1. Antibiosis: Calvatia lilacina water extract and fermentation broth show antibiosis activity. Calvatia gigantea possess antibiosis on staphylococcus aureus, pneumococcus, aeruginosus bacillus and fungal[1-4]. Ergosterol peroxide possess antimycobacterial activity[5].

2. Antiinflammatory: Lasiosphaera fenzlii reich show anti-inflammatory activity on swelling of ear mice[6].

3.Anticancer: Calvatia gigantean polysaccharides inhibit neoplastic cell S180 proliferation[7]. The homolog of ergosterol show cytotoxicity on MCF-7, Walker256, HT-29, Hela229, Hep3B and AGS cell[8,9]. Calcaelin and peptide like ubiquitin show cytotoxicity on breast cancer cell[10,11].

4. Hemostasis: Puff-ball powder and spores show mechanical hemostasis activity on bleed local[3,12,13].

5. Cough Relieving: lasiosphaera fenzlii reich prolong cough latency period on guinea pigs cough model induced by mechanical irritation[6].

6.Insect Disinfestation: Earth balls ligroin extraction show insect disinfestationc activity on 3rd day old armyworm[14].

7.Effect on Allergic Reaction: Puff-ball spores play importance role in allergic reaction on organum respiratorium induced by fungal allergens in air[15].

1. Cough: 276 cases of patients were divided in to treatment group and control group. Treatment group were treated with prescription consisted of Mabo, Yinhua, Lianqiao, Niubangzi, Shegan, Guoloupi, Qianhu, Jiegeng, Xingren, etc. these herbs were boiled with water, taken one prescription a day. Results: effective rate of treatment group was 92% and 65.4% for control group, significant difference was obtained when compared each other(P＜0.01)^[1].

2. Gastric ulcer: 20g of Mabo and Zhebeimu, 30g of Fenghuangyi and Yuhudie and 15g of Xueyutan and Hupo were weighted and made became powder, 30 cases of patients were treated these drugs three times a day before meals. Results: 25 cases were cured(83％), three cases' condition had improved(10％), two cases were invalid(7％) ^[2-3].

3. Tinea pedis: 100 cases of patients were treated with Mabo powder for external application. The overall effective rate of treatment group was 94.4％, control group was 63.6％, significant difference was obtained when compared each other(P<0.05)^[4].

4. Epistaxis: thin cotton piece were dipped into Hemostasis No.1(consist of Mabo and Dahuang) and applied on the nasal mucosal bleeding or erosion, 67 cases of patients were treated. Results: 59 cases were stop bleeding after first applicaton, five cases stop bleeding after second application and the symptoms of contrafluxion and hemangiectasis disappeared. 17 cases of nasal local bleeding were stopped after 1~3 weeks' treatment^[5].

Taste: pungent; property: neural; belong to lung channel.

Function: clearing away lung-heat and relieving sore-throat, detoxification and arresting bleeding.

Syndromes to be treated: Sore throat, cough, aphonia, vomiting, unhealing ulcer.

Oral administration: decoction, 1.5～6g, decoct in packet , or used in pill and powder.

Topical application: in right amount, smashed and smear on the skin, or used as insufflation of powder drug.

Forbid to be used in the patients of cold -volt lung cough and aphonia.

Pharmacologic Actions:

[1]Harnaou. J Antibiot,1975, 28(1):87.

[2]Gasco A. TetraLett,1974,(38):3431.

[3] Nanking college of pharmacy 《Chinese herbology》drafting group. Chinese herbology(Vol 2) 1st edition. Nanking: Jiangsu People’s Publishing House, 1976:21

[4] Sun Juying, Guo Chaohui.Journal of Chinese Medicinal Materials, 1994,17(4):37．

[5]CharlesL.Planta Medica, 1999,65:732.

[6] Zuo Wenying, Shang Mengkun, Chuai Xingui. Journal of Henan University(Medical Science), 2004,(3):65．

[7] Meng Yanfa, Yang Guoling, Zhou Xiufang, et al. Journal of Lanzhou University(Medical Sciences), 1990,26(2):99．

[8]Kirsti Kahlos. Planta Medica, 1989,55:389.

[9]Wi YongLee. Bul1 Korean Chem Soc, 2005,26(9):1464.

[10]Ng T B.P1anta Med, 2003,69(3):212.

[11]Lam Y W. Biochemicaland Biophysical Research Communieations, 2001,289(3):744.

[12] Qiu Chenbo. Traditional Chinese Medicine new edition. Shanghai: Qianqingtang Publishing House, 1955:200.

[13] Jiang Zhonghai. Plants, 1990,10(01):19．

[14] Wei Yan, Gao Jinming, Hao Shuanghong, et al. Acta Botanica Boreali-Occidentalia, 2005,25(2):382．

[15]Geier M. J Allergy Clin Immunol, 2000,106:92.

[5]Zhang Hong．Local Application of Lycoperdon bovista L. in treatment of nasal hemorrhage．Chinese Journal of Otorhinolaryngology,1965,(1):7．