| [English Name] | Indian Pokwees Root | |
| [Chinese Name] | 商陆 | |
| [Pinying Name] | Shanglu | |
| [Latin Name] | Phytolaccae Radix | |
| [Genera] | Phytolaecaceae | |
| [Efficacy] | xiexiayao | |
| [Pictures] | Plant picture | Drug picture |
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| [Plant morphology] | ||
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| [Characteristics] | ||
| [Ecology] | It grows in open forest beside road、road side and dankness beside house,or is cultivated in the garden.It prefers warm and moist climate,resistants to cold. Growth optimal temperature is about 14 to |
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| [Chemical composition] | ||
| [Pharmacological activities] |
1. Variously processed Phytolacca exhibit diuretic actions[1-3]; Esculentoside A possesses effects of reducing the urinary protein excretion, so it can protect renal function and inhibit the proliferation process of glomerular mesangium and delay the progress of glomerulosclerosis[4-7].2. The experiments showed that Esculentoside A suppressed acute or chronic inflammation strikingly in animal models[8]． 3. Pokeweed antiviral protein isolated from Phytolacca could efficiently inhibit HCV replication in the HepG2 cell model, and block up adsorption of coxsackie virus B3 to host cells[9,10]. 4. Phytolacca acinosa polysaccharides Ⅰ extracted from Phytolacca acinosa Roxb could augment immunologic function in vitro and in vivo, it enhanced splenic lymphocyte proliferation and IL-2 production[11]. 5. Phytolacca acinosa Roxb also exhibits other pharmacological actions such as anti-tumor, treating gastric ulcer, killing oncomelania and so on. |
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| [Clinical trial] | Hepatocirrhosis ascites：the control group were treated on the basis of the shanglu(Indian Pokwees Root) (shanglu(Indian Pokwees Root) mixed fresh shengjiang(Fresh Ginger) ,made into paste,covered on navel ).14 days for 1 course. The control group were treated diuretics, triamterene, complement the human albumin and hepatoprotective and other therapy based on low salt, high protein diet and nutrition support therapy, 14 for 1 courses.Rusults showed that in the treatment group (30 cases) ,21 cases were markedly effective , 7 cases were effective, 2 cases were invalid, the total effective rate was 93.3%; in the control group(30cases), 16 cases were markedly effective, 7 cases were effective, 7 cases were invalid, the total effective rate was 76.7%, two groups had significantly difference ( P>0.01 ) [1] . |
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| [Traditional usage] |
1. Varied pyogenic infections 2. Hard carbuncle like stone without pus 3. Wound and injuries 4. Scrofula 5. Peptic ulcer 6. A cord-like lump in the abdomen without improving, still as hard as stone of hypochondriac pain 7. Swollen and full water retention 8. leg edema due to qi stagnation 9. Postpartum blood clot attacking the heart from time to time and unbearable |
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| [References] |
Pharmacological actions: [1]Masuzawa H. C A, 1943,37:1772. [2] Yuan Si-tong, Wang Zhu-ju, Cheng Ming. Advance of Phytolaccae Radix. Journal of Chinese Medicinal Materials, 1991,14(01):46-48. [3] Zha Wen-qing, Wang Xiao-tao, Yuan Si-tong. Effects of Processing on Toxicity and Pharmacological Action of Phytolacca Acinosa Roxb. Journal of [4] ZHU Yong-jun, ZHANG Ke-fei, GUO Ming-hao, et al. The effect of phytolaccae on the expression of apoptotic mediators Bcl-2, Bax in glomeruli in adriamycin-induced glomerulosclerosis rats. Medical Information (Section of Operative Surgery), 2008,21(11): 967-970. [5] PANG Jun, ZHANG Ke-fei, YU Wu-zhong, et al. Effect of Phytolaccae on Adriamicin-induced Nephropathy Rats. Chinese Journal of Integrated Traditional and Western Nephrology, 2008,9(3):220-224. [6] Zha Wen-qing, Wang Xiao-tao, Yuan Si-tong. Effect of Esculentoside A on the expression of TGF-β [7] ZHANG Liang, ZHANG Ke-fei, WU Xiong-fei. Observation of Therapeutical Effects of Esculentoside A on Rats with MsPGN Induced by Anti-Thy1. Chinese Journal of Integrated Traditional and Western Nephrology, 2008,9(6):506-508. [8] ZHENG Qin-Yue， [9] CHEN Rui-lie，LIN Shao-rui，LI Yi-xuan，et al. Influence of Pokeweed antiviral protein on hepatitis C virus replication in an infection cell model. Chinese Journal of Integrated Traditional and Western Medicine on Liver Diseases, 2006,16(4):226-228. [10] XIE Ni, CHI Xiao-xia, YUAN Jian-hui, et al. Study on Anti-coxsackie Virus Effect of Phytolacca Acinosa Protein Injection in Vitro. Lingnan Journal of Emergency Medicine, 2007,12(02):116-118. [11] HB Wang, QY Zheng, DW Ju, et al. Effects of Phytolacca Acinosa Polysaccharide on Splenic Lymphocyte Proliferation and Cytokine Secretion from Splenic Lymphocyte and Macrophage. Acta Pharmaceutica Sinica, 1993,28(10):732 -737. [12]Dont P B. J National Cancer Institute, 1971,46(4):763. [13] Liu Chun-yu, Wu Wen-qian, Tang Li-hua, et al. Effect of Esculentoside on treating gastric ulcer. Chinese Wild Plant Resources, 1998,17(4):56-58. [14] Li Gui-ling, Feng Qing, Wang Xue-hai, et al. Effect of Esculentoside on killing oncomelania. Chin J Chin Mat Med, 1998,23(5):42. |
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