Location:Home > Allii Bulbus > [Chinese]
[English Name] Allii Bulbus
[Chinese Name] 大蒜  
[Pinying Name] DaSuan  
[Latin Name] Garlic  
[Genera] Liliaceae
[Efficacy] jiedushachongyao
[Pictures] Plant picture Drug picture
Plant picture
 
Drug picture
 
[Alias]  
[Source]  
[Plant morphology]  
[Distribution]  
[Gathering and processing]  
[Characteristics]  
[Ecology]     It can be divided into purple skin garlic and white skin garlic by the colour of bulb cortex. Garlic clove of purple skin garlic is less and appearance is large, strong spicy taste, high output,mostly distributed in North, Northwest and Northeast of China, etc,weakly cold-resistance,mostly sowing in Spring, late maturity;There are big clove and small clove two kinds of white skin garlic,light spicy taste,more strong cold-resistance than purple skin garlic,mostly sowing in Autumn, slightly early maturity.  
[Chemical composition]

It contains volatile components: dimethyldisulfide, diallylsulfide, methylallylsulfide, methylallyldisulfide, propylallyldisulfide, diallyldisulfide, dipropenyldisulfide, diallyltrisulfide(allitridin), methylallyltrisulfide, dimethyl trisulfide, allylpropyltrisulfide, diallyltetrasulfide, methylallylpentasulfide, ajoene, 4-methyl-1,2-dithia-3-cyclopentene, 3-methyl-1,2-dithia-3-cyclopentene, 3-vinyl-1,2-dithia-4-cyclohexene, 2-vinyl-1,3-dithiin-4- cycolhexene, 3-vinyl-1,2-dithiin-5- cycolhexene, 6-methyl-1-thia-2,4-cyclohexadiene, 4-vinyl-1,2,3-trithia-5-cycolhexene, dithio-propenyl-propionate, 2-ethyltetrahydrothiophene[1];

Thiosulfinate: allicin(diallylthiosulfinate, allyl-1-propenylthiosulfinate, methylallylthiosulfinate, 1-propenylallylthiosulfinate, allylmethylthiosulfinae, methyl-1-propenylthiosulfinate, dimethylthiosulfinate[1];

amino acid: alliin(S-ally-L-cysteinsulfoxide), S-methylcysteinsulfoxide, cycloalliin, S-allyl-L-cysteine, S-propenyl-L-cystein, S-propyl-L-cystein, S-buty-L-cystein, S-allymercapto-L-cysteine, S-methylthio-L-cysteine[1], γ-L-glutamyl-L-phenylalanine, γ-L-glutamyl-S-methyl-L-cysteine, γ-L-glutamyl-S-methyl-L-cysteisulfoxide, γ-L-glutamyl-S-β-carboxy-β-propyl-L-cysteinylglycine, γ-L-glutamyl-S-allylmercapto-L-cysteine, γ-L-glutamyl-S-allyl-L-cysteine, γ-L-glutamyl-S-trans-1-propenyl-L-cysteine[1];

glycoside: scordinin A1, scordinin A2, scordinin A3, scordinin B1, scordinin B2, scordinin B3, quercetin, kaempferol[1], protieruboside B, astivoside B1[2];

 

polysaccharide: D-galactan, D-galacturonan, L-arabinan, D-glucan, D-fructan[1];

lipoid: neutrallipids, glycolipids, phospholipids, linoleic acid, palmitic acid, protoeruboside B, satioaide B1, protodesgalactotigonin[1];

It also contains allinase, polyphenoloxidase, hexokinase, L-serine-O-sulfatelyase[1], allixin, adenosine, 2,3-dimethyl-5,6-dithiobicyclo[2.1.1]hexane-5-oxide, Z,Z-d,l-2,3-dimethyl-1,4-butanedithio-S,S′-dioxide[1].

 
[Pharmacological activities]

1 Antibacterial and antiviral effect: Garlic has a significant antibacterial effect on Shigella dysenteriae in vitro [1]. The antibacterial mechanism of allicin maybe interfere with thiol reductase system of electronic transfer or antagonist with oxidative thiol reductase function [2]. Allicin has prevention and therapeutic effects on bone marrow transplant patients CMV infection [3].

2 The impact on cardiovascular: Intravenous injection of garlic leaching solution on anesthetized rabbits and dogs can cause short-term decline in blood pressure [4]. The main component of blood pressure lowering is the sugar ligands of garlic [5]. Allicin isolated from garlic can inhibit thoracic aortic strips caused by norepinephrine and KCl in rat, making norepinephrine and calcium chloride-induced aortic contraction weakened [6].  

3 Lipid-lowering and anti-atherosclerosis effect: Garlic oil has apparent protective effect on the feeding of cholesterol-induced rabbit hypercholesterolemia, high blood coagulation and aortic atherosclerosis lesions [7]. Allicin has lower blood cholesterol and triglyceride effect on experimental hyperlipidemic rabbits, and has clotting time prolonging and anti-atherosclerosis effect [8].

4 Inhibition of platelet pull aggregation and thrombolysis effect: Garlic oil can inhibit platelet aggregation induced by ADP, epinephrine and collagen, the inhibitory effect has a positive correlation with the dose [9]. The platelet aggregation inhibition rate of allicin is blood plasma concentration-dependent, and the inhibitory effect may be indirectly through plasma factors [10]. Garlic oil can inhibit the formation of thromboxane B2, by inhibiting the platelet peroxide enzymes, and this effect is correlated with the platelet aggregation inhibiting function of garlic oil [1112].

5 Antitumor mutations and blocking nitrosamine synthesis effect: Feeding female C3H/He mice with fresh garlic can completely inhibit the incidence of breast cancer, allicin may be its active ingredient [13]. Allicin can promote mitomycin C, cyclophosphamide and cisplatin-induced rat hepatocyte DNA program outside synthesis (UDS) which shows dose-response relationship, while allicin itself can not induce UDS. Allicin can promote the metabolic activation-free in cisplatin-induced UDS, and function by enhancing the ability of liver cells to repair DNA damage thus promoting UDS inducing role [14].

6 Hepatoprotective effect: Garlic oil has significant inhibitory effect on carbon tetrachloride (CCl4)-induced liver cell toxicity in the first generation cultured rat, and can reduce the formation of CCl3 free radicals under the action of CCl4 in rat liver microsomes [15].

7 Impact on immune function: The garlic water extract can enhance the cellular immunity, humoral immunity and non-specific immunity in immunocompromised mice [15]. Allicin can antagonist with the inhibition of tumor immunosuppressive factor on T cell activation in mouse sarcoma S180 cells and Ehrlich ascites cells [16].

 
[Clinical trial]

Clinical research:
1. The acute appendicitis:
Mashed Rhei Radix Et Rhizoma powder(10g) and garlic, mixed well. load to the shallow tank container, affected area with the mixture, one time a day. Results: the 33 cases effected(91.67%); 32 cases cured(88.89%); 3 cases invalided(8.33%)[1].

2. Chronic appendicitis: 35 cases in the treatment group were treated with “Da Huang Xiao Suan Fang”Rhei Radix Et Rhizoma 100g, 10 Allii Bulbus, sodium sulfate 100g, which was applied to affected area. Results: 28 cases were cured (80.0%), 5 cases were effective (14.3%), and the rest 2 cases invalided (5.7%), the total effective rate was 94.3%[2].

3. Allergic Rhinitis: Crushed garlic 300 g, and took it in rice 500 ml, soaked for one month. The patients smoked cover the garlic and vinegar solution for 30 min. Results: The rhinitis symptoms could improve or disappear in 3~7days using, long time usage could consolidate curative effect [3].

4. Bedsore: Preparation methods: (1) garlic lotions: cod liver oil 100 ml, garlic juice 10 ml, 0.5% novocain 1 ml, mixed standby. (2) the garlic liquid: physiological saline 100 ml, garlic juice 1 ml ~ 5 ml, 0.5% novocain 0.5 ml, mixed standby. Methods: patients takeing natural decubitus, exposed wound, 0.1% permanganate solution washed wound, 75% alcohol cleaned wounds, good garlic milk applied the wound, wrap with gauze, replaced every 1~2 days. Results: All the 27 cases” wounds were cured, 17 cases were cured in 1 ~ 10 days(62.96%); 8 cases were cured in 10 ~ 20 days(29.63%); 2 cases cured more than 20 days(7.41%)[4].

5.Acute bacterial dysentery: 45 cases were treated with “Yin Suan mixture”(garlic 1000g, tea 1200g, honeysuckle 320g, liquorice 120g, decoted into 400ml), 20 ml one time , 3 times a day, 3 ~ 7 days for a course. Results: 38 cases cured, 14 cases effected, 2 cases invalided. The total effective rate was 96.3%[5].

6.Residual empyemata and effusion after abdominal postoperative: garlic mud 100g and mirabilite powder 50g, mixed and wrapped with gauze, applied to affected area. 3~4 times a day, 30 min each time. Among the 30 cases, one week cure rate was 98% and recovery rate was 100%[6].

 
[Properties]  
[Medical and other Uses]  
[Dosage]  
[Cautions]  
[Traditional usage]

1.Edema

2. Venomous snake bite

3. Trichomonal vaginitis

4. Crymodynia in chest and abdomen

5. Incessant viscerotoxic hematockezia and emaciation caused by toxin wind inintestines

6. Malaria with cold limbs and pale complexion

7. Psoriasis

8. Duodenal ancylostomiasis

9. Infantile pertussis 

 
[Toxicological studies]  
[Pharmaceutical preparations]  
[References]

化学成分:

[1] State Administration of traditional Chinese materia medica editorial board. " " Chinese materia medica. Shanghai: Shanghai science and Technology Press, 1999,22:36 ( total 7128).

[2] Wang Ning, history Yanmei, Zhu Jun, et al. Garlic chemical compositions and methods for detection of foreign pharmaceutical botany fascicule, 2003,18 ( 5): 192

药理作用:

[1] Xu Zhonglv. Chinese medical journal, 1947,33 ( 3,4 ): 71

[2]Barone FE.Mycolegia,1977,69(4):793.

[3] Meng Yuesheng Hematol, 1992,13 ( 12): 627

[4] Zou Tianfu . Qingdao medical journal, 1957, ( 1): 14

[5] Wu Baojie herbal pharmacology. Beijing: People's Medical Publishing House, 1983:274.

[6] Chen Shuhua. Chinese pharmacological Sinica, 1988,9 ( 6): 533

[7]BordiaA.Atherosclerosis,1977,(26):379.

[8] Zhao Faji Journal of nutrition, 1982, ( 4): 109

[9]BordiaA.Atherosclerosis,1987,30:355.

[10] Jin Xiaojun, Peng Qingzhi, Xu Youzhi, et al. Effect of allicin on platelet aggregation function . Hubei medical journal, 1993,14 ( 01): 60

[11]Makheja AN.Lancet,1979,Ⅰ(8119):781.

[12] Han Jinxiang. Foreign medical Chinese medicine part, 1990,28:155.

[13] Deng Dajun. Chinese Pharmacological Bulletin, 1991,7 ( 5): 332

[14]HikinoH.PlantaMed,1986,52(3):163.

[15] Wei Yun, Tang Yinghong, selegiline. Garlic on immune function of mice. Chinese herbal medicine, 1992,15 ( 12): 42

[16] Zhang Guimei, Feng Zuohua, Hao Tianling, et al. Effect of allicin on T cell activation. Pharmacology and clinic of Chinese traditional medicine, 1995,11 ( 1): 26

Clinical trials:

[1] Ji Yu. The clinical experience of Rhubarb and Garlic mixture of 36 cases with acute appendicitis[J]. Chinese Community Doctors 2005, 7 (20) : 73.

[2] Tian YuHong. The clinical observation of “Da Huang Xiao Suan Fang” on chronic appendicitis[J]. Chinese Journal of Rural Medicine and Pharmacy 2005, 12 (10) : 46.

[3] Huang LanTao. The clinical observation of garlic vinegar liquid in the treatment of 31 cases with allergic rhinitis [J]. China’s Naturopathy. 2005, (13) : 26.

[4] Gui ShiYue. The clinical observation of garlic juice in the treatment of 27 cases with bedsore and[J]. China’s Naturopathy, 2000, (4) : 46.

[5] Li YaBin. The clinical observation of “Yin Suan mixture” in the treatment of 54 cases with acute bacterial dysentery[J]. Jilin Journal of Traditional Chinese Medicine, 2001, (4) : 42.

[6] Wang Hao. The clinical observation of mirabilite and garlic on residual empyemata and effusion after abdominal postoperative[J]. Chinese Community Doctors, 2004, 20 (3) : 36.

[毒理学: