1. The Piperine and its derivatives (Antiepilepsirine, 7302, 7306, 7446,  7448) belong to a new class of anticonvulsants. They were found to be able to protect rats and mice from seizures produced by maximal electroshock, metrazol, picrotoxin, strychnine, tubocurarine and sodium glutamate, and reduce the mortality of animals to various extends. In addition, they were found to have sedative effects and intensify the central action of other depressants^[1-3]. The mechanism of anticonvulsive action may be related to increase the concentration of 5-HT and decrease glutamate, aspartate and block the KAR in the mouse brain^[4].

2. Piperine may prevent the formation of cholesterol gallstone through inhibiting the lithogenic role of aminopeptidase N^[5].

3. Piperine has the ability to prevent delayed cerebral vasospasm after subarachnoid hemorrhage

in rabbit, which maybe has some relations with the effect of Piperine to protect the activity of eNOS and reduce production of ET-1, TNF-a, IL-1β and IL-6^[6,7].

4. Piperine also exhibits anti-inflammatory action and cytotoxicity effect on cultured human HepG2 cells in vitro, it could inhibit proliferation and induce apoptosis of HepG2 cells^[8,9].

1. infants diarrhea:①55 cases of patients were treated with hujiao(Pepper) powder (pepper 40g , rougui (Cinnamon) 10g ,dingxiang(clove) 10g, Wu Zhuyu(Medicinal Evodia Fruit) 10g,sharen(Villous Amomum Fruit) 10g , matixiang(Saruma henryi )10g. grinded Altogether) ,it coverd on the umbilicus, 5～10min every time, 1 times daily, the treatement time last 1day to 4days. the average time was 3 days. Results showed that 41 cases were cured, 10 cases improved, 4 cases were invalid, the total efficiency was 92.73%^[1].  ②white pepper l0 grain grinded with yellow wine or white win,covered on Shenque acupoint, Results showed that 42 cases had effect(72.4%), 16 cases had significant effect ( 27.5%)^[2]。

2.cough: 166 cases were treated with pepper mixed with cool oil and made ointment to spread in about 3cm×5 cm sizes Zhuifeng plaster, covered on bilateral Feishu acupoint. 5 days for 1 coures of treatment. Results showed after 1～3 courses of treatment, 121 cases were cured, accounting for 72.89%; 36 cases improved, accounting for 21.69%; 9 cases were invalid, accounting for 5.42%. The total efficiency was 94.58% ^[3].

1.Tang Bencao: descending qi, warning the middle jiao, removing phlegm, reducing wind-cold in organs

2.Haiyao Bencao: removing stomach coldness caused by qi deficiency, indigestion, cholera with qi regurgitation leading to sudden pain in chest and abdomen, harmonizing qi

3.Rihuazi Bencao: regulating five zang-organs, relieving pain and coldness in chest and abdomen due to cholera, strengthening kidney qi, dealing with cold dysentery, removing toxin from fish, flesh, terrapin and herbs

4.Bencao Mengquan: postpartum stabbing pain, swelling and pain caused by trauma

5.Bencao Gangmu: warning stomach and intestines, removing regurgitation due to accumulated damp-cold, reduced distention and indigestion due to yin deficiency, yin toxin, toothache due to deficiency fire.