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[English Name] Copperleaf Herb
[Chinese Name] 铁苋菜  
[Pinying Name] Tiexiancai  
[Latin Name] Acalyphae Australis Herba  
[Genera] Euphorbiaceae
[Efficacy] Antipyretic drug
[Pictures] Plant picture Drug picture
Plant picture
 
Drug picture
 
[Alias]  
[Source]  
[Plant morphology]  
[Distribution]  
[Gathering and processing]  
[Characteristics]  
[Ecology]     It mostly grows in middle and lower basin of the Yellow River basin and all over south of the Yangtze river,and wildernesswetter area beside road.  
[Chemical composition]  
[Pharmacological activities]

1 Antibacterial capability:Escherichia coli, Staphylococcus aureas, Salmonellacholerae-suis, have some Certain inhibition effect, particularly have the bestinhibition effect of Staphylococcus aureas [1,2]; the effect of extracted waterwas 60 % better than alcohol extraction water. The inhibition concentration was62.50 mg·mL-1, 15.62 mg·mL-1, 125.00 mg·mL-1expectively [3]. So it is considered the extraction of ethyl acetate is thefrom Acalypha australis L. is more effective concentration of the effect site[4]. We take advantage of the organic solvent, extraction technique, divide theamaranth iron extraction water having the better antibiosis action in to fourpolarity parts of petroleum benzine, chloroform, acetoacetate, and n-butanol[5].

2 Anti-inflammatory: Acalypha decoction inprevention and treatment of trinitrobenzene sulfonic acid induced ulcerativecolitis in rats [6]. The index SOD andGSH-Px increased and MDA reduced significantly in high-and moderate-copperleafdecoction groups compared with the model group [7]. The production of NO theactivity of iNOS reduced significantly in high-and moderate-copperleafdecoction groups compared with the model group [8]. RT-PCR results demonstratedthat the expression of iNOS mRNA was significantly inhibited in TNBS-inducedulcerative colitis rats after being treated with moderate-dosage copperleaf.Acalypha australis L. has antioxidative and antinitrosative effects which isprobably one of the mechanism of copperleaf for treating UC [9].

3 Antidiarrhealeffect: Acalypha can inhibit salivationand diarrhea, the effective ingredients of diarrhoea, in addition to the gallicacid, geraniin, caffeoylmalic acid should also be regarded as effectiveingredients [9]

4 Hemostatic: Acalypha promoted platelet adhesion and accumulation, beneficial to theformation of bthrombus, decrease the action of antithrombin, increase thecontent ofα2-MG,reduce the fibrinolysis activity and promotethe blood coagulation. Thehemostatic mechenism was related to increasing plateletcount, promoting itsfunction, inhibiting fibrinolysis system [10].

5 Antiasthmatic Effects: Gallic acid extracted Acalypha austrolis L. significantly antagonizedbronchoconstriction, and the efficacy can be maintained for 120 minutes [11].

 
[Clinical trial]

1. Bacterium dysentery enteritis: 100g250g fresh herbs or 25100g dry herbs were boiled with water. Patients were given the decoction 2~3 times a day, 57 days as one course of treatment. The decoction could also be used as enema. Many patients' condition had improved after two days treatment, most of the patients' stool exam were conversed to negative within 4~5 days, the cure rate was over 95%.

2. Amebic dysentery: 100200g herbs were made decoction, patient was taken twice a day, 510 days as one course of treatment. 27 cases of patients were treated with the decoction, symptoms were disappeared within six days, stool exam were conversed within nine days. There also reports showed that 100 case of patients were treated with the herbs and all had significant effect.

3. Ileotyphus: 100g fresh herbs were make 200ml decoctions, patient were taken twice a day. Xixoshanhu were also given help bring down the fever.

4. Upper gastrointestinal hemorrhage: 105 cases of patients were treated with Xueyu tablet, 3~4 times a day, 4 tablet for each time. Results: 101 cases stopped hematemesis and fecal occult blood test conversed negative, the effective rate was 96.1%.

 
[Properties]  
[Medical and other Uses]  
[Dosage]  
[Cautions]  
[Traditional usage]

1.       Poisonous snake bite

2.       Amebic dysentery

3.       Dysentery , enteritis

4.  Fistula

5.  Hematemesis, hematochezia, and hematuria

6.  Malaria

7.  Hypogalactia

8.  Infantile malnutrition

9.  Pediatric dyspeptic diarrhea

10. Pediatric abdominal distension, swelling of testis

 
[Toxicological studies]  
[Pharmaceutical preparations]  
[References]

Clinical trial:

[1] Nanjing University of Traditional Chinese Medicine. Chinese medicine dictionary (Rudin).No.2. Shanghai Scientific and Technical Publishers,2006:2601.