quinazolinone [22], isaindigotidione[5], isatan A[17], isatan B, isatan C [22], isatan D [18];

organic acid: succinic acid[22], palmitic acid[6], 3-pyridinecarboxylic acid, maleic acid, 2-hydroxy-1,4-benzenedicarboxylic acid, benzoic acid, salicylic acid[22], syringic acid[8], 2-amino-benzoic acid[14], linolenic acid, erucic acid)[22];

flavone: (+)-isolariciresinol[5], neohesperidin[22], 1iquiritigenin[22], isoliquiritigenin[11], homovitexin[22], linarin[22], indigoticoside A[19];

anthraquinone: emodin[10], emodin-8-O-β-D-glucoside[12];

steridestriterpene: β-sitosterol[22], γ-sitosterol[22], daucosterol[22], polygalytol[6], lupeol, betulinol[22], lupenone[9];

glucosinolates: sinigrin, glucobrassicin, neoglucobrassicin[22], 1-sulpho-glucobrassicin[22].

sulfur compounds: epigoitrin[4], goitrin)[22], 1-thiocyano-2-hydroxy-3-butenen[13];

amino acids: arginine, glutamic acid, tyrosine, proline, valine, γ-aminobutyric acid, leucine, tryptophane, aspartic acid, threonine, serine, glycine, alanine, isoleucine, phenylalanine, histidine, lysine[15];

other: adenosine, uridine, pyrophaeophorbide a, guanine, hypoxanthine, uracil[22], qingdainone[22], deoxyvasicinone, homovitexin, linarin[22], phaeophytin[16], eupatorin, sinensetin[22], 3-formyl-indole[19], syringin[22], indole-3-acetonitrile-6-O-β-D- glucopyranoside[20], α, α′-dipalmitin[22], monopalmitin[21].

 
[Pharmacological activities]  
[Clinical trial]

Banlangen(Radixisatidis)

1 Acute pharyngitis: Compound banlangen(containsbanlangen(Radixisatidis), pugongying(dandelion), zihuadiding(purple flower violet), oral, 8-15 tablets every time, 3 times a day)with caoshanhu(grass coral)tablet (contain in mouth 2 tablets each, 6 times aday). 48 cases of acute pharyngitis; Cephalexin capsules (Oral, each 375mg, 3 times a day) with the caoshanhu tablet (Usageand dosage with the former group) 46 cases; Compound banlangen (Usage and dosage with the former group) with the cephalexin capsules (Usage and dosage with the former group) andcaoshanhu tables (Usage and dosagewith the former group) 52 cases of acute pharyngitis. All the groups of treatment time are 3-6 days. Results: 2 groups with compound banlangen effectivequick, control symptoms rapid, significantlybetter than the cephalexingroup (P <0.05)[1].

2. Subclinical genitalwarts: IRPS cream (banlangen multi-icing 10g, stearicacid 75g, white petroleum jelly 75g, themonoglycerides 30g, sorbic acid 5g Polysorbate-80 15g, the glycerine30g, polyethylene glycol 400 20g, add purifiedwater to 500ml), 60 cases ofsubclinical Condyloma Acuminatum, the control group use the stearic acid, white petroleum jelly and lanolin mixturewithout polysaccharide of banlangen cream, 60 cases. 2 groups areevenly coating the affected part, 2-3 times a day, a total of Application of 3months. Monthly visit, if a recurrence is in that do pathology relapse biopsy. Referral if relapseat the time of relapse, referral pathological biopsy.Results: Treatment group recurrence in12 cases, 48 cases recovered, control group, 28 cases of recurrence,32 cases recovered, the treatmentgroup was better than that of the control group (P <0.01) [2]..

3. Regular chronic nephritis: Radix isatidis injectionadd equivoluminal 10% glucose solution,treat 45 cases of chronic nephritis, Take the above solutioninjection bilateral renal hilus,foot three mile, per hole injection2ml every other day, 20 times as a course. Results: 12 cases fully mitigation,accounting for 26.7%;basic mitigation 11cases, accounting for 24.4%; partof the mitigation 16 cases,accounting for 35.6%; 6 cases invalid,accounting for 13.3%. The total effective rate was 39 cases, accounting for 86.7% [3].

 
[Properties]

Taste: bitter; property: cold; belong to heart, liver, and stomach channels.

 
[Medical and other Uses]

Function: clearing away the heat-evil and removing toxic agents, cooling the blood and relieving sore-throat.

Syndromes to be treated: heat toxin with skin eruption, fever headache, erythematous throat ulceration, erysipelas, mumps, inflammation of the throat, hepatitis, sores, chicken pox, measles, influenza.

 
[Dosage]

Oral administration: decoction, 1530g, large dose can be use to 60120g, or used in pill and powder.

Topical application: in right amount, smashed and smear on the skin, or wash with the decoction.

 
[Cautions]

Be carefully to be used in the patients with the syndrome of deficiency-cold of the spleen and stomach and patients without heat toxin.

 
[Traditional usage]

1.       Light or medium encephalitis B

2.       Epidemic cerebrospinal meningitis

3.       Influenza at early stage, high fever and headache, dry mouth and sore throat

4.       Pneumonia

5.       Influenza, scarflet fever, epidemic cerebrospinal meningitis, and epidemic encephalitis B

6.       Mumps

7.       Hepatitis

8.       Erysipelas

9.       Verruca plana

10.   Toxic plants and poisonous things being mistakenly eaten

11.   Scarflet fever

 
[Toxicological studies]  
[Pharmaceutical preparations]  
[References]

[1] Dengganlin. The curative effective observe of Compoundbanlangen treat 100 cases of acutepharyngitis. Shandong MedicalMedical College, 2002, 16 (2): 93

[2] Luo GuangPu. The treatment and local immune regulation effective ofBanlangen polysaccharide on subclinical genital warts. Modern skinthe journal Science, 2005, 2 (5):403.

[3] Liu Yueping Clinical observationof acupoint injection treatment of common chronic nephritis. Chinese acupuncture,2000, 12:725.