| [English Name] | Combined Spicebush Root | |
| [Chinese Name] | 乌药 | |
| [Pinying Name] | Wuyao | |
| [Latin Name] | Radix Linderae | |
| [Genera] | Lauraceae | |
| [Efficacy] | Qi-regulating drug | |
| [Pictures] | Plant picture | Drug picture |
|
|
|
| [Alias] | ||
| [Source] | ||
| [Plant morphology] | ||
| [Distribution] | ||
| [Gathering and processing] | ||
| [Characteristics] | ||
| [Ecology] | It grows in the hillside exposed the sun 、valley or open forest bushes. | |
| [Chemical composition] | ||
| [Pharmacological activities] |
1. Anti-bacterial and anti-virus: simultaneous drug delivery and therapeutic administration of Aggregata water extract in primary human embryo musculocutaneous monolayer cells show efficient virus inhibition [1]. Liquid with 20% aggregata can significantly inhibit the respiratory cooperation syncytial virus, the Kesa Ji B1, B3, B4 virus and all the suppression index are four pairs of number, aggregata is a highly efficient antiviral drug [2].The aggregata water and alcohol extract significantly inhibit the herpes simplex virus, are also effective drugs [3]. Aggregata inhibit Staphylococcus aureus, alpha hemolytic streptococcus, Salmonella typhi, Proteus mirabilis, Pseudomonas aeruginosa, Escherichia coli [4].
2. The impact on the digestive system: aggregata as a dual role of excitation and inhibition on gastrointestinal smooth muscle, and can increase the secretion of digestive juices [5]. Aggregata water and alcohol extract can reduce the residual rate in mouse methyl orange stomach, 20g/kg dose can increase the end-advance rate of small intestine carbon in mouse, a significant inhibitory effect on isolated rabbit intestinal smooth muscle motility, and against intestinal muscle induced by acetylcholine, histamine phosphate, barium chloride [6], also against the abdominal pain [7] in clinical application of rhubarb. Aggregata decoction can significantly increase the rabbit gastric electrical amplitude, excite and enhance the gastric motility rhythm[8]; it can also inhibit the formation of ulcers, antagonize the ethanol-induced cell damage, and has a cytoprotective effect, this protection function of aggregata related to nerve function [9].
3. The role of the cardiovascular system: aggregata can excite cardiac, its volatile oil orally can excite myocardial, accelerate the return circulation, boost and sweating, also excite the cerebral cortex, promote respiration, partially coated can expand blood vessels, accelerate blood circulation, ease the pain of compound muscle spasm [4].
4. Other: aggregata root alcohol extract 1×104 g has anti-histamine effection on guinea pig tracheal [10]. The aggregata powder can significantly shorten the recalcification time of rabbit plasma, and promote blood clotting [11]. Aggregata also has antithrombin effect [12]. Aggregata obviously inhibit murine sarcoma S180 [13]. Furan sesquiterpene components of aggregata root have a preventive effect on experimental liver injury, the components have a preventive effect on aspartate aminotransferase (AST), Elevated alanine aminotransferase caused by carbon tetrachloride, it has a strong inhibitory effect on elevated serum transaminases, AST increase caused by ethionine, and can protect the liver from fatty infiltration [14]. Aggregata water, alcohol extract has strong analgesic, anti-inflammatory effect, its anti-inflammatory activity on the n-butanol part of the analgesic is the strongest [15]. The aggregata total alkaloids (TARL) significantly inhibit rat secondary paw swelling, increase the body weight of rats, but only show inhibition on the primary foot extension swelling; in vitro, TARL concentration-dependent inhibit the mouse spleen lymphocyte proliferation caused by concanavalin A and inhibit mouse peritoneal macrophages to release nitric oxide and white interleukin-I induced by lipopolysaccharide [16].
|
|
| [Clinical trial] | ||
| [Properties] | ||
| [Medical and other Uses] | ||
| [Dosage] | ||
| [Cautions] | ||
| [Traditional usage] |
1. Chronic rashes and ulcers 2. Traumatic injuries especially on the back) 3. Hoarseness 4. Headache due to qi-syncope in men, or due to excessive qi or postpartum in women 5. Shortness of breath, depression and unwilling to eat due to emotional injuries 6. Stabbing pain in the chest and abdomen: regulating and smoothing the qi of upper jiao and middle jiao. 7. Asthma 8. Uninhibited and frequent urination, gonorrhea or other syndrome cause by deficiency cold in kidney meridian 9. Unbearable hernia pain 10. Irregular menstruation with red or turbid color, and intermittent periods in women, as well as depression of heart and diagram, distention and dropping pain in abdomen |
|
| [Toxicological studies] | ||
| [Pharmaceutical preparations] | ||
| [References] |
化学成分： [1]State Administration of traditional Chinese medicine in Chinese materia medica editorial board. " " Chinese materia medica. Shanghai: Shanghai science and Technology Press, 1999,7:56 ( total 1642). [2] Wu Zhengyi, Xinhua materia medica outline (volume one) . Shanghai science and Technology Press, 1988: 84 [3] Du Zhiqian, Xia Hualing, E Haicho, et al. The chemical constituents of volatile oil from Radix Linderae GC-MS analysis. Chinese herbal medicine, 2003,34 ( 4): 308 [4] Dong Yan, Liu Hongling, Wang Xinfang. Chemical constituents of the volatile oil from Radix Linderae microwave distillation GC-MS analysis. Shandong Journal of TCM, 2005,24 ( 6): 70 药理作用: [1] Zheng Minshi .472 Chinese herbal medicines against herpes simplex virus research. Journal of integrated traditional and Western medicine, 1990,10 ( 1): 39 [2] Zhang Tianming, Hu Zhenjiao, Ou Hong, et al. Three kinds of Chinese herbal medicine antiviral various experimental study. Liaoning Journal of TCM, 1994,21 ( 11): 523 [3] Zhang Jie herbal anti herpes simplex virus effect of the progress in the research of traditional Chinese medicine information, 1995, ( 1): 31. [4] The group of Chinese herbal medicine compilation, the compilation of Chinese herbal medicine ( volume one) . Beijing: People's Medical Publishing House, 1975:210. [5] Wang Yusheng. Pharmacology and clinic of Chinese traditional medicine. First edition . Beijing: People's Medical Publishing House, 1983:217. [6]Hao Guixin, Wang Zhengtao, Xu Luoshan, et al. The chemical constituents and pharmacological effects of Radix Linderae Chinese wild plant resources, 1999,18 ( 3): 52. [7] Shi-qian Cheng, Yang Qian of rhubarb with Lindera aggregata. Journal of traditional Chinese medicine, 1992,17 ( 10): 630. [8] Xu Guansun, Zhang group, Liu Qingyun, et al. Fai, Radix Linderae and compound on electrogastrogram. Journal of Anhui University of Traditional Chinese Medicine, 1989,8 ( 03): 74. [9] Zhu Min . The third Chinese Conference of Shanghai, 1996:112. [10] Yao Zhicheng, Fu Xiaohong, to the humanity, such as .100 kind of Chinese herbal medicine on isolated guinea pig trachea histamine research. Chinese herbal medicine, 1985,16 ( 2): 70 [11] Tianjin Nankai hospital. Tianjin medical communications, 1971, ( 8): 1. [12]Ou Changxin, Ding Jia-xin, Zhang Ling .126 experimental study of the effect of traditional Chinese medicine of antithrombin. Chinese herbal medicine, 1987,18 ( 4): 21. [13] Qian Bowen anticancer Chinese herbal medicine clinical utility . Shanghai: Shanghai Translation Publishing House, 1987:68. [14]Yamahara J.Shoyakugaku Zasshi,1983,37(1):84. [15] Li Qinglin, Chou Guixin, Dou Changgui, et al. Radix Linderae extract analgesic, anti-inflammatory action research. Chinese herbal medicine, 1997,20 ( 12): 629 . [16] Wang Chan, Dai Yue, Chou Guixin, etc. Of lindera root total alkaloids on adjuvant arthritis in rats and its mechanism research on pharmacology and clinic of Chinese traditional medicine, 2006,22 ( Z1 ): 63 . 临床试验: [1] Zhao Dezhu rooftop Wuyao powder plus experience in treating 60 cases of chronic prostatitis . Heilongjiang medicine 2004,28 ( 12 ): 960 [2] Zhou Yuhua, Li Chunfang. " Lily lindera root decoction in the treatment of 35 cases of epigastric pain treated with Chinese folk medicine, 2003,11 ( 2): 44. 毒理学: [1] Lai Weiqi, Zhu Ranfeng, Chen Jianguo, et al. Study on toxicity of Lindera aggregata. Occupation and health, 2003, ( 12): 78 |
|