1. Anti-tumor: Curcuma oil preparations can significantly inhibit and damage the growth of ehrlich ascites tumor cells, L615 leukemia of 615 inbred mice, ascites liver cancer cells and other tumor cells in vitro [1]. Intraperitoneal injection of 100% curcuma injection 0.3-0.5mL to mice had a good effect on sarcoma S180 and the inhibition rate of more than 50%. Monomer from the volatile oil of Curcuma, subcutaneous injection of 75mg/kg curcumol and curdione had a higher rejection rate on mice sarcoma S37, cervical cancer U14 and ehrlich ascites carcinoma (FCA). At the electron microscope, nucleus-cytoplasm ratio of the treatment group tumor cell reduced and nuclear shape tend to be normal. Chromatin, nucleoli and chromatin granules reduced, so curcuma can inhibit the murine sarcoma cells metabolic [2]. Curcumol and curdione can markedly damage Ehrlich ascites tumor cells in vitro and to its degeneration and necrosis [3]. Different concentrations of Curcuma oil injection had significant and direct damaging effects on tumor cells, fast and strong. The more tumor cells, the more dose concentration needed to kill 90% of these tumor cells [4]. Anticancer effect of Curcuma both the direct effect and the host immune response [3, 4]. With the clinical intratumoral injection treatment of cervical cancer by curcuma oil, tumor tissue necrosis, local lymphocyte infiltration, in some cases tumor disappeared and cervical smooth, that curcuma can directly kill rumor cells. In the biopsy saw intensive small lymphocytes around the cancer cells, a lot of sinus tissue proliferation in the lymphatic sinuses and blood lymphocytes significantly increased, these prompted valid cases had significant immune response [5]. Experiments showed that the EGA and L615 cell vaccine dealed with curcuma for active immunization, can really make a part of the animals to gain a significant protective effect [6, 7]. Further studies have shown that active immunization with the protective effect of curcuma L615 tumor strains had certain specific, because curcuma L615 tumor immune animals can not produce the effect of cross-protective immunity on the L615 (a new sarcoma leukemia of 615 strains mice). The Curcuma tumor immunohistochemistry animals who had significant inhibition of L615, though can withstand the repeated attacks of the L615 cells at a numnber of 105-3×107, died in L759 tumor cells at a number of 3×105 [8]. This protective immunity effect has a certain stability, once established, can be maintained for a long time (10-13 months), but can not be passed to offspring. Because the vast majority (93/94) of its offspring can not withstand the attacks of 105-3×107 L615 cells, all of them died in typical L615 leukemia and the average survival time had not been seen to extend, that the immune protective effect of parental generation is acquired and can not be passed to offspring [9]. Experiments showed that used a purely female T-739 mice to observe curcuma oil effect on the radiation sensitizing effect of the lung adenocarcinoma (LA-795), curcuma oil by intraperitoneal injection combined irradiation group had a more significant tumor growth delay effect than the alone radiation group, can increase the radiation treatment by 42% to reach moderate sensitizing effect [10]. Curcumol significatly inhibited the growth of MCF7, OV-UL-2, MM231 and HeLa cells and the best concentration of curcumol to inhibit the growth of tumor cells was 50μg/mL. Curcumol can markedly inhibit the RNA synthesis of MCF7, MM231 and HeLa tumor cells but had no impact on the growth of normal breast cells MCF12a and MCF10a. Curcumol can inhibit the proliferation of MCF7, MM231, HeLa and OV-UL-2 cells in vitro and can also inhibit the RNA synthesis of MCF7, MM231 and HeLa cells [11]. β-elemene as terpenes extracted from WenEzhu and can induce a variety of tumor cell apoptosis. K562 cells processed by β-elemene showed the typical manifestations of apoptosis, such as pyknosis, formation of apoptotic bodies, agarose gel electrophoresis DNA ladder, in situ end labeling positive and so on [12, 13]. Apoptotic cell incidence was positively related to the processed concentration and time of elemene, further examined by flow cytometry found the crescendo of the apoptotic peak. At the see time observed that propidium iodide (PI) staining positive necrotic cells were less and did not increase with the improved drug concentration and extended action time. This indicated that the main effect of elemene on human leukemia K562 cells was to induce apoptosis. In addition, curcuma oil injection can inhibit RL-952 in vitro. Light and electron microscopy observation of morphological changes of cancer cells found that the inhibition rate of curcuma oil injection on RL-952 was time-dose dependent. Under light microscope can see cancer cells nuclear condensation and a large number of vacuoles in cytoplasmic. TEM can see obvious swelling of organelles in the cytoplasm, mitochondria dark thickening, cell chromatin fracture and agglutination. This showed that curcuma oil injection in the in vitro effects in human endometrial carcinoma cell line RL-952 may inhibit cancer cell proliferation by non-apoptotic programmed cell death [14]. Application elemene wiht radiation therapy for bone metastases, compared with radiotherapy alone, the efficiency was greatly improved and pain was significantly shortened. Immune Indexes CD3+, CD4+, CD4+/CD8+, IgA, lgM and IgC markedly improved, confirmed the elemene was an effective anticancer drug [15].

2. Anti-early pregnancy: Curcuma rhizomes ethanol extract and its active components (monoterpenes and sesquiterpenes compounds) in rats and mice had very significant effect of anti-early pregnancy, certain anti-implantation effect on the dog. Curcuma oil had the most significant terminating pregnancy, mice intraperitoneal injection and subcutaneous injection of 600-900mg/kg curcuma oil, the effect of anti-implantation and anti-early pregnancy was 70% to 90%, rabbit intraperitoneal injection of 80mg/kg curcuma oil, the anti-implantation effect was 80%. Vaginal injection 400mg/kg, the anti-implantation effect was 100%. Generally 2 to 5 days after pregnancy of administration, embryonic death, absorption or inhibit the implantation of embryos, while 7 to 10 days fater pregnancy of administration was causing a miscarriage or stillbirth. Volatile oil by the subcutaneous, abdominal and vaginal delivery were certain to stop pregnancy but the onset speed was different, intraperitoneal injection was the fastest, vaginal delivery was the slowest and intraperitoneal injection amount was five times less than the amount of vaginal delivery [16]. Fed mice with curcuma decoction also can stop pregnancy [17, 18]. Curcuma oil terminated pregnancy by preventing the embryos implantation to stop growing. Atrophy degradation embryos are free in intrauterine, some embryonic cell died after implantation and in the process of being absorbed [16].

3. Antiviral and antibacterial: Curcuma volatile oil in vitro can inhibit the growth of Golden yellow staphylococcus, the VI hemolytic streptococcus, E. coli, Salmonella typhi, Vibrio cholerae, etc. [19]. Xindeli measured the in vitro inhibition of curcuma oil and erythromycin on the mycoplasma pneumoniae local strain. In vitro experiment showed that the minimum inhibitory concentration (MIC) of curcuma oil on mycoplasma pneumoniae local strain was 2.5μg/mL and the MIC of erythromycin was 0.025μg/mL. Combined curcuma oil with erythromycin, their MIC were 1.25μg/mL and 0.00625μg/mL, that curcuma can inhibit mycoplasma pneumoniae local strain and had better effect when combine with erythromycin [20]. Curcuma oil on influenza virus A3 and adenovirus 7, the median effective concentration (IC50) were 0.0008μg/mL and 0.0004μg/mL, the therapeutic index (TI) were 15 and 30, that curcuma oil had a certain inhibition of influenza virus A3 and adenovirus 7 [21]. Curcuma soft capsule 160, 80 and 40mg/kg by intragastric administration can treat FM1 and RSV induced mouse pneumonia, significantly reduced lung index and reduced mortality. Curcuma oil and glucose injection may have a effect of preventing mumps brain [22]. In addition, GuangxiEzhu oil had a strong antifungal activity and can inhibit the spore germination of plant pathogenic fungi and the growth of mycelium. The MIC curcuma oil 6.25mL/L can significantly inhibit the spore germination of plant pathogenic fungi and the growth of mycelium. Rate of half inhibitory (IC50) showed that GuangxiEzhu had the strongest inhibitive effect on loose red blight bacteria and the weakest effect on fusarium graminearum. Electron microscope observation of hyphae cross-section showed that mycelial cell walls disappeared and protoplasm disintegrated. The results showed that GuangxiEzhu had the potential for the development of biological pesticides [23].

4. Elevated white blood cell: Intraperitoneal injection of 10mL/kg curcuma oil and 10mL/kg 0.3% curcumol for 8 days can significantly confront one time intraperitoneal injection of 150mg/kg cyclophosphamide induced leukopenia and promote leukocyte rebound, that curcuma can increase leukocyte in a certain level [24].

5. Effect on cardiovascular: Curcuma was the best blood circulation drug to increase arterial blood flow,  blood flow peak increase of 252%, after 10 minutes, blood flow increased by 36.0%, vascular resistance decreased by 66.4%. Intravenous infusion of curcuma oil to treat thromboangiitis obliterans patients with blood stasis, with the improvement of clinical symptoms of these patients, limb blood flow significantly improved [1].

6. Hepatoprotective: Curcumol extract and volatile oil can reduce the CCl4 and TAA induced mice ALT improvement, decrease BSP retention and corresponding liver tissue lesions [26]. In addtion, cultivating HSC-T6 cell with different concentration of colchicine, turmeric oil, curcumol, β-elemene and curcumin and found that curcuma oil and curcumol were in HSCT6 cell 24 hours and 12 hours can lower the expression of gene TMPZ, L-6, TGF-p and p450a. From the genetic level, these results reveal the antifibrotic mechanism of curcuma active ingredients curcuma oil and curcumol [27].

7. Effect on acute renal failure: Subcutaneous injection of 50% glycerol saline 1mL/kg to rabbit can cause acute renal failure scorpion, visible dark purple renal swelling increased in the control group. Low magnification intravital microscopy observation can see more dark purple strip vascular stasis. Capillary blood flow stagnation or slow down, intravenous injection of 4mL/kg curcuma injection every day, 3 days later cannot see kidney swelling, dark lightening or had returned to normal and capillary blood flow accelerated. Rabbits after injection of glycerol about 12 hours red sauce urine occurred, urine output was significantly reduced, and some anuria, mental dejected, did not eat, died within 24 to 48 hours. Curcuma group increased urine after 24 hours, though the urine was red sauce, 48 to 72 hours later the urine returned to the pale yellow and no death [28].

8. Inhibition of platelet aggregation and antithrombotic: Gavage of 9.0g/kg curcuma water extract to rat every day, 7 days in total can significantly inhibit the ADP induced platelet aggregation, lower blood viscosity and shorten red blood cell electrophoresis time. Intravenous injection of 1.13g/kg water extraction and alcohol precipitation injection can markedly inhibit thrombosis in rat [29].

9. Analgesic and anti-inflammatory: Fed mice with 200mg/kg WenYujin benzine can significantly inhibit abdominal inflammation caused by acetic acid. Intraperitoneal injection of 200mg/kg WenYujin benzine can markedly inhibit burn local edema. Intraperitoneal injection of 100mg/kg can significantly inhibit croton oil-induced ear inflammation. Intraperitoneal injection of 75mg/kg benzine for 7 days can markedly inhibit subcutaneous granuloma proliferation [30]. In addition, different curcuma pieces had significant inhibition on xylene-induced ear edema and increased capillary permeability induced by acetic acid [31].

10. Effect on digestive system: The study found that 25.0% curcuma water decoction can improve gastric electrical rhythm disorders of functional dyspepsia rat caused by irregular eating and dilute niacin [32]. Isolated rabbit intestinal experiment found that low concentrations of curcuma increased intestinal tension but high concentrations made bowel diastolic [25].

11. Effect on hemorrheology: Different curcuma processed products all had the effect of inhibiting platelet aggregation, anticoagulant and regulating blood rheology [33]. In addition, curcuma injection in the treatment of diabetic retinopathy with good effect [34].

12. Others: Curcuma oil can significantly prolong the incubation period of mice semicarbazide convulsions, indicated that Curcuma oil may affect the brainstem neural function to improve the cortical excitability threshold to fight against epilepsy [35]. Curcuma oil bolt and Yikancuo made of water-soluble compound suppository had a strong effect on fungi and alcohol mother bacteria, and can diminish inflammation, stop pain, promote blood circulation and enhance the immune capacity [36]. Different curcuma oil cream can significantly inhibit the mitosis and proliferating cell nuclear antigen expression of  mouse vaginal epithelial cells of mouse tail scale epidermis rat vaginal epithelial experimental model, promote the formation of the mouse tail scales of the granular layer. This indicated that curcuma oil cream for the topical treatment of psoriasis of moderate efficacy drug and its mechanism may be inhibition of keratin-forming cells proliferation and promote keratinocyte normal differentiation [37].

13. Process in vivo: Intragastric administration of 3H-curcuma can be absorbed quickly and completely, can be measurd in 5 minutes if fed rat, reached the peak in 15 minutes and last about 1 hour, half-life 33 minutes for t1/2a and 12.5 hours for t1/2β. The liver and kidney concentration was 2 to 2.5 times higher than other organizations in vivo distribution, and can pass through the blood-brain barrier, mainly the urinary excretion and bile excretion, there was the phenomenon of enterohepatic circulation [30].

1. Advanced liver cancer:Advanced liver cancer were treated with E’zhu  extract in  8 cases. Results:in 8 cases of liver cancer patients, 2 cases were pump implanted catheter note medicine, 6 cases were intravenous injection drug, 1 cases was stopped drug for allergic reaction, l cases was extravasation, 4 cases were occasionally heating temperature above 38 ℃. 6 patients were lack of power and NaCha symptoms relieve, 4 cases of patients think systemic symptom better, life than the wielder survival time extend 2 ~ 3 months. 3 cases were relief pain in liver area, 2 patients had death with hepatocellular carcinoma (HCC) for the emergence of the late complication and systemic failure. Other did not see special discomfort ^[1].

2. Secondary liver cancer: postoperative colorectal cancer patients were used seldinger technique via femoral artery intubation for liver metastases, chose to enter into hepatic artery, selective arteriography in order to make clear the tumor blood supply arteries, after super chose to enter into the tumor blood supply arteries, for 100% rhizoma zedoariae oil 1 ml, super liquefied iodine oil 10 ml used perfusion embolization, 4 week per time, 2 times as one course  of  treatment, combined with traditional Chinese medicine Ganluxiaodudan add and subtract. Results: 6 cases were to ease, 13 cases were to stable, 9 cases were progress, alleviate rate was 21.5%. No one was in patients with liver/kidney damage and bone marrow suppression complications^[2].

3. Peptic ulcer: E’zhu was mainly drug for  treatment of peptic ulcer in 63 cases, l agent per day, 3 times per agent, 7 days as one course of treatment. the shortest Period of treatment was a course of treatment, the longest was 12 courses. Results: 45 cases were cured,45 case was powerfully , 5 cases were effective, l cases was invalid, the total effective rate was 98.39%^[3] .

4. Herpes simplex venereal toxicity keratitis: E’zhu oil eye drops point eye for treatment of herpes simplex keratitis venereal toxicity in 33 cases, 1 time per 2h, l ~ 2 drops per time, 2 weeks for one course of treatment. Results: 24 cases were cured, 6 cases were  improved, and the total effective rate 90.9%, 33 cases were not adverse reaction^[3] .

5. Toxicity diffuse goiter (Graves) : control group taking propylthiouracil, vitamin B4 oral therapy Graves in 35 cases, treatment for one and a half years. The treatment group was based on the control group treated with E’zhu oil local injections for Graves in 35 patients, one time  per  week, five weeks as  one courses of treatment, then continue to conventional take drugs, treat for 1 year. Results: 26 patients of treatment group were cured, 8 cases were improved and 1 casewas invalid  , heal the recovery rate was 97.2%, and greatly shorten the period of treatment. Control group was cured in 15 cases, improved 8 cases and 12 cases were invalid, the effective rate was 65.8%. the two groups have significant differences (P < 0.05) ^[5].

6. Diarrhea, Control group was used conventional comprehensive treatment in 116 cases of diarrhea, stop drug when diarrhea stop. On the basis of that the treatment group add E’zhu oil glucose injection for treatment of diarrhea in 156 cases, l0mg/kg per day, intravenous drip per day, stop drug when diarrhea stop. Results: two groups defervescence, stop vomit, stop diarrhea, dehydration correct comparison of number of cases, the treatment group cure number than in control group (P < 0.01) ^[6].

7. Mumps: Mumps of 56 patients were treated with E’zhu oil glucose injection (0.04%) as treatment group, 10 mg/kg ,1 time per day, The control group was treated with ribavirin treatment parotitis (26 cases), 10 mg/kg, add 5% glucose 250 ml of intravenous drop, one time per day. Two groups were all for  4 ~ 5 days. Results: treatment group in defervescence and detumescence time was significantly lower than the control group^[7].

8. Chicken pox: E’zhu oil glucose injection on treatment chicken pox in 48 cases, intravenous drop, 10 mg/kg, 1 time per day, when the normal body temperature, boils rash scab, no new rash appear  and stopped drug. Results:To stop drug when (2 times) after the normal body temperature, herpes scab, no new rash appear after taking drug for 2 days in 20 cases (41.7%), to stop drug for 3 days in 18 cases (37.5%), for 4 days in 9 cases (18.8%), l cases for 5days (2%). All cases were cured with the discharge, that did not see the adverse reaction occurred^[8] .

9. Senile vaginitis: E’zhu oil plug for treatment  of senile vaginitis in 78 cases, 1 pieces in vaginal deep per night , 7 days as one course of treatment, to return visit after stopping drug for 3 days. Results: after the treatment all users were feel cool and refreshing and comfortable, the original vaginal dry burning pain and dyspareunia basic disappear. A vaginal flow fluid was significantly reduced or disappeared. 85.6% of the patients said that after use that hot flash, lumbago and urinary irritation and perimenopausal symptoms were different extent improve, there were  9 patients that symptoms had no obvious change. Look from signs and symptoms, 96.6% of patients after treatment feel vaginal mucosa ruddy smooth, significantly reduce congestion, pitting bleeding disappear. And treatment process was not found and the drug related any adverse reaction^[9].

10. Viral myocarditis: Viral myocarditis were treated with the E’zhu oil glucose injection and Huangqi injection in 66 cases, and the control group was 64 cases. Results: the total effectiveness of treatment group was 93.54%, the control group total effectiveness was 73.44%, the two groups have significant differences (P<0.01)^[10].

11. The flu: Control group were treated routinely in 98 cases of flu. The treatment group on the basis that were given E’zhu oil injection, 250 ml (0.1 g) per intravenous drip. If two group patients temperature more than 39 ℃ or when necessary, the temporary to antipyretic and analgesic or physical cooling measures, etc. The two groups were necessary to random anti-infection treatment. Results: in the treatment group 45 cases were markedly improved, 52 cases were effective, 9 cases were failed, the total effective rate was 91.5%, Two groups were statistically significant difference^[11].

12.Foot and mouth disease: The control group were treated with penicillin ,50 ～100u/kg per day, adding intravenous saline infusion for 2 times, that of allergy were intravenous infusion of lincomycin or cephazolin. Ribavirin 10 ～15mg/kg per day. 1 time per day for intravenous infusion. At the same time to the pediatric APC oral or intramuscular injection of Radix Bupleuri, Paine, with physical cooling. On base that the treatment group was combined with E’zhu oil and glucose injection 100～ 250ml, 30～ 40 d/min, 2 times per day for  intravenous infusion. 2 groups of oral mucosa ulcer were for Bingpeng san, other parts were to the calamine lotion applied to the affected area, dehydration were to rehydration. Results: the total time of treatment, the control group was 5.31 ±1.42; treatment group was 4.65 ±1.54 , Two groups were statistically significant difference^[12].

13. Acute upper respiratory tract infection: the treatment group were treated with E’zhu oil and glucose injection ( l0mg/kg per day,for one time intravenous drip ) combined with intravenous drip penicillin, cough medicine for treatment of acute upper respiratory tract infection in 20 cases. The control group was given Virazole injection (10 ～15mg/kg per day) combined with intravenous drip penicillin, cough medicine for treatment of acute upper respiratory tract infection in 29 cases. Results: treatment group in regardless of the defervescence time or symptomatic improvement time was significantly shorter than the Virazole group^[13].

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14.Ⅲ period bedsore: Ⅲ period bedsore was treated with  E’zhu oil daub wound as treatment group and  with  infrared radiation therapy in 44 cases. The control group was used the insulin, gentamicin combined infrared radiation therapy for Ⅲ period bedsore in 44 cases. Results: In the treatment group 32 cases were cured, 9 cases were powerfully, 3 patients were effective, in Control group 20 cases were cured, 16 were powerfully , and 8 cases were effective. Two groups of cure rate and significant efficiency difference have statistical significance (P < 0.0 or P < 0.05) ^[14].

1.       Dermatitis rhus

2.       Deficient spleen-qi, abdominal and foot distension, and vain limbs like the shape of moisture after serious illnesses

3.       Discontinuous and shortness of breath, encopresis and frequent urine

4.       Acid regurgitation

5.       Pain due to injuries

6.       Unbearable and mobile chest pain of womon due to qi and blood disorder

7.       Mobile chest pain of womon due to qi and blood disorder, lumbago

8.       Accumulation of extravasted blood and clot on women, and amenorrhea

9.       Infantile malnutrition with prolonged fever, emaciation with a sorrowful and worn-out look. Eating a lot but do not benitfit to musculature development