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[English Name] Beautyberry leaf
[Chinese Name] 紫珠  
[Pinying Name] Zizhu  
[Latin Name] Callicarpa bodinieri Purplepearl  
[Genera] Verbenaceae
[Efficacy] zhixueyao
[Pictures] Plant picture Drug picture
Plant picture
 
Drug picture
 
[Alias]  
[Source]  
[Plant morphology]  
[Distribution]  
[Gathering and processing]  
[Characteristics]  
[Ecology]     It is tropical plant,prefers warm and moist,is afraid of wind and draught, mean annual temperature between 15 to 25 is suitable climate environment, annual rainfall between 1000 to 1800 millimetres,  red-yellow soil is the best.It grows better in shaded environment. Beautyberry leaf has many coppice shootsdevelop root,is shallow root tree spiece,starts to leaf expansion in March, completely expanses in the beginning of April. The flowers start to germination in the end of May, florescence is a little longer,which is from the beginning of June to the beginning of October,flowering while seed setting.New shoots grow fastly, shoot growth three times a year, respectively for spring shootssummer shoots and autumn shoots,grow 2 to 3 metres tall annually,falls in the end of November. Harvest time is the middle and the end of November.It often mixs with Pinus massonianaCamellia oleifera Moso bambooMangosteen Rhododendron simsii PlanchCamellia chekiagoleoraLitsea cubebaRoot of reedlike sweetcaneLiquidambar formosana and so on.  
[Chemical composition]  
[Pharmacological activities]

1. Callicarpa bodinieri Purplepearl exhibit actions on promoting blood clotting, contracting vessel and increasing platelet number[1-3].

2. Callicarpa bodinieri Purplepearl has the inhibiting effect on the growth of bacteria such as escherichia coli, shigella dysenteriae, staphylococcus aureus, typhoid bacillus, hemolytic streptococcus, pseudomonas aeruginosa and so on[4].

2.

 
[Clinical trial]

1. Bleeding:(1) upper digestive tract hemorrhage 305 cases were treated with zizhu(beautyberry leaf) for frozen lavage. Among duodenal ulcer of 190 cases, gastric ulcer of 32 cases, gastric anastomotic ulcer of 7 cases, stress ulcer of 5 cases ,chronic gastritis and duodenitis of 42 cases, gastric mucosa prolapse of 4 cases, unknown causes of25 cases. Results showed that in the mild symptoms (131 cases),125 cases were cured, 1 case was effective, 5 cases were invalid and the average time for stool occult blood tests turning negative was 3.6d. In the Moderate (114 cases), 109 cases were cured, 1 case was obvious effective, 2 cases were effective, 2 cases were invalid, the average time for stool occult blood tests turning negative was 4.3d. In the Severe (60 cases), 50 cases were cured, 2 cases were obvious effective, 1 cases were effective, 7 cases were invalid, the average time for stool occult blood tests turning negative was 4.7d.The total cure rate was 93.1%, the efficiency was 95.4% [1]. 20 cases of esophageal variceal bleeding caused by cirrhotic portal hypertension after the failure of three tube compression hemostasis and posterior pituitary protamine hemostatic were treated with zizhu(beautyberry leaf) 60g, fried thick, injected into stomach. 19 cases were treated by gastric perfusion, the other 1 case by oral.Results showed that 17 cases were stopped bleeding in 24h, accounting for 85%;3 cases were invalid, accounting for 15%[2].bleeding of operation: bleeding after tooth extraction: 500 cases (800 teeth)were Observed, After tooth extraction, zicao powder sprinkled wound, the efficient rate was 99% [3]. bleeding during operation: 53 cases were treated with zicao water extractives , made into absorbable hemostatic gauze and used in clinical departments, of operation process of hemostasis. Results showed that large-scale operation of 35 cases, medium-sized operation of 12 cases, small-sized operation of 6 cases. It can stopped bleeding subcutaneous tissue in 1~2min, basically without hemostatic forceps Where a vessel diameter less than 0.5mm [4]. bleeding and pain after tonsillectomy: zizhu(beautyberry leaf) 1000g, meipian5g, juhua(Chrysanthemum)250g, added sesame oil 1000ml. After tonsillectomy, zimeiju oil agent was putted in the tonsillar fossa wounds. In 58 cases, 41 cases were excellent effective [5].Functional uterine bleeding : 40 cases were treated with zizhu(beautyberry leaf), direngen(Melastoma dode candrum Lour), fangtianhua(Urena procumbens) each30g and took it in first days of menses. 1 agent Daily, took 3 agents continually, in order to consolidate the curative effect, it can take 3~6 agent. Results showed that 33 cases were followed up, of which 16 cases were cured, 14 cases were effective, 3 cases ineffective, it took at least 3 agent to the 20 agent [6].

2. Hemorrhoid: 614 cases of hemorrhoid, mixed hemorrhoid and annular hemorrhoid were treated with Zizhu (beautyberry leaf) kuzhi injection (zichucao (beautyberry leaf) 250g, alum 3g, procaine 1~2g) for injection .Results showed that 596 cases were cured, the curative rate was 97.1%. The curative rate of internal hemorrhoid, mixed hemorrhoids and annular hemorrhoid was 99.6%, 95.1%, 93.2% respectively.92.53% of the patients cured in one time [7].

3.Burn20 cases were treated with Zizhu(beautyberry leaf) grinded into powder for external use. 1 time daily or alternate-day. Results showed that the patients of the superficial II degree burn scabbed after 2~3 times and scabbed off after 2~3days; the patients of the deep second degree burn scabbed after 3~7 times and scabbed off after 2~5days. There was no scar after healing [8].

4.Gynecological inflammation: 78 cases of cervicitis ,Vaginitis( including general vaginitisbeads bacterium vaginitis ) were treated with zizhu(beautyberry leaf) . Results showed that 38 cases were cured, 33 cases improved, the effective rate was 91% [9].

 
[Properties]  
[Medical and other Uses]  
[Dosage]  
[Cautions]  
[Traditional usage]

1Hemoptysis

2Hemoptysis induced by pulmonary tuberculosis, hemorrhage due to gastroduodenal ulcer

3Bleeding caused by gastric ulcer

4Bleeding from aperture or subcutaneous tissue

5Unstopped bleeding after tooth extraction

6Functional metrorrhagia

7Thrombocytic purpura

8Bleeding caused by trauma

9Internal injury bleeding

10Swelling and pain due to sprain

11Upper respiratory tract infection, tonsillitis, pneumonia, bronchitis

12Reddish eyes

13Carbuncle, pharyngitis, snake bite, rabies

14Vaginitis, cervicitis

15Scrofula, goiter

 

 
[Toxicological studies]  
[Pharmaceutical preparations]  
[References] Pharmacological actions:

[1] Promotion group of Chinese Herbs of Hangzhou first hospital. The mechanism of Callicarpa bodinieri Purplepearl on hemostatic and clinical application. 1971:3.

[2] Chinese people's Liberation Army 459 hospital. Selections of medicine and health research experience exchange materials. 1972:156.

[3] research data of Hunan medical hospital, 1976.(3):68.

[4] Chinese people's Liberation Army 468 hospital. The species, cultivation, preparation and application of Callicarpa bodinieri Purplepearl. 1970:2.
clinical test:

[1] Qiu hemingetc.China Journal of Chinese Materia Medica1988.13(8):48.

[2] Zhang zhihong.Jiangsu Medical Journal.1978. (3):9.

[3] Dentistry in people's hospital, Haikou city, Guangdong province .New Medicine. 1971(10):45.

[4] The first hospital in fuzhou.Chinese herbal medicine communication.1971.(1):21.

[5] Han wenxian.Chinese Journal of Integrative Medicine.1986.(3):305.

[6] Herbal room in health center, yuhu area, wenchen town, Zhejiang province .Chinese Journal for Clinicians.1975. (2):29(79).

[7] Military fuzhou general hospital.People Military Surgeon.1975.(2):57.

[8] Wang ligang.Chinese Journal for Clinicians.1975.(4):10(176).

[9] Hainan area of Guangdong people’s hospital of gynecology.New Medicine. 1971. (6.7):45.