1 Protection liver: Guangxi and YunnanPhyllanthus could lower the serum DHBV DNA significantly (P<0.05), butChongqing Phyllanthus couldn’t. And the amount of serum DHBV DNA rose a weekafter stopping of Yunnan Phylianthus. The antiviral effect of GuangxiPhyllanthus combined with ciprofloxacin seems to be strengthened (P<0.05)[1]. Extract of hyllanthus urinaria can only inhibit full length HBV DNA, andmay serve as an essential mechanism in inhibit expression of HBX as well. PUhas a good effect on counteracting the immune live injury in mice by markedlydecreasing the activity of serum transaminase and visceral parameters of liverand spleen, and improving the necrosis of hepatic cells. Phyllanthus urinariaobviously suppressed the contents of ALT, AST, MDA and increase the activity ofSOD enzyme. The numbers of phyllanthus urinaria treatment about ALT, AST andMDA reduced 52.5%, 41.4% and 29.3% and the SOD value raised by 16.3%.Conclusion Phyllanthus urinaria has certain protecting action on hepatic injurecaused by alcohol in mice. the production was decreased markedly 48 hours afterthe treatment of cells with 2~4mg/ml Phyllanthus urinaria, especiallyin combination with 10^-5 mol/L of Ara-A [2-8]. The decrease ofextracellular HBsAg excretion seems to stem from the inhibition ofintracellular HBsAg formation. Phyllanthus urinaria L. had remarkable effectsof inhibition on proliferation as well as toxicities on human hepatoma cells(SMMC 7721) [9]. PUL could induce human hepatocarcinoma cell strain Bel-7402 todifferentiate toward normal style and prevent the occurrence of PHC [10,11].

2 Antibacterialeffects: Pyrrosia had bactericidal and antibacterial effects on staphylococcusaureus and Proteus spp [13].

3 Protectionagainst thrombus formation: The effects of PUW (effective fraction containing60% corilagin from Phyllanthus urinaria ) had significant protection againstthrombus formation in the multiple thrombotic models [14]. PUW in vitro orintravenous injection, markedly suppressed PAI-1 activity while elevated tPAactivity; intravenous PUW also significantly inhibited PAI-1 activ-ity releasedfrom thrombin-activated platelets [15].

4 The others: Thewater extracts of yuntai, yungui, Guangzhou, guangxi phyllanthus plant had aninhibitory effect on HSV-Ⅱto various degrees [16]. The water and alcohol extracts of phyllanthus plant hadthe anti-Lipopolysaccharideeffects [17]. The PU extract can effectively promote the N-cadherin expressionin the testis tissues disrupted by HN₂ [18].

1. Chronic Hepatitis B:

(1) Yexiazhu Fufang capsule are consist of Yexiazhu, Huangqi and Sanqi, etc. 92 cases of patients were divided into three group, which were A, B and C. The group A was treated with Yexiazhu Fufang capsule, the group B was treated with thymosin α₁ and the group C was treated with Yexiazhu Fufang capsule and thymosin α₁ together. Results showed that HBeAg negative conversion ratio of group C was higher than group B (P<0.05，P<0.01) but similar to group A(P>0.05); HBV-DNA negative conversion ratio of group C was higher than both group A and B(P<0.05，P<0.01). The live function recovery rate of group A and C were both increased and had significant effect when compared to group B (P<0.05，P<0.01), while group A and C were no difference (P>0.05) ^[1].

(2) 56 cases of patients were divided into the control group and treatment group at random. The treatment group was treated with interferon-α and Yexiazhu capsule together, the control group was treated with interferon-α. Results: The three and six month ALT recovery rate of treatment group were 89.3% and 96.4%, the control group were 28.6% and 39.3%; the HBeAg negative conversion ratio of treatment group were 57.1% and 67.9%, the control group were 28.6% and 39.3%; the HBV-DNA negative conversion ratio were64.3% and 71.4%, the control group were 35.7% and 42.9%(P<0.05)^[2].

(3)patients were taken the Yexiazhu capsule, results showed that the HBeAg and HBV-DNA negative conversion ratio were 59.0％ and 65.4％, the overall effective rate was 71.0％ ^[3].

2. Hepatitis B of lamivudine resistant: 68 cases of patients were divided into group A (36 cases) and group B (32 cases). The group A was treated with Yexiazhu tablet, the group B was treated with lamivudine. Results: group A: ten cases had significant effect, 15 cases had effect and 11 cases were invalid, the overall effective rate was 69.4%; group B: three cases had significant effect, seven cases had effect and 22 cases were invalid, the overall effective rate was 31.3%. Two group had significant difference (P<0.01) when compared each other^[4].

3. Hepatic fibrosis of hepatitis B: Patients were treated with Yexiazhu decoction(Yexiazhu 30g, Shandougen 12g, Baihuasheshecao 30g, Danshen 30g, Caihu 10g, Yujin 12g, Yanhusuo 15g, Paojiapian 12g, Danggui 15g, Huangqi 15g, Biejia 12g, Shenggancao 9g), three months as one course of treatment, and were treat with two course of treatment continually. Results showed that 16 cases of patients’ HBV-DNA were conversed to negative, the negative conversion ratio was 61.5％ ^[5].

4. Fatty liver: 34 cases of patients were treated with Yexiazhu tablet, results showed that 28 cases had significant effect; the overall effective rate was 82.35% ^[6].

1.       Nyctalopia

2.       Hepatitis

3.       Infantile malnutrition

4.       Acute nephritis

5.       Pyelonephritis

6.       Infantile summer furuncle

7.       Dysentery with pus or blood

8.       Urinary tract infection

[1] Ya-xi Chen, Shu-hua Guo, Ding-feng Zhang et al., Experimental Study on Anti-Duck Hepatitis B Viral Effect of Phyllanthus erinaria of Different Areas and Combined Therapy with Other Drugs, Chinese Journal of Integrated Traditional and Western Medicine, 1995, 15 (4): 225.

[2] Sino-Japan Friendship Institute of Clinical Pharmacy and Pharmacology room. Related to anti-hepatitis B virus drugs investigation. Journal of Sino-Japanese Friendship Hospital, 1991, 5 (4): 242.

[3] Li-sheng Peng, Jin-song He, Guang-dong Tong et al., Inhibition of extract of phyllanthus urinaria L1on hepatitis B virus and hepatitis B X gene in vitro, Chinese Journal of Integrated Traditional and Western Medicine, 2006, 16 (6): 340.

[4] Tian-bao Feng, Guang-jun Tian, Hua Li et al., An Exper imental Study of Phyllanthus urinaria for Counter acting Immune Liver Injury in Mice, Traditional Chinese Drug Research and Clinical Pharmacology, 2005, 16 (5): 343.

[5] Shu-hua Cai, Ru-hua Jiang, Protective ef fect of phyllanthus urinaria on alcoholOinduced liver injury in mice, J Clin Hepatol, 2007, 10 (01): 19.

[6] Shi-wen Zhou, Chuan-fu Xu, Ning Zhou et al., Phyllanthus protective effect on experimental liver injury in mice, Journal of Chinese Medicinal Materials, 1994, 17 (12): 31.

[7] Xiao-hong Chen, You-mei Hu, Ya-qin Liao, In chongqing, pearl on the rat liver cells CCl4 damage of protection, Pharmacology and Clinics of Chinese Materia Medica, 1994, 10 (4): 17.

[8] Xu-huai Ji, Yi-zhong Qin, Wei-ye Wang et al. Effect of Extracts from Phyllanthus Urinaria L. on HBsAg Production in PLC/PRF/5 Cell Line, China Journal of Chinese Materia Medica 1993, 18 (8): 496.

[9] Cang-jun Wang, Dei-pei Yuan, Wei Chen et al., Effects of Phyllanthus Urinaria L. on Human Hepatoma Cells, Lishhizhen Medicine and Materia Medica Research, 1997, 8 (6): 499.

[10] Yu-hua Huang, JIan-jun Zhang, Xue-sheng An et al., Phyllanthus compound to induce differentiation of human hepatoma cell line Bel-7402, Journal of Hubei university of Traditional Chinese Medicine, 2000, 2 (1): 10.

[11] Jian-jun Zhang, Yu-hua Huang, Xue-sheng An et al., Experimental Study of Phyllanthus drug serum to induce differentiation of human hepatoma cell line, Chinese Journal of Traditional Medical Science and Technology, 2002, 9 (5): 289.

[12] Guangxi College of Medicine of the National Selection of Chinese herbal medicine information, 1972: 280.

[13] National Herbal Compendium writing group. National Herbal Compendium (Volume I). 1st edition, Beijing: People's Health Publishing House, 1976: 263.

[14] Zhi-qiang Shen, Zhi-jun Dong, Lan-o Wu et al., Effects of the Fraction from Phyllanthus Urinaria on Therombosis and its Mechianism, Natural Product Research and Development, 2003, 15 (01): 46.

[15] Zhi-qiang Shen, Feng Chen, Jian-qun Shen et al., Effects of the fraction from Phyllianthus Urinaria on Thrombolysis and the Caticity of PAI-1 and TPA, Natural Product Research and Development, 2003, (05): 441.

[16] Wei-zhen Guo, Xiao-long Deng, Bo-zhen Dong et al., Effect of Compound Lingzhi Jiangtang Capsule on Morphology of Islet B Cell in Rats, Journal of Guangzhou University of Traditional Chinese Medicine, 2000, 17 (1): 54.