1．Anti Tapeworms: A protease in Omphalia can kill beef/pork/ dog tapeworms though destroy tapeworms scolex, polypide cortical and tissues[1-6].

2．Anti infusorian: Omphalia can kill infusorian stage at intestinal tract through make it granulation[7,8].

3．Effect on lumbricus and hookworms: 50% ethanol extract can inhibit Ascaris suum in vitro and Omphalia powder show cure effect on ancylostomiasis in vivo[9,10].

4．Immune Enhancement: Omphalia polysaccharides has obviously anti-inflammatory in differen animal model through promote release of adrenal cortex hormone or prohibit it metabolism.In addition, it can improve mice phagocytize function in reticuloendothelial system and humoral immune function[11].

5．Anticancer: Protease can inhibit mice fleshy tumor and inhibition ratio from 33.3% to 69.3%[12]. Omphalia extract show inhibit effect on HepG2 cell in vitro and U14 ascites carcinoma in mice[13,14].

Leiwan (stone-like omphalia)

1. Infantile ascariasis:Leiwan (Omphalia) enteric capsule, 0.5g pergrain. The diagnosed ascariasis children(83) were given 0.5g leiwan, 3 times aday, continuation take 3 days, recheck 7 days later, 67 cases were cured, 12cases were excellent, 4 cases were invalid. The cure rate was 80.7%, theeffective rate was 95%. 56 cases were ejectmented ascaridesafter take the medicine 2 days later ^[1].

2. Alopecia areata: grind the leiwan(Omphalia)into minuteness powder, cut the shengjiang(ginger) a flat piece, inunctionaffected part, cut the surface again, touch the leiwan(omphalia) powder withthe rest of the ginger and inunction the affected part for a moment, 2-3times aday, construe for 7-12 days and withdrawal, new hair grow slowly at localitypart. Treat 100 cases, the longest time was 12 days,anda total of 166 cases, the shortest time was 7 days, a total of 34cases. The cure rate was 98% ^[2].

1.Ascariasis, oxyuriasis

2.Taeniasis

3.Pain in chest and abdomen caused by parasitic disease

4.Infantile fever without sweating

5.Infantile convulsion, aversion to chills and fever

Pharmacologic Actions:

[1] Barnyard Tian Kentaro. Dosanjh Tokyo Medical,1938,(3079):19．

[2]Institute of Materia Medica,Chinese Academy of Medical Sciences. The Chinese Materia Medica vol 3. People’s Medical Publishing House, 1960:605．

[3] Wu Zhenxi. Shanghai Journal of Traditional Chinese Medicine, 1983,(2):33．

[4] Liu Guosheng. Journal of Traditional Chinese Medicine, 1955,(3):28．

[5]Zhao Guanhong. Chinese Journal of Parasitology and Parasitic Diseases, 1998,16(2):113．

[6] Chen Xinyu. Journal of Modern Clinical Medical Bioengineering, 1999,5(3):199．

[7] Wang Yingru. Chinese Traditional Patent Medicine, 1981,(9):43．

[8]Henan Medical College pharmacology Department. Journal of Zhengzhou University (Medical Sciences), 1960,(7):23．

[9]Wu Ruiyun. National Medical Journal of China, 1948,34(10):347．

[10]Li Renzhong. Shanghai Journal of Traditional Chinese Medicine, 1957,(5):22．

[11]Wang Wenjie. Acta Pharmaceutica Sinica, 1989,24(2):151．

[12]Yao Yonghua. Journal of Ningxia Medical College, 1979,(1):50．

[13]Chen Yitao. Progress in Modern Biomedicine, 2008,8(7):1250．

[14]Yan Mingyu. Journal of Wenzhou Medical College, 1993,1:10．
clinical experiment

[1] Shen Yun-hua, Wang Xu, LiKe-lei. The applications of leiwan (Omphalia) Enteric Capsules in Treatment ofInfantile ascariasis. Anthology of Medicine, 2001, 20(2):205.

[2] Han Gui-lan, Lv Shan-yun.The treatment of Alopecia Areata with Leiwan (Omphalia) and shengjiang (Ginger).Chinese Journal of Synthetical Medicine. 2001, 2(3):262.