[English Name] | Common Andrographis Herb | |
[Chinese Name] | 穿心莲 | |
[Pinying Name] | Chuanxinlian | |
[Latin Name] | Herba Andrographis | |
[Genera] | Acanthaceae | |
[Efficacy] | Antipyretic drug | |
[Pictures] | Plant picture | Drug picture |
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[Plant morphology] | ||
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[Characteristics] | ||
[Ecology] | Common Andrographis Herb prefers warm and moist climate,is afraid of drought,if no watering and dry for a long time ,it grows slowly, narrow leaves, early flowering, yield is influenced. The optimum temperature of seed is between 25 to |
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[Chemical composition] | It contains flavonoid: andrographin, 5-hydroxy-7,8-dimethoxyflavanone[1], 5-hydroxy-7,8,2′,3′-tetramethoxyflavone, 5-hydroxy-7,8-dimethoxyflavone, panicolin[1,4], apigenin-4,7-dimethyl ether, 5-hydroxy-3,7,8,2′-tetramethoxyflavone, andrographidine A, andrographidine B[1], andrographidine C[1,4], andrographidine D, andrographidine E, andrographidine F[1], oroxylin A, wogonin[1], 5-hydroxy-7,8-dimethoxyflavanone, 5-hydroxy-7,8,2′,5′-tetramethoxyflavone, 2′-methoxyneobaicalein, 5,4′-dihydroxy-7,8,2′,3′-tetramethoxyflavone, dihydroxyneobaicalein, 5,7,8-trimethoxyflavanone, 5,7,4′-trihydroxyflavone, 5,7,3′,4′-tetrahydroxyflavone[4]; lactone compounds: andrographolide, 14-deoxyandrographolide, neoandrographolide, 14-deoxy-11,12-didehydroandrographolide, andrographoside,andrographolide-19-β-D-glucoside[1,3], 14-deoxyandrographolide-19-β-D-glucoside,14-deoxyandrographoside, 14-deoxy-12-methoxyandrographolide[1], andrograpanin[1,5], 3,14-di-deoxyandrographolide, isoandrographolide, di-andrographolide, deoxyandrographoside, 14-deoxy-11,12-didehydroandrographoside, 3,14-di-deoxyandrographolide, 19-hydroxy-8 (17),13-labdadien-15,16-olide,3-oxo-14-deoxy-andrographolide[3], 8-methylandrograpanin, 3-dehydrodeoxyandrographolide, 8(17),13-ent-labdadien-15→16-lactone-19-oicacid[2,5], andrograpanin[2]; phenolics: caffeic acid, chlorogenic acid, mixture ofdicaffeoylquinic acids, carvacrol, eugenol[1]; |
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[Pharmacological activities] | ||
[Clinical trial] | 1. Coronary heart disease: 35 cases of patients were treated with Chuanxinlian Flavonoids tablet, twice a day, one month continually. Results: 14 cases had significant effect (40%), 16 cases had effect(46%), the overall effective rate was 86%[1]. 2. Atheroscierosis of brain: 34 cases of patients were treated Chuanxinlian Flavonoids tablet, twice a day, one month continually. Results: 13 cases had significant effect(38%), 15 cases had effect(44), the overall effective rate was 82%[2]. 3. Condyloma acuminatum: Treatment group were given Chuanxinlian capsule, three times a day, three capsule for each time, 15 days as one course of treatment. Control group were given antiviral drugs. Results: all symptoms were disappeared in treatment group after one week and only three cases were recrudesced within three month, the overall effective rate was 90%, the cure rate was 88%; in the control group, two cases were became wound infection, many people pain in local, six cases were recrudesced, the overall effective rate was 67%, the cure rate was 61%, which had significant difference between the two groups (P<0.05)[3]. 4. Oral ulcer: 20 cases of patients were treated with Chuanxinlanneizhi dropping pill, taken after meals, one pack for each time, spicy and greasy food were forbiden. Results showed that all patients were cure within ten days[4]. 5. Asthmatic bronchitis: 51 cases of patients were treated with Chuanxinlanneizhi injection as the treatment group, one time a day, 8~10mg/kg for each time and no other antibiotic drugs were given; another 35 cases of patients were treated with antibiotic drugs, salbutamol and ketotifen as the control group. Treat time were both 5 days. Results: in the treatment group, 38 cases were cured, ten cases had effect, three cases were invalid, the overall effective rate was 94.1%; in the control group, eight cases were cured, ten cases had effect, 17 cases were invalid, the overall effective rate was 51.4%. Results indicated that effect between the two groups had significant difference (P<0.01)[5]. 6. Children virus pneumonia: patients were treated with Chuanxinlan injection as the treatment group and control group was given the ribavirin injection. Results: in the treatment group, 26 cases had significant effect, three cases had effect, one case was invalid, the overall effective rate was 96.7%; in the control group, 11 cases had significant effect, 13 cases had effect, six cases were invalid, the overall effective rate was 80.0%. The effect of treatment group was better than the control group with significant difference (P<0.05) [6]. 7. Bacillary dysentery: 136 cases of patients were treated with the Sanhuan tablet and Chuanxinlian as the treatment group, another 85 cases were treated with the Sanhuan tablet and furazolidone as the control group. Results: in the treatment group, 96 cases were cured, 23 cases had significant effect, 14 cases' condition had improved, five cases were invalid, the overall effective rate was 96.32%; in the control group, 32 cases were cure, 20 cases had significant effect, 15 cases' condition had improved, 18 cases were invalid, the overall effective rate was 78.28%. Significant difference was obtain between the two group s (P<0.05)[7]. |
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[Traditional usage] |
1. Acute and chronic laryngitis, canker sore 2. Influenza 3. Eczema of scrotum 4. Scald and burn 5. Venomous snake bite 6. Sinusitis, otitis media, conjunctivitis, toothache induced by stomach fire 7. Pneumonia 8. Fever caused by pulmonary tuberculosis (mild case) 9. Hypertension 10. Acute bacillary dysentery, enteritis 11. Heat stranguria 12. Ileotyphus 13. Acute appendicitis 14. Boil, cellulitis 15. Pertussis |
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[References] |
Clinical trial: [1] Pan Ping. Clinical investigation of Chuanxinlian Flavonoids tablet on the treatment of Coronary heart disease.Journal of Radioimmanology, 1999,12(1):30. [2]Tang LiHuan. The investigation of Chuanxinlian Flavonoids tablet on the treatment of Atheroscierosis of brain. Journal of Zhenjiang Medical College,2000,10(2),236. [3] He WenJie. Observation of therapeutic effect of Chuanxinlian capsule in treating Condyloma acuminatum. The Chinese Journal of Human Sexuality,2005,14(4):24. [4] Zhang XueLin. Chuanxinlanneizhi dropping pill in the Treatment of Oral ulcer.in 20 Cases. Modern Journal of Integrated Traditional Chinese and Western Medicine,2008 ,17 (22):3412. [5] Fan ChengLi. The effect of Chuanxinlanneizhi injection on treating Asthmatic bronchitis. Pharmacy and Clinical Remedies,2008,16(15):34. [6] Du ShengHua. Chuanxinlanneizhi injection in the Treatment of Children virus pneumonia in 30 Cases. China Journal of Experimental Traditional Medical Formulae,2006,12(5):64. [7]Yuan LiGen. Analysis of the Therapeutic Effect of Sanhuan tablet and Chuanxinlian in Bacillary dysentery. Journal of Yichun Medical College, 2001,13(2):201. |