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[English Name] Chinese Arborvitae Branch and Leaf
[Chinese Name] 侧柏叶  
[Pinying Name] Cebaiye  
[Latin Name] Platycladi Cacumen  
[Genera] Cupressaceae
[Efficacy] zhixueyao
[Pictures] Plant picture Drug picture
Plant picture
 
Drug picture
 
[Alias]  
[Source]  
[Plant morphology]  
[Distribution]  
[Gathering and processing]  
[Characteristics]  
[Ecology] It grows in moist and fertile land,also in lime rock land.  
[Chemical composition]

Theleave contains volatile oil: α-thujone, thujene,fenchone, pinene, caryophyllene; stearic acid, palmitic acid, lauric acid, myristicacid, linoleic acid, oleic acid, capric acid;

Flavonoid: cupressuflavone,apigenin, quercitrin, kaempferol-7-O-glucoside, quercetin-7-O-rhamnoside, myricetin-3-O-α-L-rhamnoside,myricetin, hinokiflavone, amentoflavone;

Other: 10-nonacosanol,β-sitosterol, condensed tannin, deoxypodophyllotoxin,isopimaric acid[1];

The woods containsvolatileoil: α-cedrene, β-edrene, widdrol, α-cuparenol, β-cuparenol,γ-cuparenol, cuparenol, α-isocuparenol, α-biotol, β-biotol, β-isobiotol, curcumenether, thujopsene, thujopsadiene,α-cedrene, β-cedrene, β-chamigrene, α-cuprenene, γ-cuprenene, α-curcumene,dehydro-α-curcumene, cuparene, α-cuparenone, β-cuparenone, mayurone, widdrol α-exoxide,monoterpenoidAcid (4%)[2].

 
[Pharmacological activities]

1. Ethanol extraction and total flavonoids isolated from Patycladi Cacumen have an anti-inflammatory effect[1,2].
2. The volatile constituents from the leaves, seed and seed capsule of Platycladus orentalis have an inhibiting effect on human lung cancer cell line NCI-H460[3].
3. The ethanol extraction, petrol ether extraction and alcohol sediment isolated from Platycladi Cacumen have the significant effect on eliminating phlegm and relieving cough[4-7].

4. Relieving asthma: ethyl acetate extraction isolated from Platycladi Cacumen could relax isolated smooth muscle of mice and guinea pigs[4,5].

5. The water extract from Platycladi Cacumen could obviously shorten the bleeding time of mouse and clotting time of rabbit[10-16].

6. Sedative effect: The water extract from Platycladi Cacumen could obviously reduce the time of spontaneous activity of mouse and prolong the sleeping time induced by pentobarbital sodium[17].

7. The water extract from Platycladi Cacumen could mildly reduce blood pressure of cat and has  certain vessel-dilating effect on isolated perfused rabbit ear vessels[5,7].

8. antibacterial action: The water extract from Platycladi Cacumen have the inhibiting effect on the growth of bacteria such as staphylococcus aureus, Catarrhal coccus, shigella dysenteriae, typhoid bacillus, Corynebacterium diphtheriae, streptococcus, Bacillus anthracis and so on[5,7].


 
[Clinical trial]

1. Recurrent aphthous ulcers: 160 cases were randomly divided into A and B group. Two group used alternately the cebaiye(Chinese Arborvitae Branch and Leaf) paste and Bingpengsan in the 2 episode namely in the first episode, group B treated with Bingpengsan , group A with cebaiye(Chinese Arborvitae Branch and Leaf) paste, in the second episode , group A with Bingpengsan, group B with cebaiye(Chinese Arborvitae Branch and Leaf) paste. 4 times a day, did not use other drugs. Results showed that the first episode : in group A (80cases),40 cases were cured, 25 cases were markedly effective, 13 cases effective, the total effective rate was 97.5%; in group B ( 80 cases), 14 cases were cured, 21 cases were markedly effective, 32 cases effective, the total efficiency was 83.75%. The second episode: in group A (80cases), 18 cases were cured, 20 cases were markedly effective, 31 cases effective, the total effective rate was 86.25%; in group B (80cases), 44 cases were cured, 25 cases were markedly effective, 10 cases effective, the total efficiency was 98.75%[1].

2.Herpes zoster: fresh cebaiye(Chinese Arborvitae Branch and Leaf) mash mixed with egg white paste, coated on the affected area, approximately 1cm thick. 2 times daily. Results showed that 18 cases were cured, 12 cases were cured in 3 ~ 6 days, 6 cases were cured in 7 ~ 8days; 2 cases were markedly effective. The efficiency was 95.2%[2].

3. Burns : Compound cebai carbon ointment in Treating 57 cases of burn, Results showed that 57 cases were cured, the curative time is the shortest for 5 days, the longest 18, the curative rate was 100%[3].

4.cervical erosion : cebai powder for external use in treating 608 cases of cervical erosion. Results showed that all the cases were all effective, the curative rates were respectively 73.85%, 93.59% and 100% after 2, 3, and 6 months of treatment. the curative rates of light, medium,severe degree were respectively 96.7%、80.35and0 after 2 months of treatment; the curative rates of light, medium,severe degree were respectively 100%, 95.09% and 75% after 3 months of treatment; all cases were cured after 6 months of treatment [4].

5. sweat herpes: 20 cases were treated with cebaiye(Chinese Arborvitae Branch and Leaf) Decoction ( cebaiye(Chinese Arborvitae Branch and Leaf)30g, digupi(cortex lycii radicis) 20g, yinhua((Honeysuckle Flower)20g, tougucao (phryma leptostachya)20g , aiye(folium artemisiae argyi )20g, gancao (radix glycyrrhizae) 20g.If had Itch ,added baixianpi(Dictamni Cortex )20g, Fangfeng(radix sileris)20g;If had more sweat,added mingfang and gegen(Lobed Kudzuvine Root)20g ) .5 agent as 1 courses. Results showed that 14 cases were cured, 4 cases were effective, and the total efficiency was 90%. Follow up of 2 years, the cured patients had no recurrence, 1 patient had relapsed in the 4 effective cases [5].

 
[Properties]  
[Medical and other Uses]  
[Dosage]  
[Cautions]  
[Traditional usage]

1.Epidemicmumps

2. Internalabscess

3. Nonhealingfistula with pain before suppuration

4. Mastitis

5. Coldsymdroms with incessant hematemesis

6. Hematemesisand hemoptysis induced by accumulated heat in blood

7. Pyelonephritis,hematuria

8. Arthritisinduced by wind-bi

9. Chronichematodiarrhea, severe pain in small intestine

10. Parasiticdysentery, stools with dark blood or blue pus

11. Unstoppedhemafecia caused by wind toxin in large intestine

12. Hemorrhoidalhamorrhage, incessant hemafecia and dysentery caused by heavy drinking

13. Perianalabscess with pain and sometimes with bloody pus

14. Postartumhemorrhage

15. Pertussis

 

 
[Toxicological studies]  
[Pharmaceutical preparations]  
[References]

Pharmacological actions:

[1] Liang Tong, Qin Yan-mei, Ding Hang. Anti-inflammatory effects of total flavonoids isolated from Platycladus orientalis. Journal of Shenyang Pharmaceutical University, 2004,21(4):301.

[2] Liang Tong, Qin Yan-mei,  Liang Nian-Ci. Study on the Anti-inflammatory Effect of Biota orientalis. Journal of China Pharmaceutical University, 2001,32(3):224.

[3] Jiang Ji-hong, Li Xiao-chu, Gao Xue-qin. Volatile Constituents from Platycladus orentalis and Their Antitumor Activities. Forest Research, 2006,19(3):311.

[4] Chronic Bronchitis Prevention Research Group of Zhejiang Materia Medica Institute. Compilation of Scientific Research Data, 1973:175.

[5] Chronic Bronchitis Prevention Research Group of Zhejiang Materia Medica Institute. Compilation of Scientific Research Data, 1972:130.

[6] Chronic Bronchitis Prevention Pharmacology group of the Fourth Military Medical University. Science and Technology Information, 1975,(6):1.

[7] Chronic Bronchitis Prevention Pharmacology group of the Fourth Military Medical University. Science and Technology Information, 1972,(3):21.

[8] Chronic Bronchitis Prevention Pharmacology group of the Fourth Military Medical University. Science and Technology Information, 1973,(5):10.

[9] Pharmacological research of Hebei new medical university. New medical research, 1972,(3):2.

[10]Xu Zhen-wen, Bao shi-lan, Zhao Juan-juan. Study on the Hemostatic composition of Platycladus Orientalis. Bulletin of chinese materia medica, 1983,8(02):30

[11]Pharmacology laboratory of Shandong Chinese Medicine Institute. Traditional Chinese medicine research material,1965,(3):48.

[12]KosugeT, Ishida H, Satoh T. Studies on antihemorrhagic substances in herbs classifiedas hemostatics in Chinese medicine. V. On antihemorrhagic principle in Biotaorientalis (L.) Endl. ChemPharm Bull (Tokyo).1985 Jan;33(1):206-209.

[13]Sun Wen-ji, Sha Zhen-fang, Wu Jing. Determination on Quercitrin in Platycladus Orientalis with HPLC. Acta Pharmaceutica Sinica, 1987,22(05):385.

[14]Jiang Ji-yang, Li Tong-yong, Li Cun-xin. Study on processing of Platycladus Orientalis. Bulletin of chinese materia medica, 1987,12(11):660.

[15]Xu Chu-jiang.science of processing Chinese materia medica. Shanghai Science and Technology Press,1985:62.

[16]Yan Ling-xiao, Shi Sheng-xiang, Sun Wen-ji. Different Processing of Platycladus Orientalis hemostatic effect. Journal of Chinese Medicinal Materials,1989,12(7):22.

[17]Pintn Scognamiglia W. C A,1969, 70:76275j

[18]Guo Jun,Shan Ju-sheng, Yan Bang-shou. Effect of 291 kinds of Chinese medicine on Anti-tubercle bacillus. Chinese Journal of Antituberculosis,1964,5(3):481.

[19] Shandong Platycladus Orientalis Cooperative Research Group. Medicine Communication,1975,(1):1.

[20]Guiyang TB Prevention and Treatment Hospital. Chinese Journal of Antituberculosis,1959,2(6):37.

[21] Medicine Research Institute of Chinese Medicine virus group. Chinese medicine treatment of bronchitis in children. Journal of New medical,1973, (1):26.

[22]Jia Yuan-yin, Yao Qian-yuan, Xie Hong-xia. study on V crystal in Platycladus Orientalis metabolism in animals. Shandong Pharmaceutical Industry, 1989,8(3):17.

clinical test:

[1] Wang yongshengYang lijunGuang caiqietcclinical observation On Recurrent aphthous ulcers treated with cebaiye(Chinese Arborvitae Branch and Leaf) pasteJilin Journal of Traditional Chinese Medicine200222(3):27

[2] Wang zijunHerpes zoster treated with cebaiye(Chinese Arborvitae Branch and Leaf)Chinese medicine research magazine20044(3):257

[3] Cheng shengdaBurns treated with Compound cebai carbon ointment in 57 casesJournal of External Therapy of Traditional Chinese Medicine19962:30

[4] Xiao yingChen yancervical erosion treated with cebai powder for external use 608 casesChinese Journal of Practical Meicine200532(13):1315

[5] Wang xiaoyunZhang chengjiesweat herpes treated with cebaiye(Chinese Arborvitae Branch and Leaf) Decoction in 20casesShaxi Journal of Traditional Chinese Medicine200829(5):568569