| [English Name] | Loquat Leaf | |
| [Chinese Name] | 枇杷叶 | |
| [Pinying Name] | Pipaye | |
| [Latin Name] | Folium Eriobotryae | |
| [Genera] | Rosaceae | |
| [Efficacy] | zhikepingchuanyao | |
| [Pictures] | Plant picture | Drug picture |
| [Alias] | ||
| [Source] | ||
| [Plant morphology] | ||
| [Distribution] | ||
| [Gathering and processing] | ||
| [Characteristics] | ||
| [Ecology] | It is planted in countryside、plain and sloping land. | |
| [Chemical composition] | ||
| [Pharmacological activities] |
1. Triterpene acid components isolated from the Loquat leaf exhibits anti-inflammation activity[1]. 2. Loquat leaf has preventing cough and expectorant function and the eriobotroside，ursolic aci，and tota1 triterpenic acid isolated from the Loquat leaf are main anti-inflammatory and antitussive components[2-4]． 3. Ursolic acid isolated from the Loquat leaf showed that the protective effect against liver injuries induced by CCl4, D-GaIN, BCG+LPS and AMIT respectively[12]． 4. The extract of Loquat leaf also showed other pharmacological activity such as lowering blood sugar, anti-cancer, anti-virus, antioxidant and so on[5-13]. |
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| [Clinical trial] | 1.Cough:184 cases were treated with Xuanfei Zhike Decoction ( pipaye(Loquat Leaf), gancao(radix glycyrrhizae), xingren(almond), jiegeng(Platycodon Root),etc ) Results showed that 162 cases were cured, 18 cases improved, 4 cases were invalid, the total efficiency was 97.80%[1]. 2. Allergic purpura: 38 cases were treated with pipaye (Loquat Leaf) decoction (fresh pipaye(Loquat Leaf) leaves 50g or dry pipaye(Loquat Leaf) 30), 1 agent daily, 7 days as 1 courses. Results showed that 13 cases were cured, accounting for 34.21%; 19 cases were markedly effective, accounting for 50%; 3 cases were invalid, accounting for 7.89%, the total efficiency was 92.11%[2]. 3.Gout: 28 patients were treated with oral pipaye(Loquat Leaf) mixed wine, 3 ~ 4 times everyday. 1 months as 1 courses. Results showed that after 1 courses of treatment, 13 cases recovered, 14 cases were effective, 1 cases were invalid, the total effective rate was 96.43%[3]. 4.Cough: 54 cases were treated with Zhisou powder ( zhipipaye, jiegeng(Platycodon Root), qianhu (Common Hogfennel Root), fangfeng(radix sileris), etc ), 1 agent daily, Results showed that after 1 months, 19 cases were cured, 17 cases were markedly effective, 12 cases were effective, 6 cases were invalid [4] . 5.Acne vulgaris : pipa Qingfei Decoction (pipaye(Loquat Leaf),sangbaipi(White Mulberry Root-bark), xiakucao（Prunella vulgaris）etc.),combining with vitamin A acid cream; the control group treated with oral viaminate capsule combining with vitamin A acid cream.two groups were 1 times every night, Results showed that the treatment group were better than the control group ( P < 0.05 ) [5]. |
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| [Properties] | ||
| [Medical and other Uses] | ||
| [Dosage] | ||
| [Cautions] | ||
| [Traditional usage] | 1.Facial furuncle 2.Reddish nose 3.Cough with phlegm in throat 4.Cough induced by lung heat 5.Cough induced by wind-heat 6.Cough induced by lung dryness 7.Pertussis 8.hronic bronchitis, cough and asthma with profuse phlegm 9.Vomiting 10.Infantile vomiting milk 11.Febrile disease with polydipsia, drinking profuse water, vomiting at intervals 12.Delactation13.Internal hemorrhoid | |
| [Toxicological studies] | ||
| [Pharmaceutical preparations] | ||
| [References] |
Pharmacological actions: [1] JU Jian-hua, ZHOU Liang, LIN Gen, et al. Studies on constituents of triterpene acids from Eriobotrya japonica and their anti-inflammatory and antitussive effects. Chin Pharm J, 2003,38(10): 752. [2] QIAN Ping-ping, Tian Ju-wen. Preventing cough and expectorant function of loquat leaf on rats. Modern Journal of Integrated Traditional Chinese and Western Medicine, 2004, 13(5) :580. [s] WANG Li-wei, LIU Xin-min, YU Shi-chun, et al. Anti-inflammatory and antitussive effects of Eriobotrya japonica. Chinese Traditional and Herbal Drugs, 2004, 35(2):174． [4]Noreen, Wadood HK, Hidayat, et al. Effect of Eriobotrya japonica on Blood Glucose Levels of Normal and Alloxan-DiabeticRabbits. Planta Med, 1988:196． [5]Tomvnasi N D. Planta Med,1991, 57(5):414． [6] Ito H, Kobayashi E, Li SH, et al. Anti-tumor activity of compounds isolated from leaves of Eriobotrya japonica. J. Agric Food Chem, 2002, 50(8): 2400． [7]Ito H, Kobayashi E, Takamatsu Y, et al. Polyphenols from Eriobotrya japonica and their cytotoxicity against human oral tumor cell lines. Chem Pharm Bull, 2000, 48(5):687． [8] Xia Guo-hao, Zhang Yong-hong, Wang Rui-ping. Survey of anti-tumor activity of ursolic acid. Foreign Medical Sciences (Cancer Section), 2002, 29(6):420. [9] [10] Yan Ling, Chen Hui-min. Immunological activity of Ursolic aci. Hubei institute for nationalities journal, 2005,22(1):51. [11]Kwon HJ, Kang MJ, Kim HJ, et al. Inhibition of NF kappaB by methyl chlorogenate from Eriobotrya japonica. Mol Cells, 2000,10(3):241． [12] XIONG Xiao-juan, CHEN Wu, XIAO Xiao-hua, et al. The Comparative Protective Effect of Ursolic Acid and Oleanolic Acid on Experimental Liver Injury in Mice. JOURNAL OF [13]TIAN Li-ting, MA Long, DU Nian-sheng. Survey of Pharmacology of Aleanolic Acid.
[1] Zhang dingrong. Clinical observation on Cough treated with Xuanfei Zhike Decoction in 184 cases .Yunnan Journal of Traditional Chinese Medicine and Materia Medica，2004，25(2):17． [2] Huang jinding. Allergic purpura treated with pipaye(Loquat Leaf) in 38 cases.China＇s Naturopathy，2005，13(1):49． [3] Deng min. Gout treated with pipaye (Loquat Leaf) in 28cases.Yunnan Journal of Traditional Chinese Medicine and Materia Medica，2006，27(3):78． [4] Liu xing. Cough treated with Zhisou powder in 54 cases.Yunnan Journal of Traditional Chinese Medicine and Materia Medica，2007，28(4):60． [5] Chan jingwen，Chenhua. Acne vulgaris treated with pipa Qingfei Decoction in185 cases.Journal of Fujian University of Traditional Chinese Medicine，2008，18(4):11． |
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