[English Name] | Rhizome of Common Curculigo | |
[Chinese Name] | 仙茅 | |
[Pinying Name] | Xianmao | |
[Latin Name] | Rhizoma Curculiginis | |
[Genera] | Amaryllidaceae | |
[Efficacy] | buyao | |
[Pictures] | Plant picture | Drug picture |
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[Alias] | ||
[Source] | ||
[Plant morphology] | ||
[Distribution] | ||
[Gathering and processing] | ||
[Characteristics] | ||
[Ecology] | It grows in grass land which under forest or in barren hillside. | |
[Chemical composition] | The rhizome contains curculigoside A、B, orcinol glucoside, corchiosideA, curculigosaponin A、B、C、D、E、F、K、L、M, curculigine A、B、C, curculigenin A、B、C, curculigol, yuccagenin, 5,7-dimethoxymyricetin-3-O-α-L-xylopyranosyl(4→1)-O-β-D-glucopyranoside, nitrogenous matt: lycorine, N-acetyl-N-hydroxy-2-carbamic acid methylester, 3-acetyl-5-carbomethoxy-2H--3,4,5,6-teTCMLIBahydro-1-oxa-2,3,5,6-teTCMLIBazine, N,N,N',N'-teTCMLIBamethylsuccinamide. It also cntains cycloartenol, β-sitosterol, stigmasterol, henTCMLIBiacontanol, long-chain fatty compounds: 3-methoxy-5-acetyl-31-TCMLIBiTCMLIBiacontene, 21-hydroxyteTCMLIBacontan-20-one, 4-methylheptadecanoic acid, 27-hydroxyTCMLIBiacontan-6-one, 23-hydroxyTCMLIBiacontan-6-one, 23-hydroxyTCMLIBiacontan-6-one, 4-acetyl-2-methoxy-5-methylTCMLIBiacontane, 4-acetyl-2-methoxy-5-methylTCMLIBiacontane, 25-hydroxy-33-methylpentaTCMLIBiacontan-6-one. | |
[Pharmacological activities] |
1. the removal of oxygen free radical Wuqiong’s [1]experiments found that Rhizome of Common Curculigo has good scavenging effects on hydroxyl radical and superoxide radical sca. Zhang Zhendong ’s [2] experiments results show that Rhizome of Common Curculigo has strong effects on hydroxyl radical and diphenylpicrylhydrazyl free radical clearance and iron ion reduction. 2. enhance immune function, As Lakshmi’s [3] experiments reported, the methanol extract of Rhizome of Common Curculigo obviously promotes delayed-type hypersensitivity and cell-mediated immune response and enhances the body immunity. 3. anti-osteoporosis effect By the method of ovariectomized , Cao Dapeng [4] ’s results show that bone mineral content and density of rat was significantly increased after intragastric administration of Rhizome of Common Curculigo extract in the rat model of osteoporosis. 4. nourishing kidney and tonic yang Zhang Mei [5]confirm Rhizome of Common Curculigo has role on nourishing kidney and tonic yang. The effect of its active ingredients may be Rhizome of Common Curculigo A[6]. 5. Liver protection Venukumar [7] demonstrate Rhizome of Common Curculigo has better effect on liver protection. 6. protect the cardiovascular system Cometa[8] found that the total extract of Rhizome of Common Curculigo, pilosidine(butanone monomer compound) can increase blood pressure of anesthesia Wistar rats by dose-dependent. Palazzino [9] found total extract of Rhizome of Common Curculigo, methyl ethyl ketone component monomers can further protect the cardiovascular. 7. hypoglycemic effect Chanhan [10] found that ethanol extracts from Rhizome of Common Curculigo within the concentration from 100 to 200mg/kg, by dose-dependent ,can inhibit elevated blood glucose levels induced by alloxan in diabetic rats. 8. other aqueous extract of Rhizome of Common Curculigo can stimulate bone marrow mesenchymal stem cells of rat , directionally differentiate them into neuron-like cells [11]. |
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[Clinical trial] | 1. The treatment of osteoporosis: WangChangHai et al used western medicinetherapy as control group to treat osteoporosis, with Xianmao and Xianlingpi astreatment group, the results of two groups of patients were all improved bonemineral density, all were effective but no significant difference. Zhang GuiYou made Erxianjiangutang with Xianmao,Xianlingpi and Danggui etal to treat forsenile osteoporosis vertebra waist back pain caused in 65 cases, the 34patients were cured. 27 cases were effective [1,2]. 2. Treatment of mammary gland hyperplasia: CaoJianXi had cured 202 cases of mammary gland hyperplasiapatients with Xianmaoruliuxiaotang, the total effective rate were 92.86%[3,4]. 3. Postmenopausalarthritis: Zhang Meixiang etal had studied the effect of treatment of Postmenopausal arthritis withXianmao fufang as treatment group and diethylstilbestrol as control, the totaleffective rate of the treatmeng group was 83%[5]. |
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[Properties] | Taste: acrid; property: warm; toxic. |
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[Medical and other Uses] | Function: warming kidney to invigorate yang, dispel cold and dehumidify Syndromes to be treated: impotence, incontinence of urine, stomach psychroalgia, waist and knee ache, lower limb Spasm, menopausal syndrome. |
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[Dosage] | Oral administration: decoction, 3 External application: spread on the skin with smashed powder. |
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[Cautions] | Forbid to be used in the patients who with the syndrome of fire excess from Yin deficiency. |
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[Traditional usage] |
1. Impotence, tinnitus 2. Enuresis of the aged 3. Strengthening the musculature and bones, nourishing the vital energy, and improving the eyesight 4. Relieving asthma, tonifying the heart and kidney, and depressing qi 5. Hypertension due to disharmony between Chong and Ren meridians 6. Metrorrhagia in women 7. flat carbuncle-abscess with swelling due to toxic heat 8. Snake bites |
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[Toxicological studies] | ||
[Pharmaceutical preparations] |
1. GuxianTablet: prepared rehmannia root, fortune’s drynaria rhizome, curculigo rhizome, dodder seed, wolfberry fruit,glossy privet fruit, achyranthes root, black seed of soybean, tetrandra root. 2.Can’egongbu Tablet: silk moth(prepared), commoncnidium fruit, curculigo rhizome, desertliving cistanche, epimedium, ginseng, whiteatractylodes rhizome(stir-frying), chinese angelica root, prepared rehmanniaroot, wolfberry fruit, psoralea fruit(processing with salt water), dodderseed(processing with salt water). |
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[References] |
Chemical Composition: [1] Xu Junping, Et Al. Studies On The Chemical Constituents Of Curculigo Orchioides. Chinese Herbal Medicine,1987,18(5):2 [2] Xu Junping, And So On. Curculigo Phenolic Glycosides. Pharmaceutical Journal,1992,27(5):353 [3] Fu Daxu, Ray Guangqing, Cheng Xiaowei Curculigoside C - Curculigo Orchioides Rhizomes New Phenolic Glycoside Constituents Of.Acta Botanica Sinica.2004,26(5):621~ 624 Pharmacological Effect: [1] Wu Qiong, Cheng Xiaowei, Lei Guangqing, Etc. Effect Of Curculigoside On Free Radical Scavenging [J]. The Chinese Journal Of Modern Applied Pharmacy,2007,24(1):6-9 [2] Zhang Zhendong, Wu Lanfang, King Yongshuai, Etc. Study On Antioxidant Activities Of Extracts From Curculigo Orchioides In Vitro [J]. Chinese Journal Of Gerontology,2009,24(19):3201-3202 [3]Lakshmi V, Pandey K, Puri A, Et Al.Immunostimulant Principles From Curculigo Orchiodes[J].J.Ethnopharmacol,2003.89(2-3):181-184 [4] Cao Dapeng. Anti-Osteoporotic Chemical Constituents In Curculigo Orchioides And It’S Quality Evaluation [D]. Changchun: Master Degree Thesis Of Jilin Agricultural University,2008 [5] Zhang Mei, Song Qin. Curculigo Orchioides In Ovariectomized Mice Kidney Yang Effect Study Of Effective Components Of [J]. Sichuan Traditional Chinese Medicine,2005,23(5):22 [6] Zhang Mei, Song Qin, Guo Ping. The Plant In Ovariectomized Mice Kidney Yang Effect Study Of Effective Components In [J]. Sichuan Traditional Chinese Medicine,2006,24(2):22 [7]Venukumar Mr,Latha Ms.Hepatoprotective Effect Of The Methanolic Extract Of Curculigo Orchioides In Ccl4-Treated Male Rates[J].Indian Jpharm,2002,34(4):269-275 [8]Cometa Mf,Palazzino G,Galeffi C,Et Al.Studies On Vasoconstrictor Activity Of Curculigo Pilosa Extracts And Of Its Isolated Compounds[J].Farmaco,2001,56(527):353-356 [9]Palazzino G, Galeffi C,Federici E,Et Al.Benzylbenzoate And Norlignan Glucosides From Curculigo Piosa:Structural Analysis And Invitrovascular Activity[J].Phytochemistry,2000,55(5):411-417 [10]Chauhan Ns,Dixit Vk.Antihy Perglyeeemic Activity Of The Ethanolic Extraet Of Curculigo Orchioides Gaertn[J].Pharmacognosy Magazine,2007,3(12):237-240 [11] Shen Huarui, Lu Arts, Yang Songtao . Chinese Curculigoside On Bone Marrow Stem Cells Into Neuron-Like Cells Induced By Experimental Study [J]. Journal Of Chengdu University Of Traditional Chinese Medicine,2005,12,28(4):8-11 Clinical Trials: [1] Wang Changhai Erxian Decoction In The Treatment Of Osteoporosis In Traditional Chinese Medicine [J]. Shaanxi,1998,19(5):34 [2] Zhang Gui. Erxian Jiangu Decoction In Treating Senile Vertebral Osteoporosis Caused By Lumbar Back Pain Report Of 65 Cases Of [J]. Of Traditional Chinese Medicine,1999,7(2):28-29 [3] Cao Jianxi, Chen Jian. The Plant With Ruliuxiao Decoction In The Treatment Of Breast Hyperplasia : Clinical Observation Of 202 Cases Of [J]. Henan Journal Of Traditional Chinese Medicine,2001,16(1):15-17 [4] Chen Jian, Zhou Yan. Curculigo Ruxiao Decoction In Treating210 Cases Of Hyperplasia Of Mammary Glands [J]. Henan Medicine,2005,25(11):15 [5] Zhang Meixiang, Zhang Xiaozhong. Effects Of Erxian Decoction In Treatment Of Postmenopausal Osteoarthritis In 92cases Of [J]. Modern Journal Of Integrated Traditional And Western Medicine,2008,35(17):5497 Toxicology: [1] Chen Quansheng, And So On. Journal Of Traditional Chinese Medicine,1989,14(10):618 |